Biochemical Pharmacology volume 81, issue 9, P1106-1115 2011 DOI: 10.1016/j.bcp.2011.02.010 View full text
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Naoki Mori, Chie Ishikawa, Masachika Senba, Masashi Kimura, Yukio Okano

Abstract: We studied the effects of AZD1152, an Aurora B kinase inhibitor, on Burkitt's lymphoma (BL) and Hodgkin's lymphoma (HL) in human tissues and cell cultures and in a murine xenograft model of lymphoma. Aurora kinase A and B levels were assessed by RT-PCR and immunohistochemistry. They were aberrantly expressed in BL and HL cell lines, and in lymph nodes from patients with BL and HL. Next, activation of the Aurora B promoter was detected by reporter gene assays. The promoter activity of Aurora B kinase was high i…

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