Effects of chelating agents on testicular toxicity in mice caused by acute exposure to nickel

Xie, Jimin; Funakoshi, Takayuki; Shimada, Hideaki; Kojima, Shoji

doi:10.1016/0300-483x(95)03134-2

Cited by 41 publications

(26 citation statements)

References 23 publications

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“…Xie et al [27] evaluated the protective effects of chelating agents against the testicular toxicity in ICR mice induced by acute exposure to NiCl 2 . Mice were injected intraperitoneally with 0.5, 1.0, 3.0, or 5.0 mg Ni/kg bw and sacrificed 24 h after injection.…”

Section: Testicular Effectsmentioning

confidence: 99%

Reproductive toxicology of nickel – Review

Forgács¹,

Massányi

Lukáč

et al. 2012

Journal of Environmental Science and Health, Part A

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The goal of this minireview is to summarize our current knowledge on the reproductive toxicity of soluble nickel salts. We made an attempt to present the most relevant data obtained from in vivo and in vitro experiments performed on mammals, mammalian primary cell cultures and cell lines. Nickel has been demonstrated to disturb the mammalian reproductive functions at several levels of regulation. The results of previous investigations indicate that the hormonal effects may play an important role in the reproductive toxicology of nickel both at the neuroendocrine and gonadal levels in the hypothalamic-pituitary-gonadal (HPG) axis. At the molecular level, it may be important that nickel may substitute certain other metals in metal dependent enzymes, leading to an altered protein function. It readily crosses the cell membrane via calcium channels and competes with calcium for specific receptors. Nickel can cross-link aminoacids to DNA, lead to formation of reactive oxygen species (ROS), moreover mimic hypoxia. These changes may lead to the activation of some signaling pathways, subsequent transcription factors and eventually to alterations in gene expression and cellular metabolism. These events are likely to be involved in the reproductive toxicity of nickel.

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Section: Testicular Effectsmentioning

confidence: 99%

Reproductive toxicology of nickel – Review

Forgács¹,

Massányi

Lukáč

et al. 2012

Journal of Environmental Science and Health, Part A

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“…Previous studies on laboratory mice and rats demonstrated accumulation of nickel in several organs following administration of nickel by various routes (Whanger 1973, Clary 1975, Medinsky et al 1987, Dwivedi and Misra 1990, Pereira et al 1995, Xie et al 1995, Tallkvist and Tjalve 1997. These laboratory studies are not directly applicable to animals in serpentine areas because mode of administration, dose, chemical form, and other dietary components affect the absorption and accumulation of nickel.…”

Section: Resultsmentioning

confidence: 99%

“…In laboratory studies, nickel has caused cancer (Kasprzak et al 1986, Lin andCosta 1994) and impaired function of several organs (Foulkes and Blanck 1984, Dieter et al 1988, Li and Wang 1989, Ilback et al 1994, Iscan et al 1995, Xie et al 1995, 1996, Obone et al 1999. Although my results show that nickel does not accumulate in most organs or tissues tested, this does not rule out negative effects of nickel on those organs and tissues.…”

Section: Resultsmentioning

confidence: 99%

“…Nickel accumulated in the spleen, liver, and kidney of mice after injections of metallic nickel (Pereira et al 1995(Pereira et al , 1998. Injection of nickel chloride lead to accumulation of nickel in the liver and kidney (Xie et al 1995) or in the kidney, lung, liver, heart, and spleen (Dwivedi and Misra 1990). Respiratory exposure to nickel led to accumulation in liver, kidney, spleen and other organs, as well as the lung (Clary 1975, Medinsky et al 1987, Benson et al 1988.…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal and tissue levels of nickel in deer micePeromyscus maniculatus and woodratsNeotoma fuscipes from serpentine and nonserpentine areas

Oswald

2004

Acta Theriol

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Ch. 2004. Gastrointestinal and tissue levels of nickel in deer mice Peromyscus maniculatus and woodrats Neotoma fuscipes from serpentine and nonserpentine areas. Acta Theriologica 49: 419-426.Serpentine geologic formations have soils high in nickel. Nickel exerts deleterious effects on several body systems, and often accumulates in organs of laboratory animals exposed to nickel. To establish if deer mice Peromyscus maniculatus Wagner, 1845 and dusky-footed woodrats Neotoma fuscipes Baird, 1858 of serpentine areas ingest nickel, and to determine if nickel accumulates in body tissues, I measured nickel in several organs and tissues of animals from serpentine and nonserpentine sites in southern Oregon. Nickel was present in significantly greater concentrations in the contents of the stomachs and small intestines of P. maniculatus and N. fuscipes from serpentine areas than in those of animals from nonserpentine areas. Nickel was not detected, or was present in only trace amounts, in the livers, kidneys, spleens, hearts, lungs, brains, skeletal muscles, and bones of both species from both serpentine and nonserpentine sites. P. maniculatus from serpentine areas had significantly greater concentrations of nickel in the seminal vesicles, testes, and uteri and ovaries than did P. maniculatus from nonserpentine areas.

