Effects of basal insulin application on serum visfatin and adiponectin levels in type 2 diabetes

Abstract

The aim of this study was to investigate the effects of basal insulin application on the serum visfatin and adiponectin (APN) levels of patients with type 2 diabetes mellitus (T2DM). A total of 200 patients with T2DM, who were diagnosed in The Third People's Hospital of Jinan (glycosylated hemoglobin ≥7%), were randomly divided into treatment and control groups. The patients used only oral hypoglycemic drugs and had never received insulin therapy. In the treatment group, basal insulin was administered in combination with the original application of oral hypoglycemic drugs, whereas the control group maintained the original use of oral hypoglycemic drugs or took other oral hypoglycemic agents. The body mass index and fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, visfatin, APN and blood lipid levels of the patients were examined prior to the treatment and six months later. The drug and insulin doses in the treatment group were adjusted according to the patients' blood glucose, which allowed the fasting and postprandial blood glucose levels to attain the standards. The fasting and postprandial blood glucose levels in the control group also achieved the standards. It was found that the six-month application of basal insulin could significantly decrease the glycosylated hemoglobin and significantly increase the serum APN levels; the serum visfatin levels, however, remained unchanged. The immediate application of basal insulin could facilitate the attainment of glycosylated hemoglobin standards in T2DM and could increase the plasma APN levels, preventing diabetic vascular complications.

Prevalence and Risk Factors of Type 2 Diabetes and Prediabetes Among 53,288 Middle-Aged and Elderly Adults in China: A Cross-Sectional Study

“…In the current study, the incidence of prediabetes was only 3.7%, which was lower than that previously reported in China. 24–26 …”

“…In the current study, the incidence of prediabetes was only 3.7%, which was lower than that previously reported in China. [24][25][26] Since prediabetes was predominantly asymptomatic, people largely ignored routine blood glucose testing. This may be related to low awareness of prediabetes and insufficient attention to blood glucose in older adults.…”

“…This may be related to low awareness of prediabetes and insufficient attention to blood glucose in older adults. [24][25][26] This part of the population was not included in our study due to the lack of blood glucose data. However, we will address this group and report on the prevalence of T2DM and prediabetes in this sector of the population in future work.…”

Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus

“…A decreased resistin concentration by knocking out the resistin encoding gene or blocking resistin by antibody could protect against obesity-associated hyperglycemia, which is mainly due to recovering the response of the liver to insulin [ 35 ]. However, visfatin levels are not affected by the treatment of T2DM with basal insulin [ 36 ]. Although the difference is not significant between patients with and without T2DM in our study, resistin levels are increased in patients with overweight T2DM compared to those with non-overweight.…”

Gingival crevicular fluid levels of visfatin in patients with chronic periodontitis and polycystic ovary syndrome

“…Visfatin is an adipokine found in several tissues, such as bone marrow, liver, and muscles, and is usually secreted by the visceral fat tissue [1]. Visfatin has an insulin-like effect [2], and studies have shown that the serum visfatin levels in both obese and diabetic women were higher than that of healthy participants [3].…”