Effects of Bovine α-Lactalbumin on Gastric Defense Mechanisms in Naive Rats

Antiulcerative properties of bovine α-lactalbumin

“…On the other hand the vascular permeabilization and vasodilation property of PGE 2 should be beneficial for a faster elimination of ethanol from the mucosa. Previously reported work (Ushida et al, 2003) showed an increase of 158% PGE 2 in the gastric mucosa, 30 min after administration of an oral dose (200 mg kg À1 bw) of a-La.…”

“…a-Lactalbumin (a-La) has recently been associated with reduction of stress (Markus et al, 2000), immunomodulation (Montagne, Cuiliere, Mole, Bene, & Faure, 2000), antimicrobial activity (Pelligrini, Thomas, Bramaz, Hunziker, & Fellenberg, 1999;Pihlanto-Leppa¨la¨et al, 1999), bactericidal and apoptotic activity Svensson, Hakansson, Mossberg, Linse, & Svanborg, 2000), and antiulcer activity (Matsumoto, Shimokawa, Yshida, Toida, & Hayasawa, 2001;Ushida, Shimokawa, Matsumoto, Toida, & Hayasawa, 2003). In addition to its well known activity as enzymatic cofactor in mammary gland synthesis of lactose (Walstra, Geurts, Noomen, Jellema, & van Boekel, 1999).…”

Propriedades fisiológicas-funcionais das proteínas do soro de leite

“…Pesquisas recentes realizadas no exterior e pelo grupo de Campinas [39][40][41] , SP, permitiram concluir que uma das proteínas do soro ativa contra a ulceração gástrica é a ∝-lactalbumina e que a β-lactoglobulina não apresenta ação antiulcerogênica, em ratos.…”

Conformational States and Thermodynamics of α-Lactalbumin Bound to Membranes: A Case Study of the Effects of pH, Calcium, Lipid Membrane Curvature and Charge

“…22 a-Lactalbumin is involved in the protective effect of breastfeeding during childhood, such as protection against some gastric mucosal injuries. 23,24 Proteolytic fragments of a-lactalbumin display antibiotic activities. 25,26 a-Lactalbumin also induces apoptosis in tumour cells while fully differentiated cells remain unaffected.…”