Effects of chronic beta-adrenoceptor blockade on variability in blood pressure and heart rate

Girard, Arlette; Laude, Dominique; Japundžić, Nina; Elghozi, Jean‐Luc

doi:10.1097/00004872-199112006-00159

Cited by 5 publications

(4 citation statements)

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“…Moreover, because TPRI and DBP, which can be considered as indices of arteriolar tone, were similarly increased after ivabradine and propranolol, the reduced increase in SBP with propranolol resulted from the lower value of CI and stroke volume and thus probably also from the negative inotropic effect of this drug. Simultaneously, the lower value of low-to high-frequency ratio observed after ivabradine and propranolol reflects the inhibitory effect of these treatments on the sinus node during this test [23,24,31]. However, in absence of direct measurement of cardiac preload, a lower venous return after β-blockade than I f current inhibition could participate in the observed decrease in cardiac output.…”

Section: Discussionmentioning

confidence: 89%

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Comparative effects of ivabradine, a selective heart rate‐lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise

Joannidès

Moore

Iacob

et al. 2005

Brit J Clinical Pharma

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AimTo compare in humans the effects of ivabradine and propranolol on cardiac and systemic haemodynamics at rest, during tilt and exercise. MethodsNine healthy volunteers randomly received single oral doses of ivabradine (Iva, 30 mg), propranolol (Propra, 40 mg) or placebo (Plac) during a double-blind crossover study. Doses were selected to be equipotent in heart rate (HR) reduction. HR, systolic and diastolic blood pressure (SBP, DBP), cardiac index (CI, bioimpedance), rate pressure product (RPP), plasma epinephrine (E) and norepinephrine (NE), were measured at rest at baseline, before and after two tilt and exercise tests, star ted 2 and 5 h after drug intake. Heart rate variability (low to high frequency ratio LF/HF) was evaluated at rest and at 5th minute of tilt. ResultsAt rest, HR and RPP decreased similarly with Iva and Propra (both P < 0.01). During tilt, HR increased less with Iva than Propra ( P < 0.01), LF/HF decreased after Iva ( P < 0.03), SBP and mean blood pressure decreased after Propra (both P < 0.01), RPP decreased similarly after Iva and Propra (both P < 0.01) and CI decreased to a greater exent with Propra than with Iva or Plac (both P < 0.04). During exercise, Iva and Propra similarly decreased HR (both P < 0.01) and RPP ( P < 0.01). ConclusionsThese results demonstrate that for a similar decrease in H R at rest and during sympathetic stimulation, acute administration of ivabradine, a selective hear t ratelowering agent, decreased myocardial oxygen demand to the same extent as a reference β -blocker, propranolol, but without evidence of depressant effect on cardiac function.

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Section: Discussionmentioning

confidence: 89%

“…After ivabradine and propranolol resting HR decreased similarly compared with placebo [treatment effect: P < 0.002; Iva vs. Plac P < 0.01, Propra vs. Plac P < 0.01, Iva vs. Propra P < 0. 31…”

Section: At Rest (Table 1)mentioning

confidence: 99%

Comparative effects of ivabradine, a selective heart rate‐lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise

Joannidès

Moore

Iacob

et al. 2005

Brit J Clinical Pharma

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“…In addition the modulus of this respiratory HR oscillation (RSA) was least when the subject was breathing at a high frequency (HF) of 18 cycles/min, reflecting the reduced amplitude of this oscillation. In the supine position the low frequency (LF) (100 mHz, Mayer waves) HR oscillation was relatively small when compared to the marked LF observed in standing position (Girard et al 1991).…”

Section: Introductionmentioning

confidence: 87%

Effects of Respiration on Blood Pressure and Heart Rate Variability in Humans

Elghozi

Laude

Girard

1991

Clin Exp Pharma Physio

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1. Non-invasive continuous finger blood pressure (BP) measurement and a spectral technique based on the Fourier transform (FT) were recently combined to quantify short-term fluctuations in haemodynamic variables. 2. Systolic BP (SBP) recording combined low frequency (LF, Mayer waves) plus high frequency (HF, respiratory) oscillations. The presence of HF oscillations of SBP probably reflects fluctuations in cardiac output. Heart rate (HR) also exhibited a combination of low and HF (respiratory) oscillations. The vagus nerve mediates the efferent control of the respiratory sinus arrhythmia (RSA). 3. During controlled breathing in a supine position, a change in SBP is associated with an opposite consequent change in HR. Respiratory sinus arrhythmia could therefore depend on the baroreceptor-HR response to underlying SBP oscillations. 4. The fast regulation of R-R interval by SBP through the baroreceptor-HR reflex may explain why the respiratory variations in the diastolic BP are small.

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“…Blood pressure and heart rate recordings Finger arterial pressure was measured continuously by using a non-invasive plethysmographic recording device (Finapres® model 2300, Ohmeda, Maurepas, France) [9]. The cuff was fitted to the third finger of the dominant hand and placed at heart level.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of non‐invasive measurement and of short‐term variability of blood pressure and heart rate in healthy volunteers.

Dimier-David

Billon

Costagliola

et al. 1994

Brit J Clinical Pharma

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1 Spectral analyses of blood pressure and heart rate oscillations are increasingly used to assess the influences of diseases and drugs on the autonomic nervous system. Such influences can only be interpreted in view of the spontaneous variability of these oscillations. We therefore studied the reproducibility of power spectral analyses of blood pressure and heart rate fluctuations measured by a non-invasive finger plethysmographic method in 24 healthy volunteers. 2 Intra-observer reproducibility was assessed from measurements obtained on 3 consecutive days and 1 month later in each subject. Inter-observer reproducibility was assessed by comparing measurements made by two observers on one occasion. 3 There was no significant difference in standard haemodynamic and spectral analysis parameters (low frequency: 60-130 mHz and high frequency: respiration rate ± 30 mHz) measured on 3 consecutive days and 1 month later in each subject. The standard deviation of differences between systolic blood pressure or heart rate oscillations on different occasions was in the 150-200 and 50-100 mm Hg Hz-1/2 or beats min-' Hz-"/2 range for low frequency and high frequency oscillations respectively. Similar results were found when inter-observer reproducibility was considered. 4 From these results, we derived a sample-size table giving the number of subjects to be included in studies of cross-over or parallel design in order to detect a nonrandom difference in spectral analysis parameters. For example, detection of a 200 mm Hg Hz-1/2 difference in low frequency oscillations of systolic blood pressure at an alpha and a beta risk of 0.05 and 0.10 respectively would require the inclusion of approximately 15 subjects in a cross-over design study and 50 subjects in a parallel design study. 5 We conclude that, under our experimental conditions, non-invasive measurements of blood pressure and heart rate oscillations are reproducible. This technique can be used to assess the influences of diseases and drugs on the autonomic nervous system using a reasonably small number of subjects.

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Effects of chronic beta-adrenoceptor blockade on variability in blood pressure and heart rate

Cited by 5 publications

References 0 publications

Comparative effects of ivabradine, a selective heart rate‐lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise

Comparative effects of ivabradine, a selective heart rate‐lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise

Effects of Respiration on Blood Pressure and Heart Rate Variability in Humans

Reproducibility of non‐invasive measurement and of short‐term variability of blood pressure and heart rate in healthy volunteers.

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