Effects of body condition and leptin on the reproductive performance of Lusitano mares on extensive systems

Fradinho, Maria João; Correia, Maria-Fernanda; Grácio, V.; Bliebernicht, Miguel; Farrim, A.; Mateus, L.; Martin‐Rosset, W.; Bessa, Rui J. B.; Caldeira, Rui; Ferreira‐Dias, Graça

doi:10.1016/j.theriogenology.2014.01.042

Cited by 20 publications

(11 citation statements)

References 44 publications

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“…Nonetheless, in the group of females surveyed, the interovulatory interval and the duration of diestrus were significantly affected by BCS: higher BCS lengthened the interovulatory intervals and diestrus in Asinina de Miranda jennies. Although changes in BCS or in metabolites and metabolic hormones such as leptin, insulin, or insulinlike growth factor 1 have been associated with follicular activity and mare fertility [28,29], there is a lack of incontrovertible information available on the effect of BCS on conditioned measurements of the duration of each stage of the estrous cycle in cyclic mares [30,31].…”

Section: Discussionmentioning

confidence: 99%

Characterization of the estrous cycle of Asinina de Miranda jennies (Equus asinus)

Quaresma

Payan-Carreira

2015

Theriogenology

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This study aims to characterize the estrous cycle of Asinina de Miranda jennies in the breeding season, on the basis of data collected from serial ultrasonographic examination and serum progesterone determinations in 14 females during a total of 33 cycles. The length of the interovulatory interval was 23.8 ± 0.55 days, the diestrus and estrus lasting 17.9 ± 0.46 days and 6.65 ± 0.30 days, respectively. Age and body condition score (BCS) affected the length of the interovulatory intervals; BCS also influenced the diestrus length and the time in heat after ovulation (P > 0.05). The incidence of single, double, and triple ovulations was 57.58%, 36.36%, and 6.06%, respectively. Multiple ovulations affected neither the length of the interovulatory interval nor the individual cycle stages (P > 0.05) but lengthened the interval from the beginning of estrus to the last ovulation (P = 0.01). When combined with age, higher BCS affected the ovulation rate (P = 0.001). Deviation of the dominant follicle occurred around Day 8.7 (Day 0 = ovulation) when both single and multiple ovulations were considered. The dominant follicle was larger at divergence in single ovulators (19.18 ± 0.97 mm) compared with that in multiple ovulators (18.05 ± 1.16 mm). The overall maximum follicular diameter before ovulation was smaller in multiple ovulatory cycles than that in single ovulatory cycles (37.2 ± 0.83 mm vs. 40.2 ± 1.41 mm, respectively; P = 0.03). The daily growth rate of dominant follicles was independent of the ovulation rate (P > 0.05) for the intervals before and after the estrus onset. The dominant follicle size and the follicle growth rates were independent of BCS (P > 0.05). Data collected in this study revealed resemblances between Mirandese and other Iberian and Brazilian breeds with regard to estrous cycle characteristics.

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Section: Discussionmentioning

confidence: 99%

Characterization of the estrous cycle of Asinina de Miranda jennies (Equus asinus)

Quaresma

Payan-Carreira

2015

Theriogenology

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“…Éguas Lusitanas em regime extensivo de criação, com ECC > 2,25 (escala 1 -5) apresentaram aumento das concentrações plasmáticas de leptina no terço final de gestação e queda desses níveis durante o primeiro mês de lactação, porém esta variação não teve efeito sobre o intervalo do parto à concepção, e os resultados de fertilidade ao 1º e 2º ciclos estrais pós-parto (Fradinho et al, 2014). Éguas com ECC moderado (5-6) e alto (7-8), a primeira e segunda ovulação pós-parto, tiveram valores médios similares de leptina durante o ciclo estral, bem como de eficiência reprodutiva (Cavinder et al, 2007).…”

Section: Leptina Condição Corporal E Atividade Reprodutivaunclassified

“…Aparentemente, o grupo de éguas que manteve ECC < 5 utilizou energia de reserva para a produção de leite. Por outo lado, Fradinho et al (2014) relatam que a perda de ECC das éguas, no primeiro trimestre da lactação, teve efeito negativo significativo sobre a taxa de crescimento de seus potros. Kubiak et al (1988) não observaram efeito da obesidade (ECC = 8,5 -9) sobre a parição e peso do potro ao nascer, no entanto, em estudo posterior foi observada uma tendência de éguas obesas apresentarem uma menor produção de leite, com potros significativamente mais leves e com menor perímetro torácico aos 63 dias pós-parto.…”

