Effects of Cigarette Smoke on Respiratory Function

Carson, Sara; Goldhamer, Richard E.; Mackars, A; Je, Silson

doi:10.1080/00039896.1965.10664272

Cited by 9 publications

(3 citation statements)

References 1 publication

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“…Our results suggest that the response to tobacco smoke is more generalized, due as much to the vapour as to the particulate phase. This conforms with the findings of Carson, Goldhamer, Mackars, and Silson (1965), who found that the increase of airways resistance in guinea-pigs exposed to cigarette smoke could be reduced by either carbon or cellulose acetate filters. Our findings of a reduction of response to smoking from a simple cellulose acetate filter have been confirmed by Robertson, Warrell, Newton-Howes, and Fletcher (1969), who also showed that a filter with higher retention efficiency reduced the response more than one with a lower efficiency.…”

Section: Discussionsupporting

confidence: 92%

Changes in airways conductance on smoking a cigarette: A study of repeatability and of the effect of particulate and vapour phase filters

Clarke¹,

Guyatt²,

Alpers³

et al. 1970

Thorax

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Measurements of airways conductance using a body plethysmograph were made on 25 men before and after smoking one cigarette on each of four days and before and after a control period without smoking on another day. The repeatability of these measurements and of the bronchoconstrictor effect of smoking was studied. The variance was as great as that observed in a previous field study in industry despite close supervision and a stable environment before the measurements. We think this variation is due to random fluctuation rather than to the lack of close supervision inevitable in a field survey.A second study was made on 16 of the men in which the bronchoconstrictor effect of plain and filtered cigarettes was compared. Filters which removed either the particulate or the vapour phase of the smoke had a similar effect in reducing the bronchoconstrictor response of cigarette smoking.Guyatt, Berry, Alpers, Bramley, and Fletcher (1970) reported a field study in which measurements of airways conductance were made with the body plethysmograph on a large number of working men before and after smoking a cigarette. They related these changes to smoking habits and symptoms of bronchitis. They found considerable variation in repeat measurements and suggested that this might have been due to the men having been studied during the course of their day's work which precluded careful control of their activities and environment immediately before the measurements were made. It (McKerrow, McDermott, and Gilson, 1960) according to the technique described by Freedman and Prowse (1966).Airways conductance (Gaw) and thoracic gas volume (Vtg) were measured by the method of DuBois. Botelho, and Comroe (1956) using a body plethysmograph housed in a caravan trailer (Guyatt.

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Section: Discussionsupporting

confidence: 92%

Changes in airways conductance on smoking a cigarette: A study of repeatability and of the effect of particulate and vapour phase filters

Clarke¹,

Guyatt²,

Alpers³

et al. 1970

Thorax

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“…This bronchoconstrictive effect can be abolished by pretreatment with atropine or Isuprel®, and is potentiated by the administration of (J-adrenergic blocking agents (1,3,4). The relative contribution of nicotine, particulate matter, or the gaseous phase of cigarette smoke to bronchoconstriction is unknown (1,(5)(6)(7)(8). Filters reduce the amount of tar and particulate matter in cigarette smoke, but the nicotine content is less affected.…”

Section: The Immediate Effect On Lung Function Of Smoking Filtered Anmentioning

confidence: 99%

“…Various studies have shown that apnea during sleep occurs as a prominent feature in syndromes of dynamic upper airway obstruction (1-3), obesity-hypoventilation (4,5), and central hypoventilation (6)(7)(8), and it has been reported to contribute in some instances to sudden in- fant death syndrome (9). Apnea has been defined as cessation of air flow for periods exceeding 10 s (1).…”

Section: Use Of Laryngeal Sound Recordings To Monitor Apnea1mentioning

confidence: 99%

The Immediate Effect on Lung Function of Smoking Filtered and Nonfiltered Cigarettes¹

Silva¹,

Hamosh²

1980

Am Rev Respir Dis

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We measured and compared the effect of smoking a filtered and a nonfiltered cigarette on instantaneous maximal expiratory flow rates (Vmax50 and Vmax25) and airway resistance (Raw). We found a significant increase in Raw after both cigarettes, and a small decrease in Vmax50 after smoking the nonfiltered cigarette. The change in Vmax50 after smoking the filtered cigarette was not significant. We suggest, on the basis of these data, that filtered cigarette smoke reduces some of the constituents that cause bronchoconstriction in the large and central airways.

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Carcinogenic activity of smoke condensate from cigarettes with ammonium sulfamate-treated paper

Bock

Bross

et al. 1974

Cancer

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The carcinogenic activities of smoke condensates from experimental cigarettes, the paper of which had been treated with ammonium sulfamate (AS), were compared on mouse skin with the activities of condensates from untreated control cigarettes in two tests. During most of the test periods, the tars from the experimental cigarettes produced significantly fewer tumors than those from the controls; toward the end, these differences decreased, and the differences in final tumor incidence were not statistically significant. The time course of tumor development, however, did differ significantly (p < 0.05), and implied a reduction in cocarcinogen concentration.

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Effects of Cigarette Smoke on Respiratory Function

Cited by 9 publications

References 1 publication

Changes in airways conductance on smoking a cigarette: A study of repeatability and of the effect of particulate and vapour phase filters

Changes in airways conductance on smoking a cigarette: A study of repeatability and of the effect of particulate and vapour phase filters

The Immediate Effect on Lung Function of Smoking Filtered and Nonfiltered Cigarettes¹

Carcinogenic activity of smoke condensate from cigarettes with ammonium sulfamate-treated paper

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Effects of Cigarette Smoke on Respiratory Function

Cited by 9 publications

References 1 publication

Changes in airways conductance on smoking a cigarette: A study of repeatability and of the effect of particulate and vapour phase filters

Changes in airways conductance on smoking a cigarette: A study of repeatability and of the effect of particulate and vapour phase filters

The Immediate Effect on Lung Function of Smoking Filtered and Nonfiltered Cigarettes1

Carcinogenic activity of smoke condensate from cigarettes with ammonium sulfamate-treated paper

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The Immediate Effect on Lung Function of Smoking Filtered and Nonfiltered Cigarettes¹