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“…Il sembl e par ailleurs que la pathologie de l'appareil reproducteur mâle se multiplie [3,4]. D'une manière concomitante , de nombreuses études expérimentales ont suggéré l'effe t nocif , sur la fonction sexuelle, de nombreux facteurs toxiques présents dans notre environnement, on peut citer notamment le cadmium [5], le nickel [6], le vanad ium [7], le manganè se [8], le plomb [9], le tabac [10], les pesticides [4], etc.…”

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Impact de l'exposition chronique aux gaz d'échappement d'origine automobile sur certains biomarqueurs touchant la fonction hormonale sexuelle mâle, la fonction rénale et l'hémogramme chez le rat

Smaoui¹,

Ghorbel²,

Boujelbene³

et al. 2000

Pollution Atmosphérique

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RésuméLes gaz d'éc happement des véhicules automobiles constituent une importante source de pollution urbaine. L'objectif de . cette étude est de mettre en évidence, chez le rat, les effets en fonction du temps, d'expositions répétitives aux gaz d'échap-pement d'un moteur à essence, sur la variation de certains biomarqueurs touchant la fonction hormonale sexuelle mâle, la fonction rénale et l'hémogramme. Les résultats montrent une baisse du taux de la testostérone sérique chez les rats exposés aux gaz d'échappement. Cette baisse est à l'origine d'une stérilité masculine déjà démontrée dans notre laboratoire au cours d'un travail antérieur (histologie testiculaire et expériences d'accouplement). Cette stérilité est réversible parce que les rats pollués retrouvent leur activité sexuelle normale deux mois après arrêt du traitement polluant. Une augmentation du taux de monoxyde de carbone sa nguin, ave c acc umulatio n du plomb au nivea u du sang et de la queue est signalée chez ces rats. Les analyses biochimique s montrent que la glycémie, la créatinémie et l'urée sanguine augmentent chez les rats traités. La créatininurie baisse. Ceci témoigne d'une atteinte rénale. Elles montrent de même chez les rats traités, par comparaison aux témoins, une augmentation du nombre des globules rouges, de l'hématocrite, du taux sanguin d'hémoglobine et du VGM, et une baisse de la CGMH. Le monoxyde de carbone et le plomb détectés dans le sang de ces animaux sont à l'origine de ces perturbations hématologiques.En conclusion, nos résultats montrent que les gaz d'échappement d'automobile à essence induisent chez le rat une baisse du taux de testostérone sérique. Le monoxyde de carbone et le plomb présents dans les gaz d'échappement, et détectés au niveau du sang et de la queue des animaux exposés à ces polluants, sont à l'origine de perturbations sexuelles, rénales et hématologiques. * Laboratoire d 'Écophysiologie anima le, Faculté des AbstractThe automotive exhaust gases constitute an important source of urban pollution. The objectiv e of this study is to explore, in the rat, the effects of repetitive exposure to gasoline automotive exhaust gases on the leve l va riatio ns of serum testosterone, blood lead, bone lead, blood carbon monoxide, on the kidney function and blood parameters.200 rats inhaling a mixture of air and automotive exhaust gas (10/1 , v/v) , are distributed in 4 groups treated during 15, 30, 45 and 60 days. They are compared to non treated controls.Our results show a decrease of serum testosterone level. This result is the origin of a masculine sterility already demonstrated in our laboratory. This sterility seems to be reversible because polluted rats regain their sexual activity , 2 months alt er stopping of the pollutant treatment. An increase of the blood carbon monoxide level with a lead accumulation in blood and in the tail is noticed. Biochemical analyses show that glycaemia, urea, and creatininaemia increase in treated animais. The urinary rate of creatinine decreases. These results indicate kidney defici...

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Effects of chelating agents on testicular toxicity in mice caused by acute exposure to nickel

Cited by 41 publications

References 23 publications

Reproductive toxicology of nickel – Review

Reproductive toxicology of nickel – Review

Gastrointestinal and tissue levels of nickel in deer micePeromyscus maniculatus and woodratsNeotoma fuscipes from serpentine and nonserpentine areas

Impact de l'exposition chronique aux gaz d'échappement d'origine automobile sur certains biomarqueurs touchant la fonction hormonale sexuelle mâle, la fonction rénale et l'hémogramme chez le rat

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