Effects of AP5 infusion into the lateral ventricle on the activities and hippocampal electrical patterns of sleep episodes in rats

Melik, Enver; Babar, Emine; Güven, Mustafa

doi:10.1016/j.physbeh.2005.11.008

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Our data show that once stabilized, the induced SPWs are sensitive to blockade by the AMPA glutamate receptor antagonist NBQX but not by the NMDA receptor antagonist AP5 or MK-801. Such a differential sensitivity to glutamate receptor antagonists is in keeping with the pharmacological features of rat hippocampal EEG SPWs (Leung and Shen, 2004;Melik et al, 2006) and the spontaneous in vitro SPWs (Wu et al, 2005b). Collectively, these data suggest that hippocampal SPWs are dependent upon the AMPA glutamatergic activity for their expression.…”

Section: Role Of Nmda Receptors In Initiation Of In Vitro Spwssupporting

confidence: 65%

“…Our observed in vitro SPWs share some common features with the rat hippocampal EEG SPWs regarding regional initiation, pharmacological responses, and cellular correlates (Buzsáki, 1986;Suzuki and Smith, 1987;Ylinen et al, 1995;Csicsvari et al, 2000;Leung and Shen, 2004;Melik et al, 2006). However, the in vitro SPWs are greater in amplitudes and correlate with stronger excitatory activities in individual CA3 pyramidal neurons when compared with the EEG SPWs.…”

Section: Functional Significance Of In Vitro Spwssupporting

confidence: 60%

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Adenosine as an endogenous regulating factor of hippocampal sharp waves

Wong

et al. 2008

Hippocampus

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The rodent hippocampus exhibits population activities called sharp waves (SPWs) during slow wave sleep and wake immobility. SPWs are important for hippocampal-cortical communication and memory consolidation, and abnormal sharp wave-ripple complexes are closely related to epileptic seizures. Although the SPWs are known to arise from the CA3 circuit, the local mechanisms underlying their generation are not fully understood. We hypothesize that endogenous adenosine is a local regulator of hippocampal SPWs. We tested this hypothesis in thick mouse hippocampal slices that encompass a relatively large hippocampal circuit and have a high propensity of generating spontaneous in vitro SPWs. We found that application of adenosine A1 receptor antagonists induced in vitro SPWs and that such induction was sensitive to blockade by NMDA receptor antagonists. By contrast, an increase in endogenous adenosine via pharmacological inhibition of adenosine transporters or adenosine degrading enzymes suppressed spontaneous in vitro SPWs. We thus suggest that the initiation and incidence of sharp wave-like population events are under tight control by the activity of endogenously stimulated A1 receptors.

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Section: Role Of Nmda Receptors In Initiation Of In Vitro Spwssupporting

confidence: 65%

Section: Functional Significance Of In Vitro Spwssupporting

confidence: 60%

Adenosine as an endogenous regulating factor of hippocampal sharp waves

Wong

et al. 2008

Hippocampus

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“…We use the thick mouse hippocampal slices as an in vitro model system because these slices encompass a relatively intact circuit and have a high propensity to generate spontaneous in vitro SPWs. We have previously shown (Wu et al, 2005a) that the in vitro SPWs share some common features with rat hippocampal EEG SPWs regarding CA3 initiation, correlation with neuronal discharges and suppression by AMPA but not NMDA glutamate receptor antagonists (Ylinen et al, 1995;Csicsvari et al, 2000;Leung & Shen, 2004;Melik et al, 2006). However, the in vitro SPWs are greater in amplitude and associated with stronger excitatory activities in individual CA3 pyramidal neurons as compared to rat EEG SPWs.…”

Section: Physiological or Pathophysiological Relevance Of In Vitro Spwsmentioning

confidence: 87%

Cellular mechanisms of cobalt‐induced hippocampal epileptiform discharges

Hsiang

et al. 2009

Epilepsia

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SUMMARYPurpose: To explore the cellular mechanisms of cobalt-induced epileptiform discharges in mouse hippocampal slices. Methods: Hippocampal slices were prepared from adult mice and briefly exposed to a CoCl 2 -containing external solution. Population and single cell activities were examined via extracellular and whole-cell patch recordings. Results: Brief cobalt exposure induced spontaneous, ictal-like discharges originating from the CA3 area. These discharges were suppressed by anticonvulsants, gap junction blockers, or by raising extracellular Ca 2+ , but their generation was not associated with overall hyperexcitability or impairment in GABAergic inhibition in the CA3 circuit. Electroencephalographic ictal discharges of similar waveforms were observed in behaving rats following intrahippocampal cobalt infusion. Discussion: Mechanisms involving activity-dependent facilitation of gap junctional communication may play a major role in cobalt-induced epileptiform discharges.

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Effects of REM deprivation and an NMDA agonist on the extinction of conditioned fear

Silvestri

Root

2008

Physiology & Behavior

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Effects of AP5 infusion into the lateral ventricle on the activities and hippocampal electrical patterns of sleep episodes in rats

Cited by 4 publications

References 37 publications

Adenosine as an endogenous regulating factor of hippocampal sharp waves

Adenosine as an endogenous regulating factor of hippocampal sharp waves

Cellular mechanisms of cobalt‐induced hippocampal epileptiform discharges

Effects of REM deprivation and an NMDA agonist on the extinction of conditioned fear

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