Effects of Biotin Supplementation on Peripartum Performance and Metabolites of Holstein Cows

Rosendo, Oswaldo; Staples, C.R.; McDowell, L. R.; McMahon, Robert J.; Badinga, L.; Martin, F. G.; Shearer, J.F.; Seymour, W.M.; Wilkinson, N. S.

doi:10.3168/jds.s0022-0302(04)73378-0

Cited by 44 publications

(49 citation statements)

References 28 publications

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“…Reasons for the increase in jugular vein plasma glucose concentration reported by Bonomi et al (1996) and Rosendo et al (2004) are not certain. An increased supply of oxaloacetate via a stimulation of carboxylase activity in the liver would only be used for glucose synthesis if the additional oxaloacetate was required (Reynolds, 1995).…”

Section: Discussionmentioning

confidence: 93%

“…Therefore, DM offered was restricted to just below ad libitum and not altered over the course of the study to reduce variation in nutrient absorption and metabolism by splanchnic tissues attributable to DMI. In dairy cows fed ad libitum, supplemental biotin has typically increased milk yield (Bonomi et al, 1996;Midla et al, 1998;Zimmerly and Weiss, 2001;Bergsten et al, 2003;Majee et al, 2003) but the effect has not been observed in every study reported (Fitzgerald et al, 2000;Rosendo et al, 2004). In the present study, the lack of a milk yield response to supplemental biotin may have been due to the restricted DMI of the cows, or the length of supplementation (14 days) may have been too short to allow for effects on milk yield.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, studies in lactating dairy cows have consistently demonstrated a positive effect of supplemental biotin on hoof growth, integrity, and the incidence of lameness (Midla et al, 1998;Fitzgerald et al, 2000;Hedges et al, 2001;Bergsten et al, 2003). In some of these studies (Midla et al, 1998;Bergsten et al, 2003) and others (Bonomi et al, 1996;Zimmerly and Weiss, 2001;Majee et al, 2003), supplemental biotin also increased milk yield, although the effect was not consistent across all studies (Fitzgerald et al, 2000;Rosendo et al, 2004). Although improved hoof health would ultimately benefit both drymatter intake and milk yield, the response in milk yield to supplemental biotin is more rapid than improvements in hoof integrity, and can occur without changes in DMI (Zimmerly and Weiss, 2001), suggesting a metabolic effect.…”

Section: Introductionmentioning

confidence: 99%

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Net nutrient absorption and liver metabolism in lactating dairy cows fed supplemental dietary biotin

Reynolds

Beever

Steinberg³

et al. 2007

Animal

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The effect of feeding supplemental biotin on net absorption and metabolism of nutrients by the portal-drained viscera (PDV; the gut, pancreas, spleen and associated fat) and liver of lactating dairy cows was measured. Three cows in early to mid-lactation catheterised for measurements of net nutrient absorption and metabolism by the PDV and liver were fed a total-mixed ration with or without supplemental biotin at 20 mg/day using a switch-back design (ABA v. BAB) with three 2-week periods. There were no effects of feeding biotin on dry matter intake (22.2 kg/day), milk yield (29.5 kg/day) or milk composition. There was also no effect of feeding biotin on net release of glucose by the liver, net liver removal of glucose precursors (propionate, alanine, lactate) or net liver release of b-hydroxybutyrate. Feeding biotin increased net PDV release of ammonia. Reasons for the response are not certain, but a numerical increase in net PDV release of acetate suggests that rumen or hindgut fermentation was altered. Results of the present study do not support the hypothesis that supplemental biotin increases liver glucose production in lactating dairy cows.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Net nutrient absorption and liver metabolism in lactating dairy cows fed supplemental dietary biotin

Reynolds

Beever

Steinberg³

et al. 2007

Animal

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“…Moreover, other studies have shown that dairy cows could in fact benefit from biotin supplementation, most of those studies used a daily dietary supplementation of 20 mg of biotin. Table 1 shows the effects of biotin supplementation on the production performance of dairy cows in studies specifically designed for that purpose (Bonomi et al 1996;Zimmerly and Weiss 2001;Majee et al 2003;Rosendo et al 2004) and in studies focusing on foot lesions (Cooke and Brumby 1982;Midla et al 1998;Fitzgerald et al 2000;Bergsten et al 2003). In summary, supplementary biotin was found to increase milk yield in five out of eight studies.…”

Section: Vitamin B 12mentioning

confidence: 99%

Impact of B-vitamin supply on major metabolic pathways of lactating dairy cows

Girard¹,

Matte²

2006

Can. J. Anim. Sci.

