Effects of CDP-choline administration on learning and memory in REM sleep-deprived rats

Çakır, Ayşen; Öcalan, Büşra; Koçoğlu, Sema Serter; Suyen, Guldal Gulec; Cansev, Mehmet; Kahveci, Nevzat

doi:10.1016/j.physbeh.2019.112703

Cited by 5 publications

(5 citation statements)

References 127 publications

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“…Citicoline is an endogenous nucleotide comprising cytidine and choline. Studies have demonstrated that Cit exerts cardiovascular, metabolic, neuroendocrine, and urinary effects in the body (12). Various research findings indicate that this substance prevents the elevation of thiobarbituric acid reactive substances (TBARS) levels and may also decrease levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in individuals exposed to NaAsO 2 poisoning (7).…”

Section: Citicolinementioning

confidence: 99%

Protective Effect of Citicoline on Sodium Arsenite-Induced Nephrotoxicity in Mice

Khodayar,

Shirani,

Nikravesh

et al. 2024

Jundishapur J Nat Pharm Prod

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Background: Sodium arsenite (NaAsO2) is a common mineral contaminant in drinking water in numerous parts of the world. It has been shown to have cardiovascular, metabolic, neuroendocrine, and urinary effects on the body. There is abundant scientific evidence that establishes a strong correlation between arsenic exposure and kidney-related disorders. Objectives: The present study aimed to investigate the potential protective effect of citicoline against NaAsO2-induced nephrotoxicity. Methods: The groups included a control group, a group treated with NaAsO2 at a concentration of 50 ppm, a group treated with Cit at a dosage of 1000 mg/kg, and three groups of NaAsO2 (50 ppm) co-treated with Cit at doses of 250, 500, and 1000 mg/kg, respectively. Results: Citicoline decreased the activity level of blood urea nitrogen (P < 0.001), creatinine levels (P < 0.001), thiobarbituric acid reactive substances (P < 0.001), nitric oxide (P < 0.001), inflammatory factors such as tumor necrosis factor-α (P < 0.001) and interleukin-6 (P < 0.001 and P < 0.001). Furthermore, Cit increased total thiol (P < 0.001) and activity levels of catalase (P < 0.05 and P < 0.001), superoxide dismutase (P < 0.01 and P < 0.001), and glutathione peroxidase (P < 0.001). Therefore, Cit reduced the harmful effects caused by the imbalance in oxidative and antioxidant systems and histopathological damage in NaAsO2-intoxicated mice, improving the damage caused by oxidative stress and inflammation. Conclusions: Our research indicates that Cit can shield the kidneys from the damaging effects of NaAsO2 by leveraging its antioxidant and anti-inflammatory properties.

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Section: Citicolinementioning

confidence: 99%

Protective Effect of Citicoline on Sodium Arsenite-Induced Nephrotoxicity in Mice

Khodayar,

Shirani,

Nikravesh

et al. 2024

Jundishapur J Nat Pharm Prod

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“…Cakir et al [ 380 ] investigated the effects of citicoline on the well-known negative effects of rapid eye movements sleep deprivation on learning and memory in adult male Wistar albino rats, and the results obtained suggest that citicoline reduces rapid eye movements sleep deprivation-induced impairment in memory, at least in part, by counteracting the disturbances in biochemical and molecular biological parameters.…”

Section: Pharmacological Actionsmentioning

confidence: 99%

“…Cakir et al [ 380 ] investigaron los efectos de la citicolina sobre los conocidos efectos negativos de la privación del sueño con movimientos oculares rápidos sobre el aprendizaje y la memoria en ratas albinas Wistar macho adultas, y los resultados obtenidos sugieren que la citicolina reduce el deterioro inducido por la privación del sueño con movimientos oculares rápidos en la memoria, al menos en parte, contrarrestando las alteraciones en los parámetros bioquímicos y biológicos moleculares.…”

Section: Acciones Farmacológicasunclassified

Citicolina: revisión farmacológica y clínica, actualización 2022

Ruiz¹,

Gareri²

2022

RevNeurol

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Resumen Esta revisión se basa en la publicada en 2016 –Secades JJ. Citicolina: revisión farmacológica y clínica, actualización 2016. Rev Neurol 2016; 63 (Supl 3): S1-S73–, e incorpora 176 nuevas referencias aparecidas desde entonces, con toda la información disponible para facilitar el acceso a toda la información en un único documento. La revisión se centra en las principales indicaciones del fármaco, como los accidentes cerebrovasculares agudos y sus secuelas, incluyendo el deterioro cognitivo, y los traumatismos craneoencefálicos y sus secuelas. Se recogen los principales aspectos experimentales y clínicos en estas indicaciones.

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“…It has also been shown that slow wave sleep restriction or RSD does not affect sleep-dependent memory consolidation (Genzel et al, 2009[ 27 ]). RSD does not impair spatial learning in the Morris water maze task in rats (Cakir et al, 2020[ 15 ]). A previous study has reported that RSD does not block re-consolidation of fear conditioning (Tian et al, 2009[ 107 ]).…”

Section: Sd and Memorymentioning

confidence: 99%

“…A better performance in a verbal memory test in sleep restricted children has also been shown in a past study (Randazzo et al, 1998[ 88 ]) (Table 2 (Tab. 2) ; References in Table 2: Azogu et al, 2015[ 10 ]; Biggs et al, 2010[ 12 ]; Cakir et al, 2020[ 15 ]; Cheng et al, 2015[ 19 ]; Giacobbo et al, 2016[ 29 ]; Gisquet-Verrier and Smith, 1989[ 30 ]; Hennecke et al, 2020[ 41 ]; Hussaini et al, 2009[ 42 ]; Mahboudi et al, 2019[ 64 ]; Morgenthaler et al, 2014[ 73 ]; Randazzo et al, 1998[ 88 ]; Rangtell et al, 2019[ 89 ]; Voderholzer et al, 2011[ 114 ]; Zhang et al, 2020[ 127 ]).…”

Section: Sd and Memorymentioning

confidence: 99%