Effects of Ankaferd on Anastomotic Healing of Colon

Abstract

ABS may support anastomotic healing in septic conditions. Topical ABS application controlling the mucosal bleeding at the cut ends of the colon may also improve the anastomotic wound healing by means of increasing mechanical strength and positively affecting angiogenesis. Further studies shall focus on the clinical importance of those findings.

Effect of Ankaferd blood stopper® on tendon healing: an experimental study in a rat model of Achilles tendon injury

“…Our study showed that ABS decreases collagen bundle organization, which is one of the indicators of the healing process. However, Cancan et al [7] showed that topical ABS improves collagen production, and may support anastomotic healing in septic conditions in rats. These opposite results may be secondary to the different aseptic surgical and aseptic healing conditions that exist between the studies.…”

“…In another study which was performed to evaluate radiologic results and serum changes of oxidative stress markers during fracture healing process with and without ABS application to bone fracture, it was shown that ABS was ineffective on fracture healing in early healing period except for bleeding control. [33] Cancan et al [7] studied the effects of ABS on colonic anastomosis. They showed that ABS may support anastomotic healing in septic conditions.…”

“…[7] Theoretically, anti-inflammatory effect of ABS may inhibit collagenolysis. According to our study, ABS has a significantly negative effect on collagen bundle organization and the total Bonar score.…”

“…[3,7] Ankaferd Blood Stopper ® is a standardized extract from the following plants: Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, Urtica dioica, and Thymus vulgaris in a weight ratio of 9: 8: 7: 6: 5, respectively. [19,20] Alpinia officinarum has an inhibitory effect on nitric oxide production by lipopolysaccharide-activated mouse peritoneal macrophages.…”

“…[5] In the late 2000s, Turkish physicians standardized ABS as a modern hemostatic agent by making known its pharmacodynamics and molecular mechanisms. [3,[5][6][7] Ankaferd Blood Stopper ® has been shown to have hemostatic and regenerative proliferation effects in studies conducted in vivo and in vitro. [8,9] Ankaferd Blood Stopper ® stimulates the construction of a protein network with an alternative pathway via affecting cellular mechanisms.…”