Effects of Breastfeeding on Endometriosis-Related Pain: A Prospective Observational Study

Porta, Romana Prosperi; Sangiuliano, Chiara; Cavalli, Alessandra; Pereira, Laila Cristine Hirose Marques; Masciullo, Luisa; Piacenti, Ilaria; Scaramuzzino, Sara; Viscardi, Maria Federica; Porpora, Maria Grazia

doi:10.3390/ijerph182010602

Cited by 5 publications

(10 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with a history of delivery might have breastfed their infants. Breastfeeding can cause hormonal changes that may relieve pain and reduce endometriosis recurrence [ 35 ]. Indeed, patients with a delivery history had lower scores at 1 month prior to the start of treatment, suggesting a better baseline HRQL, compared with those without a delivery history and, therefore, less potential for improvement in HRQL with EE/DRSP.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Japanese Patients with Dysmenorrhea or Endometriosis-Associated Pelvic Pain Treated with Extended Regimen Ethinylestradiol/Drospirenone in a Real-World Setting: A Prospective Observational Study

et al. 2022

View full text Add to dashboard Cite

Introduction Dysmenorrhea and endometriosis are common gynecologic disorders among women of reproductive age that significantly impact health-related quality of life (HRQL) as well as productivity. Although there are treatment options listed in Japanese guidelines, a gap remains in unmet medical needs for maximizing treatment outcome. The extended regimen of ethinylestradiol and drospirenone (EE/DRSP) (taken daily for up to 120 consecutive days) has been available in Japan for treating dysmenorrhea and/or endometriosis-associated pain since 2016. Yet, the effectiveness of its usage on HRQL has not been investigated elsewhere to date. Therefore, in this study, we aim to observe changes in HRQL of Japanese women treated with an extended regimen of EE/DRSP for dysmenorrhea and/or endometriosis-associated pain. Methods As part of a 2-year post-marketing surveillance study, women with dysmenorrhea or endometriosis-associated pelvic pain were prescribed extended EE/DRSP during routine clinical practice. Data were collected 1 month before and 3 and 6 months after initiating treatment. Primary outcomes were the Menstrual Distress Questionnaire (MDQ) (before, during, and after menstruation) in patients with dysmenorrhea, and the Endometriosis Impact Scale (EIS) and European Quality of Life 5-dimensions 5-level instrument (EQ-5D-5L) in patients with endometriosis. Results The study cohort included 315 patients (mean age 28.9 years) with dysmenorrhea and 262 patients (mean age 31.3 years) with endometriosis. Mean MDQ total scores before and during menstruation decreased significantly after 6 months with extended EE/DRSP; there was no improvement in after-menstruation MDQ score. Mean EIS domain scores improved significantly by 6 months, with improvement in most EIS individual item scores. Mean EQ-5D-5L scores increased slightly during 6 months of treatment. Conclusions Extended EE/DRSP treatment improved HRQL outcomes in Japanese women with dysmenorrhea or endometriosis-associated pelvic pain. Trial Registration Registered at ClinicalTrials.gov (NCT03126747) on June 2017. Supplementary Information The online version contains supplementary material available at 10.1007/s12325-022-02301-3.

show abstract

Section: Discussionmentioning

confidence: 99%

Quality of Life in Japanese Patients with Dysmenorrhea or Endometriosis-Associated Pelvic Pain Treated with Extended Regimen Ethinylestradiol/Drospirenone in a Real-World Setting: A Prospective Observational Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Обратную связь между риском развития другого эстрогензависимого женского недуга репродуктивного возраста (эндометриоза) с грудным вскармливанием продемонстрировали иранские коллеги в 2022 г., проанализировав результаты 18 исследований по этой теме, призвав к вниманию ответственных за политику в сфере пропаганды грудного вскармливания [32]. Romana Prosperi Porta et al (Италия), изучив истории 156 беременных женщин с эндометриозом, заключили, что грудное вскармливание, особенно исключительное, вызывает улучшение клинических проявлений эндометриоза (дисменореи и хронической тазовой боли), а также уменьшение размеров эндометриом яичников пропорционально своей продолжительности [33]. Защитный эффект длительного грудного вскармливания также был высоко оценен по итогам метаанализа 2015 г., изучаю щего его связь с раком эндометрия (РЭ).…”

