2004
DOI: 10.1056/nejmoa031766
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Abstract: In subjects with low HDL cholesterol levels, CETP inhibition with torcetrapib markedly increased HDL cholesterol levels and also decreased LDL cholesterol levels, both when administered as monotherapy and when administered in combination with a statin.

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Cited by 714 publications
(440 citation statements)
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“…Similar comprehensive data were collected for torcetrapib, an inhibitor of cholesteryl ester transfer protein (CETP) that elevates HDL-C levels 115,116 . Based on pre-clinical data, a beneficial effect on plaque regression was postulated.…”
Section: Correlation Between Ivus and Cimtmentioning
confidence: 84%
“…Similar comprehensive data were collected for torcetrapib, an inhibitor of cholesteryl ester transfer protein (CETP) that elevates HDL-C levels 115,116 . Based on pre-clinical data, a beneficial effect on plaque regression was postulated.…”
Section: Correlation Between Ivus and Cimtmentioning
confidence: 84%
“…There was no significant difference in frequency of CETP I405V in patients when compared with controls. This genotype is shown to be associated with a reduction in CETP activity, and increased level of HDL cholesterol [20][21][22][23].…”
Section: Discussionmentioning
confidence: 99%
“…A complex dose effect for some of the statins on HDL levels has been shown in previous studies, and hence dose adjustments (in either direction) may be a strategy to consider when aberrations in HDL levels are noted (39). Additionally, the use of strategies, both pharmacologic and nonpharmacologic that may help in increasing HDL-levels, may help in making steroidminimization even more attractive than it presently is (40).…”
Section: Discussionmentioning
confidence: 88%