Effects of Aqueous Extracts of Cynanchum wilfordii in Rat Models for Postmenopausal Hot Flush

Lee, Gyuok; Choi, Chulyung; Jun, Woojin

doi:10.3746/pnf.2016.21.4.373

Cited by 10 publications

(7 citation statements)

References 31 publications

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“…Our previous study reported that C. wilfordii inhibited the elevation of skin temperature in OVX rats and did not affect plasma estrogen activity and uterine weight [35]. In this study, CPAE (Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz., and Angelica gigas Nakai extract) effectively relieved hot flash, a symptom of menopause, in OVX rat models.…”

Section: Discussionmentioning

confidence: 59%

Effects of Herbal Mixture Extract on Menopausal Hot Flashes and Pharmacokinetics in Ovariectomized Rat Models

Lee¹,

Kim²,

Kang³

et al. 2018

JFNR

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This study was conducted to evaluate the effects of Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz., and Angelica gigas Nakai extract (CPAE) on the reduction of tail skin temperature (TST) in ovariectomized (OVX) rats. To evaluate TST reduction in ovariectomized rats, 125, 250, and 1000 mg/kg CPAE was administered to rats for 1 week. The measurement of TST after the induction of artificial stress revealed a significant temperature reduction effect in the CPAE administration group (p<0.05). The TST induced by the injection of yohimbine, to induce hot flashes, was found to decrease as the administered dose of CPAE increased from 10 min to 20min (125 and 250 mg/kg/day, p<0.05; 1000 mg/kg/day, p<0.01). In addition, in a drug interaction test between tamoxifen, an anti-estrogen drug, and CPAE, no significant difference was found between the pharmacokinetic (PK) profiles after the administration of tamoxifen only and the combination of tamoxifen and CPAE. We also found that CPAE did not affect CYP2d4 and CYP3a2, which affect tamoxifen metabolism, in a subsequent experiment on liver tissues extracted during the drug interaction test. In this study, we found that CPAE inhibited temperature increase on the tail skin of OVX rats, and therefore is effective in the improvement of hot flashes. CPAE may be potentially used for the improvement of hot flashes induced by the administration of tamoxifen.

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Section: Discussionmentioning

confidence: 59%

Effects of Herbal Mixture Extract on Menopausal Hot Flashes and Pharmacokinetics in Ovariectomized Rat Models

Lee¹,

Kim²,

Kang³

et al. 2018

JFNR

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“…For example, caudatin, 2,4-dihydroxyacetophenone, 2,5-dihydroxyacetophenone, 4-hydroxyacetophenone, and baishouwubenzophenone were all isolated from CA , CB and CW , indicating there were close relationships among them [ 24 , 25 , 26 , 27 , 28 , 29 ]. C 21 -steroids (deacylmetaplexigenin, rostratamine, wilfoside C1G, cynanauriculoside E, kidjoranin, cyanoauriculoside A, wilfoside M1N), acetophenones (cynandione A–B, cynandione E), and other compounds (leucanthemitol, suceinie acid, sucrose, methyleugenol) were all obtained from CA and CW , which might strengthen the relationship between them [ 5 , 27 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. Bungeiside C, bungeiside D and 2- O -β-laminaribiosyl-4-hydroxyacetophenone were obtained from CB and CW , thereby revealing their close relationship between them [ 42 , 43 ].…”

Section: Botanymentioning

confidence: 99%

Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects

et al. 2021

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Cynanchum auriculatum Royle ex Wight. (CA), Cynanchum bungei Decne. (CB) and Cynanchum wilfordii (Maxim.) Hemsl. (CW) are three close species belonging to the Asclepiadaceous family, and their dry roots as the bioactive part have been revealed to exhibit anti-tumor, neuroprotection, organ protection, reducing liver lipid and blood lipid, immunomodulatory, anti-inflammatory, and other activities. Until 2021, phytochemistry investigations have uncovered 232 compounds isolated from three species, which could be classified into C21-steroids, acetophenones, terpenoids, and alkaloids. In this review, the morphology characteristics, species identification, and the relationship of botany, extraction, and the separation of chemical constituents, along with the molecular mechanism and pharmacokinetics of bioactive constituents of three species, are summarized for the first time, and their phytochemistry, pharmacology, and clinical safety are also updated. Moreover, the direction and limitation of current research on three species is also discussed.

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“…Ten-week-old female rats were ovariectomized (OVX) and treated with the aqueous extract of CWW for 1 week. The administration of CWW (200 mg/kg/d for 7 days, per os) significantly improves skin temperature increase in OVX rats [ 119 ]. Moreover, the aqueous extract of CWW inhibits the development of benign prostatic hyperplasia (BPH) in a testosterone-induced BPH rat model [ 120 ].…”

Section: Pharmacologymentioning

confidence: 99%

Ethnobotany, Phytochemistry and Pharmacological Effects of Plants in Genus Cynanchum Linn. (Asclepiadaceae)

et al. 2018

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Genus Cynanchum L. belongs to the family Asclepiadaceae, which comprise more than 200 species distributed worldwide. In Chinese medical practice, numerous drugs (such as tablets and powders) containing different parts of plants of this genus are used to treat snake bites, bruises, osteoblasts, rheumatoid arthritis and tumors. A search for original articles published on the cynanchum genus was performed by using several resources, including Flora of China Official Website and various scientific databases, such as PubMed, SciFinder, the Web of Science, Science Direct, and China Knowledge Resource Integrated (CNKI). Advances in the botanical, ethnomedicinal, phytochemical, and pharmacological studies of this genus are reviewed in this paper. Results showed that more than 440 compounds, including C21 steroids, steroidal saponins, alkaloids, flavonoids and terpene, have been isolated and identified from Cynanchum plants up to now. In vivo and in vitro studies have shown that plants possess an array of biological activities, including anti-tumor, neuroprotective and anti-fungal effects. Popular traditional prescription of Cynanchum sp. was also summed up in this paper. However, many Cynanchum species have received little or no attention. Moreover, few reports on the clinical use and toxic effects of Cynanchum sp. are available. Further attention should be focused on the study of these species to gather information on their respective toxicology data and relevant quality-control measures and clinical value of the crude extracts, active compounds, and bioactive metabolites from this genus. Further research on Cynanchum sp. should be conducted, and bioactivity-guided isolation strategies should be emphasized. In addition, systematic studies of the chemical composition of plants should be enhanced.

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Effects of Aqueous Extracts of Cynanchum wilfordii in Rat Models for Postmenopausal Hot Flush

Cited by 10 publications

References 31 publications

Effects of Herbal Mixture Extract on Menopausal Hot Flashes and Pharmacokinetics in Ovariectomized Rat Models

Effects of Herbal Mixture Extract on Menopausal Hot Flashes and Pharmacokinetics in Ovariectomized Rat Models

Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects

Ethnobotany, Phytochemistry and Pharmacological Effects of Plants in Genus Cynanchum Linn. (Asclepiadaceae)

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