Section: Condição Corporal E Eficiência Reprodutivaunclassified

Condição corporal e atividade reprodutiva de eguas

et al. 2014

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A manutenção dos animais em boa condição corporal é de grande importância para se alcançar altos índices reprodutivos, tanto à monta natural quanto frente às modernas biotecnologias da reprodução equina. A presente revisão de literatura teve como objetivo abordar a influência da condição corporal sobre a atividade reprodutiva de éguas, enfocando a atividade ovariana, o perfil endócrino, sendo dada ênfase à leptina, pois seus níveis estão diretamente relacionados à condição corporal e envolvidos no estímulo do eixo hipotálamo-hipófise-gônadas, e os índices de eficiência reprodutiva. Considerando uma escala de escore da condição corporal (1 a 9), éguas com escore > 5 são consideradas aptas a apresentarem índices de eficiência reprodutiva satisfatórios. Em síntese, a condição corporal exerce efeito sobre: a duração do anestro estacional e do período interovulatório, a secreção de IGF-1 e leptina, o número de ciclos/concepção, as taxas de prenhez, perda embrionária precoce e aborto. SUMMARYKeeping animals in good body condition is of great importance to achieve high reproductive rates, both the natural mating as the face of modern biotechnologies equine reproduction. This literature review aimed to evaluate the influence of body condition on reproductive activity in mares, focusing on ovarian activity, the endocrine profile, with an emphasis on leptin, because their levels are directly related to body condition and involved in stimulating hypothalamic-pituitary -gonadal axis, and the indices of reproductive efficiency.Considering a range of body condition score (1-9), mares with scores >5 are considered able to submit satisfactory levels of reproductive efficiency. Additionally, the body condition has an effect on the duration of seasonal anestrus, the interovulatory period, the secretion of IGF-1 and leptin, the number of cycles/conception, the pregnancy rates, early embryonic loss and abortion. INTRODUÇÃOEm um programa reprodutivo de equinos espera-se o nascimento de um potro saudável por égua, dentro do intervalo de um ano. Para isso, é necessário que se tenha éguas e garanhões de boa fertilidade, além de manejos reprodutivo, nutricional e sanitário adequados.Para a avaliação da fertilidade são adotados índices de eficiência reprodutiva, que refletem a fertilidade tanto individual como do plantel. Vários estudos vêm sendo realizados visando o aumento da eficiência reprodutiva das éguas, alguns deles com o uso de fármacos (Thompson e Witherspoon, 1974;Alcântara et al., 2005;Meyers-Brown et al., 2013) e de biotecnologias avançadas da reprodução equina (Coutinho da Silva et al., 2004;Meyers-Brown et al., 2011;Nagao et al., 2012

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“…Recent reports demonstrate the expression of LEP and GHR and their receptors in different reproductive organs, such as ovary [8], endometrium [9], embryo, or placenta [10]. In the mare, in vivo LEP effect on seasonal ovarian cyclicity and fertility was previously addressed [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

Opposing Roles of Leptin and Ghrelin in the Equine Corpus Luteum Regulation: AnIn VitroStudy

Galvão

Tramontano

Rebordão

et al. 2014

Mediators of Inflammation

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Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and GHR on progesterone (P4), prostaglandin (PG) E2 and PGF2α, nitric oxide (nitrite), tumor necrosis factor-α (TNF); macrophage migration inhibitory factor (MIF) secretion, and on angiogenic activity (BAEC proliferation), in equine corpus luteum (CL) from early and mid-luteal stages. LEPR expression was decreased in late CL, while GHR/Ghr-R1A system was increased in the same stage. Regarding secretory activity, GHR decreased P4 in early CL, but increased PGF2α, nitrite and TNF in mid CL. Conversely, LEP increased P4, PGE2, angiogenic activity, MIF, TNF and nitrite during early CL, in a dose-dependent manner. The in vitro effect of LEP on secretory activity was reverted by GHR, when both factors acted together. The present results evidence the presence of LEP and GHR systems in the equine CL. Moreover, we suggest that LEP and GHR play opposing roles in equine CL regulation, with LEP supporting luteal establishment and GHR promoting luteal regression. Finally, a dose-dependent luteotrophic effect of LEP was demonstrated.

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Effects of body condition and leptin on the reproductive performance of Lusitano mares on extensive systems

Cited by 20 publications

References 44 publications

Characterization of the estrous cycle of Asinina de Miranda jennies (Equus asinus)

Characterization of the estrous cycle of Asinina de Miranda jennies (Equus asinus)

Condição corporal e atividade reprodutiva de eguas

Opposing Roles of Leptin and Ghrelin in the Equine Corpus Luteum Regulation: AnIn VitroStudy

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