Effects of chronic amphetamine treatment on the glutamate concentration in cerebrospinal fluid and brain: Implications for a theory of schizophrenia

Differential effects of endomorphin-1 and -2 on amphetamine sensitization: Neurochemical and behavioral aspects

“…On the other hand, glutamate concentrations increased significantly in all the tested brain areas in both the amphetamine-and endomorphin-treated rats. These results agree with a previous report by Kim et al (1981) that chronic amphetamine treatment increased tissue levels of glutamate in the striatum and frontal cortex. The changes of glutamate concentration could possibly be related to a previously described D 1 receptor supersensitivity after chronic amphetamine or cocaine treatment (Henry and White, 1991).…”

Homers regulate drug-induced neuroplasticity: Implications for addiction

“…Whereas repeated cocaine administration produces robust drug-induced glutamate sensitization within the NAC [e.g., 31,35,47,57], repeated dosing with non-toxic regimens of amphetamine or methamphetamine elicits little effect upon the capacity of these drugs to alter glutamate levels within the corticoaccumbens pathway [61,272]. In contrast, repeated high dose amphetamine or methamphetamine regimens that induce dopamine neurotoxicity produce an increase in glutamate content within the PFC [273], a delayed increase in dorsal and ventral striatal glutamate levels [60,[274][275][276][277] and enhance potassium-stimulated, but not methamphetaminestimulated, glutamate release within the PFC [277]. Whether or not the more modest effects of amphetamine regimens upon corticoaccumbens glutamate relate to the duration of withdrawal remains to be determined.…”

Axo-Axonic Synapses in the Rat Striatum

“…Several biochemical and pharmacological findings indicate the existence of inhibitory dopamine receptors localized on cerebral cortical afTerents to the rat striatum [4,9,11,13,14,[17][18][19], The cortico-striatal fibers are glutamatcrgic. The question of whether do paminergic inhibitory synapses exist on the glutamatergic terminals in the striatum is of interest for the theory of schizophrenia [10].…”