Effects of cardiopulmonary bypass temperature on pulmonary gas exchange after coronary artery operations

The Influence of Cardiopulmonary By-pass on Respiratory Function in Patients Who Underwent Coronary Disease Surgery

“…There was a decrease in alveolar-arterial oxygen difference during the stay of patients on the intensive care unit at the reference level, for patients who had no CPB, while the value of (A-a)DO2 in the group of patients operated using CPB remain at all times 300% or more above the reference values. Similar results were obtained by Birdi et al which stated that the increase in (A-a)DO2 value is good indicator of lung damage in patients treated with the use of CPB's (13). Another important parameter values is low ALI hypoxemia scores PaO2/ FiO2.…”

Comparison of the effects of pulsatile cardiopulmonary bypass, non-pulsatile cardiopulmonary bypass and off-pump coronary artery bypass grafting on the respiratory system and serum carbonyl

“…17,18 Moreover, increased pulmonary vascular resistance is frequently observed after CPB. Several studies 18,19 have shown that the increase in interstitial fluid observed following bypass leads to a reduction in pulmonary compliance, a reduction in tidal volume and a subsequent increase in the respiratory rate to maintain alveolar ventilation. Total pulmonary volume and all functional parameters are diminished.…”

Oxygenation within the first 120 h following coronary artery bypass grafting. Influence of systemic hypothermia (32 °C) or normothermia (36 °C) during the cardiopulmonary bypass: a randomized clinical trial

“…The influence of temperature on the post‐ operative oxygenation up to 24 h following CPB has previously been investigated in three randomized clinical trials (7–9), with all demonstrating significant short‐term changes in oxygenation. However, conflicting results have been obtained with regard to the significance of CPB temperature.…”

“…This effect would not be seen in the initial phase, when lung collapse is dominating, but somewhat later. Previous randomized studies of normothermic and hypothermic CPB have only examined oxygenation up to the first post‐operative day; furthermore, the results have been conflicting: either no differences were found between the two modalities or normothermia was found to have a beneficial effect on oxygenation (7–9). In observational studies following cardiac surgery performed with hypothermic CPB, the arterial oxygen tension ( P a o 2 ) was impaired for several days, with the nadir value on the second post‐operative day (2, 10).…”