Effects of binary mixtures on the life traits of Daphnia magna

Pavlaki, Maria D.; Pereira, Ricardo; Loureiro, Susana; Soares, Amadeu M.V.M.

doi:10.1016/j.ecoenv.2010.07.010

Cited by 83 publications

(69 citation statements)

References 50 publications

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“…Nevertheless, recent reports mention that environmental mean concentrations of nickel in relatively uncontaminated surface waters of six European regions ranged between 0.33 and 5.13 μg/L of dissolved Ni (Holmstrup et al, 2010;Spears, 1984). Values for nickel can vary from 69.3 to 110.7 μg/L during winter and from 41.0 to 60.7 μg/L during spring in the River Karoon, the biggest river in the South of Iran (Cempel and Nikel, 2006), while in seawater the dissolved nickel ranges from 0.1 to 0.5 μg/L (Bencko, 1983;Cempel and Nikel, 2006;Pavlaki et al, 2011;Takahashi and Hanazato, 2007).…”

Section: Introductionmentioning

confidence: 97%

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Changes of chemical chronic toxicity to Daphnia magna under different food regimes

Pavlaki

Ferreira

Soares

et al. 2014

Ecotoxicology and Environmental Safety

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Section: Introductionmentioning

confidence: 97%

“…Additionally, deviations from the conceptual model for synergism or antagonism patterns were also assessed. The single toxicity data used in this study were based on a previous study done by Pavlaki et al (2011).…”

Section: Introductionmentioning

confidence: 99%

Changes of chemical chronic toxicity to Daphnia magna under different food regimes

Pavlaki

Ferreira

Soares

et al. 2014

Ecotoxicology and Environmental Safety

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“…Over the last decades, several studies on mixture toxicology have compared two well-established models for the calculation of expected additive mixture effects (Drescher and Boedeker 1995;Payne et al 2000;Rajapakse et al 2001;Silva et al 2002;Pavlaki et al 2011): concentration addition (CA), first defined by Loewe and Muchnik (1926), and independent action (IA) as described by Bliss (1939). The concept of CA is based on the assumption that the mixture constituents have similar modes of action, which means that any component can be replaced partially or totally with another without changing the overall mixture effect.…”

Section: Introductionmentioning

confidence: 99%

The risky cocktail: what combination effects can we expect between ecstasy and other amphetamines?

2012

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The recreational and illicit use of amphetaminic designer compounds, specially 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy), is of concern worldwide. Such psychostimulating drugs are frequently present as complex mixtures in 'rave' pills, making concomitant polysubstance use a common trend. However, the understanding of possible combination effects with these substances is still scarce. The present study was aimed at predicting the cytotoxic effects of mixtures of four amphetaminic derivatives: MDMA, methamphetamine, 4-methylthioamphetamine and d-amphetamine in a human hepatoma cell line. Concentration-response curves for all single-mixture components were recorded by the MTT assay. Data obtained for individual agents were then used to compute the additivity expectations for mixtures of definite composition, using the pharmacological models of concentration addition (CA) and independent action. By comparing the predicted calculations with the experimentally observed effects, we concluded that CA accurately predicts the combination of amphetamines, which act together to generate additive effects over a large range of concentrations. Notably, we observed substantial mixture effects even when each drug was present at low concentrations, which individually produced unnoticeable effects. Nonetheless, for all tested mixtures, a small deviation from additivity was observed towards higher concentrations, particularly at high effect levels. A possible metabolic interaction, which could explain such deviation, was investigated, and it was observed that at higher mixture concentrations increased MDMA metabolism could be contributing to divergences from additivity. In conclusion, the present work clearly demonstrates that potentially harmful interactions among amphetaminic drugs are expected when these drugs are taken concomitantly.

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“…(b) Pesticide mixtures with similar modes of action Pavlaki et al(2010) looked at the effects of binary mixtures of two neonicotinoid insecticides imidacloprid and thiacloprid on various life stages of Daphnia magna. Data were tested against concentration addition and independent action models to determine which most appropriately described the data; unfortunately no actual data generated on mixtures during the course of this study was presented.…”

Section: Supporting Publications 2012:en-347 78mentioning

confidence: 99%

Repeated and multiple stress (exposure to pesticides) on aquatic organisms

Dennis

Tiede

Thompson

2012

EFSA Supporting Publications

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A systematic literature search identified publications relevant to repeated (94 papers) and mixture exposure (152 papers) of aquatic organisms. Limited data are available on pulsed exposure of pesticides and reports on repeated pulse or fluctuating exposures are even rarer. Although there has been recognition of the need for more realistic testing scenarios these lack a systematic approach. Among the reports on pesticide mixtures most of the plant studies evaluated interactions between mixtures of herbicides or fungicides / algicides. A small number of reports evaluated the effects on invertebrates of mixtures of pesticides with the same mode of action and these showed additive toxicity. More studies in invertebrates assessed interactions between pesticides with different modes of action including herbicide/ insecticide combinations some of which showed toxicity greater than additive. The majority of studies in fish have investigated the toxicity of insecticide mixtures. The toxicity of most combinations was at most additive, with a small number antagonistic. A small number of papers reported mixture effects of pesticides in amphibians; more than additive effects were observed with atrazine combinations. Simple models can be used to determine the additive toxicity of pesticide mixtures based on concentration addition or independent action. More complex models to determine the scale of synergy are species-and dose-dependent and rely on an understanding of the interactions involved. Further work is required to develop a greater understanding of the species, dose and time dependence of exposure to pesticide mixtures in which more complex interactions occur. In the interim, in the majority of cases the increase in toxicity is no greater than 3 fold when compared to additive, the deviation from additivity decreases with the increasing number of components in the mixture, and where no known interactions have been reported this may be an appropriate factor to include in risk assessments. KEY WORDSPulsed, mixtures, pesticides, aquatic organisms, synergism, additive effects DISCLAIMERThe present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors 1 Question No EFSA-Q-2011-00786. Repeated and Multiple Stress in Aquatic OrganismsSupporting publications 2012:EN-347 2The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the...

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Effects of binary mixtures on the life traits of Daphnia magna

Cited by 83 publications

References 50 publications

Changes of chemical chronic toxicity to Daphnia magna under different food regimes

Changes of chemical chronic toxicity to Daphnia magna under different food regimes

The risky cocktail: what combination effects can we expect between ecstasy and other amphetamines?

Repeated and multiple stress (exposure to pesticides) on aquatic organisms

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