Effects of black adzuki bean (Vigna angularis, Geomguseul) extract on body composition and hypothalamic neuropeptide expression in rats fed a high-fat diet

Abstract

BackgroundObesity is often considered to result from either excessive food intake or insufficient physical activity. Adzuki beans have been evaluated as potential remedies for various health conditions, and recent studies have reported their effects on the regulation of lipid metabolism, but it remains to be determined whether they may be effective in overcoming obesity by regulating appetite and satiety.ObjectiveThis study investigated the effect of black adzuki bean (BAB) extract on body composition and hypothalamic neuropeptide expression in Sprague Dawley rats (Rattus norvegicus) fed a high-fat diet.DesignThe rats were fed for 8 weeks with a control diet containing 10 kcal% from fat (CD), a high-fat diet containing 60 kcal% from fat (HD), or a high-fat diet with 1% or 2% freeze-dried ethanolic extract powder of BAB (BAB-1 and BAB-2).ResultsThe body weights and epididymal fat weights were significantly reduced and the serum lipid profiles were improved in the group fed the diet containing BAB compared to the HD group. The expression of AGRP mRNA significantly decreased in the BAB groups, and treatment with BAB-2 resulted in a marked induction of the mRNA expression of POMC and CART, which are anorexigenic neuropeptides that suppress food intake. Furthermore, mRNA expression levels of ObRb, a gene related to leptin sensitivity in the hypothalamus, were significantly higher in the BAB groups than in the HD group.ConclusionsThese results suggest that supplementation with BAB has a significant effect on body weight via regulation of hypothalamic neuropeptides.

Prebiotic potential and other health benefits of prebiotic mixture of pigeon pea (Cajanus cajan L) in Wistar NIN rats

“…The overall body mass and the epidermal fat mass were remarkably lowered. In comparison with the high-fat diet fed animals, the serum lipid pro les of the animals supplemented with the BAB (black adzuki bean) containing diet was enhanced [31]. In a study, when experimental rats fedona high-cholesterol diet were supplemented with encased symbiotic microbes, it exponentially lowered the LDL-cholesterol compared to every one of the other groups, and also highly increased the HDL-cholesterol levels [32].…”

Adzuki bean (Vigna angularis): Chemical compositions, physicochemical properties, health benefits, and food applications

“…These effects were related to the down‐regulation of lipogenic and lipolysis‐related transcriptional factors and the up‐regulation of fatty acid oxidation‐related transcriptional factors (Kim et al., 2017; Lee et al., 2019). Furthermore, reduced food intake was observed in different murine models, which might be attributed to the regulation of the hypothalamic neuropeptide expression (Kim et al., 2015). Specifically, the increased leptin sensitivity induced by the increased expression of leptin receptor (ObRb) down‐regulated the orexigenic neuropeptides and up‐regulated the anorexigenic neuropeptides, resulting in the induction of satiety and suppression of appetite (Kim et al., 2015).…”

“…Furthermore, reduced food intake was observed in different murine models, which might be attributed to the regulation of the hypothalamic neuropeptide expression (Kim et al., 2015). Specifically, the increased leptin sensitivity induced by the increased expression of leptin receptor (ObRb) down‐regulated the orexigenic neuropeptides and up‐regulated the anorexigenic neuropeptides, resulting in the induction of satiety and suppression of appetite (Kim et al., 2015). It was found that the administration of adzuki bean pastes and extracts could decrease the ratio of Firmicutes to Bacteroidetes (Han, Ohashi, et al., 2020; Lee et al., 2019).…”

Dietary Polyphenols to Combat Nonalcoholic Fatty Liver Disease via the Gut–Brain–Liver Axis: A Review of Possible Mechanisms

“…Polyphenols regulate NAFLD by impacting the bile acid metabolism via “cross-talk” among the liver, the brain, and the gut. , BAs cross the BBB and bind to FXR/TGR5 receptors in the brain and inhibit hypothalamic inflammation, thereby weakening NAFLD. Furthermore, BAs can directly bind to FXR/TGR5 receptors in the gut and correspondingly lead to the release of FGF15/GLP-1, which affects the appetite through the hypothalamic signaling pathway, thereby leading to the reduction of FFAs and TG in the liver.…”

“…Figure 6. Polyphenols regulate NAFLD by impacting the bile acid metabolism via "cross-talk" among the liver, the brain, and the gut 60,122. BAs cross the BBB and bind to FXR/TGR5 receptors in the brain and inhibit hypothalamic inflammation, thereby weakening NAFLD.…”