Effects of baicalin pre-treatment on pentylenetetrazole-induced seizures: Insights from zebrafish larvae locomotor behavior and neuronal calcium imaging

Cintra, Laís; Yanicostas, Constantin; Soussi-Yanicostas, Nadia; Vianna Maurer-Morelli, Claudia

doi:10.1016/j.yebeh.2024.109866

Epilepsy & Behavior

2024

DOI: 10.1016/j.yebeh.2024.109866

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Effects of baicalin pre-treatment on pentylenetetrazole-induced seizures: Insights from zebrafish larvae locomotor behavior and neuronal calcium imaging

Laís Cintra,

Constantin Yanicostas,

Nadia Soussi-Yanicostas

et al.

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2024

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The effects of baicalin in depression: preclinical evidence construction based on meta-analysis

Wang,

Ren,

Guo

et al. 2024

Front. Pharmacol.

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BackgroundDepression manifests as a mental disorder characterized by a low mood, suicidal tendencies, disturbances in sleep-wake cycles, psychomotor agitation, and pronounced feelings of hopelessness and anhedonia. Baicalin, a natural flavonoid compound, shows significant promise in alleviating depressive symptoms in animals. This study aims to assess the impact of baicalin on experimental models of depression.MethodsA systematic search of electronic databases was conducted using the search terms “baicalin” AND “depression” OR “depressed” OR “anti-depression”. Preclinical animal models representing experimental depression were included in the analysis. The risk of bias in the included studies was evaluated using the CAMARADES tools.ResultsBaicalin significantly increased sucrose preference test (SPT) [SMD= 21.31, 95%CI (16.32, 26.31), P < 0.00001]. mThe tail suspension test (TST) duration significantly decreased in the baicalin group compared to the model group [SMD = −39.3, 95%CI (−49.71, −28.89), P < 0.0001]. Furthermore, baicalin reduced immobility time in rats subjected to the forced swim test (FST) [SMD = −39.73, 95%CI (−48.77, −30.69) P < 0.0001]. Compared to the model group, baicalin treatment also significantly increased the frequency of crossings in the open field test (OFT) [SMD = 32.44, 95%CI (17.74, 47.13), P < 0.00001].ConclusionBaicalin significantly improves the manifestations of depressive symptoms. The effect of baicalin against depression is exerted through its anti-inflammatory actions, inhibition of oxidative stress, regulation of the HPA axis, and restoration of neuroplasticity. Future studies will be needed to further explore how these promising preclinical findings can be translated into clinical treatment for depression.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023472181.

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The effects of baicalin in depression: preclinical evidence construction based on meta-analysis

Wang,

Ren,

Guo

et al. 2024

Front. Pharmacol.

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Effects of baicalin pre-treatment on pentylenetetrazole-induced seizures: Insights from zebrafish larvae locomotor behavior and neuronal calcium imaging

Cited by 1 publication

References 37 publications

The effects of baicalin in depression: preclinical evidence construction based on meta-analysis

The effects of baicalin in depression: preclinical evidence construction based on meta-analysis

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