volume 93, issue 0, P2-O-062 2020
DOI: 10.1254/jpssuppl.93.0_2-o-062
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Abstract: Chemerin is an adipocytokine which binds to several receptors such as chemokine-like receptor 1 (CMKLR1) and chemokine (CC motif) receptor-like 2 (CCRL2). Chemerin-9, an active fragment of chemerin, induces vasoconstriction via CMKLR1. Pulmonary artery hypertension (PAH) is a fatal disease caused by the increased PA resistance. We examined the effects of chemerin-9 on contractility of PA from monocrotaline (MCT)-induced PAH rat. Isometric contraction of isolated PA from MCT-injected (MCT) rat was measured. Pro…

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