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Girard, C. L. and Matte, J. J. 2006. Impact of B-vitamin supply on major metabolic pathways of lactating dairy cows. Can. J. Anim. Sci. 86: 213-220. Knowledge of the major nutrient requirements of dairy cows has increased substantially during the past decades. Little is known, however, about the importance of the roles played by B vitamins. Since most of those vitamins act as essential cofactors in energy, protein and lipid metabolism, it is likely that as milk yield increases, the demand for these cofactors also increases. The supply of B vitamins from dietary sources and synthesis by the ruminal microflora is generally sufficient to avoid deficiency symptoms, but could be insufficient for optimizing metabolic efficiency, production, composition and the nutritional quality of milk in high-producing dairy cows. Results from recent experiments show how the supply of three B vitaminsfolic acid, biotin and vitamin B 12 -affects major metabolic pathways. Supplementary biotin has frequently been reported to increase milk yield but has a limited effect on milk composition. Folic acid supplements have been found to increase milk and milk protein yields in multiparous cows without affecting dry matter intake when vitamin B 12 supply was adequate. An insufficient vitamin B 12 supply blocked those effects but they can be restored through vitamin B 12 supplementation. Supplemental vitamin B 12 and biotin increased milk and milk protein yields without changing dry matter intake. Vitamin B 12 utilization by tissues increased in cows fed supplementary folic acid simultaneously; plasma glucose also increased in these cows but plasma biotin decreased. From these findings, it appears that, in high-producing dairy cows, especially in early lactation, the strong competition for nutrients that occurs between gluconeogenesis, methylneogenesis and protein synthesis increases the amount of folic acid, vitamin B 12 and biotin required to maintain metabolic efficiency, especially when the nutrient supply is limited. These observations emphasize the need to review the paradigm according to which B-vitamin supply by ruminal microflora cannot be limiting in dairy cow. Les connaissances sur les besoins des vaches laitières en nutriments majeurs ont augmentées substantiellement au cours des dernières décennies. Cependant, on connaît encore peu l'importance des rôles des vitamines B. La plupart de ces vitamines sont des cofacteurs essentiels dans les métabolismes énergétiques, protéiques et lipidiques, il est donc probable que la demande pour ces cofacteurs augmente avec la production laitière. Les apports en vitamines B provenant de l'alimentation et de la synthèse par la microflore du rumen suffisent généralement à éviter les symptômes de déficience mais sans nécessairement permettre d'optimiser l'efficacité métabolique, la production, la composition et la qualité nutritionnelle du lait chez les vaches hautes productrices. Les résultats d'expériences récentes mettent en évidence l'impact sur les voies métaboliques majeures des apports en tr...

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“…Ferreira et al (2007) stressed that supplementary biotin was more likely to increase milk and milk component yields in highproducing cows than in low-producing ones because the metabolic demand was greater in the former. Nevertheless, in some studies, high-producing cows did not respond to biotin supplementation (Rosendo et al, 2004). In 2011, two meta-analyses on the effects of dietary supplements of biotin on milk production and composition of Holstein dairy cows were published (Chen et al, 2011;Lean and Rabiee, 2011).…”

Section: Biotinmentioning

confidence: 99%

New approaches, development, and improvement of methodologies for the assessment of B-vitamin requirements in dairy cows

Girard

2017

R. Bras. Zootec.

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-Studies on B-vitamin requirements of cattle, conducted more than 60 years ago, concluded that mature ruminants do not require B-vitamin supplements because the amounts of vitamins provided by the diet and synthesized by the ruminal microflora were sufficient to prevent emergence of deficiency symptoms. As a result, the impact of subclinical deficiency on maintenance of normal and efficient metabolism has been disregarded and very little research effort has been devoted at defining dairy cow requirements for B vitamins. However, emergence of deficiency symptoms is the last stage of the deficiency; deficiency appears as soon as the supply is inferior to the needs, leading to a loss of metabolic efficiency. As B vitamins play critical roles in carbohydrate, protein, and lipid metabolism, it is likely that the demand for these cofactors increases with milk yield. Reports over the last two decades of beneficial effects of B-vitamin supplementation, such as thiamin, niacin, biotin, folic acid, and vitamin B 12 , suggested that, under some conditions, the need for B vitamins exceeds the supply from the diet and the synthesis by rumen microbes, leading to sub-optimal milk production and metabolic efficiency. However, responses to B-vitamin supplementation are highly variable. The major challenge faced by studies on B-vitamin requirements of dairy cows is the very limited knowledge on dietary factors driving the fate of B vitamins in rumen. This knowledge is essential to identify the conditions under which the dairy cow could benefit from B-vitamin supplements. The present review aims to describe the present state of knowledge on B-vitamin requirements of dairy cows as well as some of the major problems that need to be overcome to progress in this research field.

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Effects of Biotin Supplementation on Peripartum Performance and Metabolites of Holstein Cows

Cited by 44 publications

References 28 publications

Net nutrient absorption and liver metabolism in lactating dairy cows fed supplemental dietary biotin

Net nutrient absorption and liver metabolism in lactating dairy cows fed supplemental dietary biotin

Impact of B-vitamin supply on major metabolic pathways of lactating dairy cows

New approaches, development, and improvement of methodologies for the assessment of B-vitamin requirements in dairy cows

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