Effects of bisphenol A on breast cancer and its risk factors

Yang, Mihi; Ryu, Jae‐Ha; Jeon, Raok; Kang, Daehee; Yoo, Keun-Young

doi:10.1007/s00204-008-0364-0

Cited by 132 publications

(78 citation statements)

References 15 publications

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“…The urinary levels of PMs and BPA in these control individuals have been reported previously Geens et al, 2015). Control data for adult serum values were reproduced from referenced literature (Dirtu et al, 2008;Frederiksen et al, 2010;Yang et al, 2009).…”

Section: Study Populationmentioning

confidence: 99%

Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-A in intensive care unit (ICU) patients

Huygh

Clotman

Malarvannan

et al. 2015

Environment International

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Section: Study Populationmentioning

confidence: 99%

Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-A in intensive care unit (ICU) patients

Huygh

Clotman

Malarvannan

et al. 2015

Environment International

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“…Seventeen studies have measured BPA in blood and serum samples from healthy male and nonpregnant female adults (Dirtu et al 2008;Fung et al 2000;He et al 2009;Hiroi et al 2004;Ikezuki et al 2002;Inoue et al 2000Inoue et al , 2001Kaddar et al 2009;Kuroda et al 2003;Liu et al 2007;Sajiki et al 1999;Sugiura-Ogasawara et al 2005;Takeuchi and Tsutsumi 2002;Takeuchi et al 2004;Volkel et al 2005;Yang M et al 2009;Yoshimura et al 2002) (Table 3). Of these studies, five used ELISA, one used a radioimmunoassay (RIA), and the remainder used analytical chemistry to assess BPA concentrations.…”

Section: Internal Dosage Assessment From Blood Measures Of Bpamentioning

confidence: 99%

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

331

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Estudos de biomonitoração do sistema urinário, circulatório e tecidos indicam grande exposição ao Bisfenol A Resumo Bisfenol A (BPA) é um dos produtos quí-micos mais produzido em todo o mundo, e a exposição humana a ele é considerada onipresente. Assim, há preocupações de que a quantidade de BPA para o qual os seres humanos estão expostos podem causar efeitos adversos à saúde. Nós examinamos muitas possibilidades sobre o porquê estudos de biomonitorização e toxicocinética podem chegar a conclusões aparentemente conflitantes. Mais de 80 estudos publicados de biomonitorização humana que mediram a concentração de BPA em tecidos humanos, urina, sangue e outros fluidos, juntamente com dois estudos de toxicocinéti-ca do metabolismo humano BPA foram examinados. BPA não conjugado foi detectado no sangue (nonanogramas por mililitro gama), e BPA conjugado foi detectado na grande maioria das amostras de urina. Em contraste, estudos de toxico-cinética propuseram que os seres humanos não são internamente expostos ao BPA. Dados disponíveis de estudos de biomonitorização indicam que a população em geral está exposta ao BPA e em risco de exposição interna ao BPA não conjugado. Os dois estudos de toxicocinética, que sugeriram a exposição humana ao BPA é insignificante, têm deficiências significativas e estão diretamente refutados por outros estudos e, portanto não são confiáveis para fins de avaliação de risco. Palavras-chave Disruptor endócrino, Exposição humana, Modelo PBPK/PBTK, Gravidez, Avaliação de risco, Toxicocinética Abstract Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.

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“…E-mail: ana.soto@tufts.edu. BPA concentrations and breast cancer incidence (37), exposure to the synthetic estrogen DES increased the risk of breast cancer (38). Additionally, women under 14 years of age who were exposed to the estrogenic pesticide DDT have five times greater risk of developing breast cancer (39), suggesting that mammary glands are organs sensitive to estrogenic chemicals across species.…”

mentioning

confidence: 99%

Bisphenol A alters the development of the rhesus monkey mammary gland

Tharp

Maffini

Hunt

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

152

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The xenoestrogen bisphenol A (BPA) used in the manufacturing of various plastics and resins for food packaging and consumer products has been shown to produce numerous endocrine and developmental effects in rodents. Exposure to low doses of BPA during fetal mammary gland development resulted in significant alterations in the gland's morphology that varied from subtle ones observed during the exposure period to precancerous and cancerous lesions manifested in adulthood. This study assessed the effects of BPA on fetal mammary gland development in nonhuman primates. Pregnant rhesus monkeys were fed 400 μg of BPA per kg of body weight daily from gestational day 100 to term, which resulted in 0.68 ± 0.312 ng of unconjugated BPA per mL of maternal serum, a level comparable to that found in humans. At birth, the mammary glands of female offspring were removed for morphological analysis. Morphological parameters similar to those shown to be affected in rodents exposed prenatally to BPA were measured in whole-mounted glands; estrogen receptor (ER) α and β expression were assessed in paraffin sections. Student's t tests for equality of means were used to assess differences between exposed and unexposed groups. The density of mammary buds was significantly increased in BPA-exposed monkeys, and the overall development of their mammary gland was more advanced compared with unexposed monkeys. No significant differences were observed in ER expression. Altogether, gestational exposure to the estrogen-mimic BPA altered the developing mammary glands of female nonhuman primates in a comparable manner to that observed in rodents.endocrine disruptor | perinatal exposure | morphogenesis | internal dose | mammogenesis

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Effects of bisphenol A on breast cancer and its risk factors

Cited by 132 publications

References 15 publications

Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-A in intensive care unit (ICU) patients

Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-A in intensive care unit (ICU) patients

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Bisphenol A alters the development of the rhesus monkey mammary gland

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