Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery

Chello, Massimo; Patti, Giuseppe; Candura, Dario; Mastrobuoni, Stefano; Sciascio, Germano Di; Agrò, Felice Eugenio; Carassiti, Massimiliano; Covino, Elvio

doi:10.1097/01.ccm.0000201407.89977.ea

Cited by 195 publications

(183 citation statements)

References 34 publications

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“…The two previous meta-analyses 9 10 contained data on seven trials, [19][20][21][22][23][24][25] yielding a total of 3608 randomised patients and about 1050 person years of follow-up (0. 3 years per patient).…”

Section: Shorter Term Trialsmentioning

confidence: 99%

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Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials

Rahimi¹,

Emberson²,

McGale³

et al. 2011

BMJ

127

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Objective To examine whether statins can reduce the risk of atrial fibrillation. Design Meta-analysis of published and unpublished results from larger scale statin trials, with comparison of the findings against the published results from smaller scale or shorter duration studies. Data sources Medline, Embase, and Cochrane's CENTRAL up to October 2010. Unpublished data from longer term trials were obtained through contact with investigators.

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Section: Shorter Term Trialsmentioning

confidence: 99%

“…Tamayo et al 28 Chello et al 23 Ozaydin et al 24 Xia et al 30 Garcia-Fernandez et al 25 Dernellis et al 21 Song et al 26 Tveit et al 19 Ji et al 31 Mannacio …”

Section: Shorter Term Trials (Published Only)mentioning

confidence: 99%

Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials

Rahimi¹,

Emberson²,

McGale³

et al. 2011

BMJ

127

View full text Add to dashboard Cite

show abstract

“…Studies have shown that statins reduce neutrophil influx in the lung which might have a strong effect on attenuating the downstream inflammatory events, such as macrophage influx, lymphocyte activation and inhibition of cytokine release, in particular IL-8 that appears central to the neutrophil inflammation of the lung [67][68][69][70][71][72][73][74][75][76][77][80][81][82][83][84][85][86][87][88]. The inhibition of IL-6, IL-8 and GM-CSF expression by statins has been shown in cell cultures of human BEC [65,70].…”

Section: Statin Effects On Pulmonary Inflammation In Copdmentioning

confidence: 99%

Pharmacological actions of statins: potential utility in COPD

Young

Hopkins²,

Eaton³

2009

European Respiratory Review

122

184

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Chronic obstructive pulmonary disease (COPD) is characterised by minimally reversible airflow limitation and features of systemic inflammation. Current therapies for COPD have been shown to reduce symptoms and infective exacerbations and to improve quality of life. However, these drugs have little effect on the natural history of the disease (progressive decline in lung function and exercise tolerance) and do not improve mortality. The anti-inflammatory effects of statins on both pulmonary and systemic inflammation through inhibition of guanosine triphosphatase and nuclear factor-kB mediated activation of inflammatory and matrix remodelling pathways could have substantial benefits in patients with COPD due to the following. 1) Inhibition of cytokine production (tumour necrosis factor-a, interleukin (IL)-6 and IL-8) and neutrophil infiltration into the lung; 2) inhibition of the fibrotic activity in the lung leading to small airways fibrosis and irreversible airflow limitation; 3) antioxidant and anti-inflammatory (IL-6 mediated) effects on skeletal muscle; 4) reduced inflammatory response to pulmonary infection; and 5) inhibition of the development (or reversal) of epithelial-mesenchymal transition, a precursor event to lung cancer. This review examines the pleiotropic pharmacological action of statins which inhibit key inflammatory and remodelling pathways in COPD and concludes that statins have considerable potential as adjunct therapy in COPD.

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“…44 Finally, we found that preoperative statin use was associated with a 60% risk reduction in POAF incidence. The antiarrhythmic mechanism of statins can possibly be explained by their effects on inflammation 45,46,47,48 , antioxidant effects 49,50 , antiarrhythmic effects due to ion channel stabilization 51 , a role in extracellular matrix modulation 52 , an inhibition of synthesis of isoprenoids that are significant for the posttranslational modification of such signalling molecules as Rho, Rac, and Ras…”

Section: Discussionmentioning

confidence: 99%

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

Vukićević¹,

Putnik²,

Potpara³

2016

Srce i krvni sudovi

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Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery

Abstract: Pretreatment with atorvastatin significantly reduces cytokine release and neutrophil adhesion to the venous endothelium in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.

Cited by 195 publications

References 34 publications

Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials

Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials

Pharmacological actions of statins: potential utility in COPD

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

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