Section: грудное вскармливание и риск развития онкологииunclassified

Prenatal nursing care is essential! Breastfeeding: focus on maternal health

Zakharova,

Kuchina,

Kholodova

et al. 2023

Medicinskij sovet

View full text Add to dashboard Cite

This article deals with the importance and necessity of breastfeeding for both mother and baby. The timeliness of this topic has been brought about by technological advances, which imposes its own rules and offers alternatives in which it seems much easier to neglect the main maternal responsibility – the role of the breastfeeding mother. One gets the feeling that scientific research into breast milk is limited to finding evidence of the benefits of breastfeeding to convince novice mothers to breastfeed. The article mentions the evolutionary significance of breastfeeding, explains the reasons for the mammary glands “suffering” if the only “evolutionarily assigned” function for this female organ is not implemented, which makes us look at the need for natural breastfeeding from a different angle. Evidence of the need for breastfeeding to prevent the development of breast cancer that has high mortality rates in the female population is presented. At the same time, the issue of malignant tumours is not limited only to the mammary glands. The role of the breast milk microbiota disorders in the formation of the above processes is discussed. The preventive role of breastfeeding in the development of metabolic disorders, cardiovascular and endocrine diseases in women has been shown. The article presents data on this issue from numerous clinical studies, reviews and meta-analyses. The emphasis was placed on the prenatal discussions with pregnant women about the importance and necessity of breastfeeding, which should be carried out at the stage of preparing women for childbirth. The question has been raised about the role of the local paediatrician in the prenatal nursing care for women. It explains why “early” acquaintance with the mother is far from being an additional needless burden for the local paediatrician, as it might seem at first glance, but rather, on the contrary, additional opportunities.

show abstract

“…1,23 Due to hormonal changes, pregnancy has a beneficial influence on endometriosis and its related discomfort. 50 Endometriosis is influenced by physiological mechanisms such as breastfeeding; and the length and type of breastfeeding are considered as important factors. 50 Breastfeeding may reduce the risk of endometriosis or be found to have protective effects.…”

Section: Socio-economic Demographic and Lifestyle Determinants Of End...mentioning

confidence: 99%

“…50 Endometriosis is influenced by physiological mechanisms such as breastfeeding; and the length and type of breastfeeding are considered as important factors. 50 Breastfeeding may reduce the risk of endometriosis or be found to have protective effects. 8,50 Benefits of breastfeeding may result from how it influences pituitary hormonal activity, which reduces circulating estrogen levels.…”

Section: Socio-economic Demographic and Lifestyle Determinants Of End...mentioning

confidence: 99%

Global risks of endometriosis in women – an appraisal

Roy¹,

Mondal²

2023

Eur J Clin Exp Med

View full text Add to dashboard Cite

Introduction and aim. Endometriosis is a complex condition in which endometrium, tissue that resembles the uterine lining, develops outside the uterus. It is considered to be a chronic, estrogen-dependent, inflammatory gynecological disorder having multi-factorial origins. This review paper aims to consolidate recent information on ethnic differences, endometriosis risks, and the disease’s etiology in the global context. Material and methods. A systematic search was performed using a variety of international electronic databases, including “PubMed” and “DOAJ”, using the terms endometriosis, endometriosis and infertility, endometriosis and cancer, and treatment of endometriosis. Analysis of the literature. Endometriosis can appear anywhere in the body, including the umbilicus, the cecum and ileum of the digestive tract, the breast, the lungs, and the genitourinary organs. It is typically clinically asymptomatic with no obvious clinical manifestation and expensive treatment, which makes the diagnosis late. There is a complex interplay between socioeconomic status, family history, societal beliefs and laws, personal habits, reproductive and gynaecological conditions, and environmental influences in the development of endometriosis. Conclusion. Women with endometriosis should be given more attention, and specific resources in the healthcare system should be utilized to provide more efficient multidisciplinary healthcare and treatment.

show abstract

Effects of Breastfeeding on Endometriosis-Related Pain: A Prospective Observational Study

Cited by 5 publications

References 55 publications

Quality of Life in Japanese Patients with Dysmenorrhea or Endometriosis-Associated Pelvic Pain Treated with Extended Regimen Ethinylestradiol/Drospirenone in a Real-World Setting: A Prospective Observational Study

Quality of Life in Japanese Patients with Dysmenorrhea or Endometriosis-Associated Pelvic Pain Treated with Extended Regimen Ethinylestradiol/Drospirenone in a Real-World Setting: A Prospective Observational Study

Prenatal nursing care is essential! Breastfeeding: focus on maternal health

Global risks of endometriosis in women – an appraisal

Contact Info

Product

Resources

About