Effects of an allatostatin and a myosuppressin on midgut carbohydrate enzyme activity in the cockroach Diploptera punctata

Fusé, Megumi; Zhang, J.R; Partridge, Elizabeth A.; Nachman, Ronald J.; Orchard, Ian; Bendena, William G.; Tobe, Stephen S.

doi:10.1016/s0196-9781(99)00133-3

Cited by 114 publications

(65 citation statements)

References 39 publications

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“…This myoinhibitory property of FGLa/ASTs is well documented in a number of insect species. For example, FGLa/ASTs inhibit peristaltic contractions of the foregut in Calliphora vomitoria, S. gregaria and Leucophaea maderae (Duve and Thorpe, 1994;Zilberstein et al, 2004;Duve et al, 1995), proctolin-induced contractions of the midgut in Diploptera punctata (Fusé et al, 1999), and spontaneous and proctolin-induced contractions of the hindgut in D. punctata and S. gregaria (Lange et al, 1993;Lange et al, 1995;Veelaert et al, 1996). Other myoinhibitory effects of FGLa/ASTs include inhibition of spontaneous oviducal contractions in S. gregaria (Veelaert et al, 1996) and modulation of the cardiac rhythm in Blattella germanica (Vilaplana et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…The allatostatins and allatotropins have opposing effects on gut contraction. The FGLa/ASTs inhibit spontaneous and proctolin-induced gut contraction (Lange et al, 1993;Lange et al, 1995;Duve et al, 1995;Sarkar et al, 2003;Fusé et al, 1999). The MIPs (also known as B-type ASTs) were originally named because of their inhibition of hindgut and oviducal contractions in the locust (Schoofs et al, 1991) and members of this family inhibit gut contraction in other insect species, including cockroaches (Predel et al, 2001) (see Audsley and Weaver, 2009).…”

Section: Introductionmentioning

confidence: 99%

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The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson

Rodriguez

Lange

2012

Journal of Experimental Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson

Rodriguez

Lange

2012

Journal of Experimental Biology

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“…Allatostatins are a family of neuropeptides that share a conserved C-terminal sequence -Tyr/PheXaaPheGlyLeu-NH 2 and are widespread throughout the invertebrate lineage (9,10). In insects, allatostatins regulate numerous physiological functions, including inhibition of juvenile hormone biosynthesis (11,12), inhibition of muscle contraction (13), myoendocrine regulation (14,15), neuromodulation (16), and regulation of enzymatic activities (17) and ecdysis (18). Similarly, mammalian galanin modulates a wide variety of processes that range from neurotransmission, nociception, feeding and metabolism, energy and osmotic homeostasis and learning and memory (19).…”

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confidence: 99%

A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues

Bendena

Boudreau

Papanicolaou

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Movement inCaenorhabditis elegans is the result of sensory cues creating stimulatory and inhibitory output from sensory neurons. Four interneurons (AIA, AIB, AIY, and AIZ) are the primary recipients of this information that is further processed en route to motor neurons and muscle contraction. C. elegans has >1,000 G proteincoupled receptors (GPCRs), and their contribution to sensory-based movement is largely undefined. We show that an allatostatin/ galanin-like GPCR (NPR-9) is found exclusively in the paired AIB interneuron. AIB interneurons are associated with local search/ pivoting behavior. npr-9 mutants display an increased local search/ pivoting that impairs their ability to roam and travel long distances on food. With impaired roaming behavior on food npr-9 mutants accumulate more intestinal fat as compared with wild type. Overexpression of NPR-9 resulted in a gain-of-function phenotype that exhibits enhanced forward movement with lost pivoting behavior off food. As such the animal travels a great distance off food, creating arcs to return to food. These findings indicate that NPR-9 has inhibitory effects on the AIB interneuron to regulate foraging behavior, which, in turn, may affect metabolic rate and lipid storage.neuropeptide receptor ͉ nerve transmission ͉ foraging ͉ glutamate receptor ͉ interneuron A major challenge in neurobiology is to understand the control of behavior at the molecular level. Neuropeptides and their receptors offer promising candidates for the regulation of various behaviors and changes in physiology. The Caenorhabditis elegans genome sequence has allowed the identification of 109 putative neuropeptide genes encoding precursors that may be processed to Ϸ250 neuropeptides (1-3). These neuropeptides are grouped into three families: FMRFamide-related peptides (f lp), insulin-like peptides (ins), and neuropeptide-like-peptides (nlps). C. elegans expresses Ͼ1,000 orphan G protein-coupled receptors (GPCRs). More than 50 GPCRs resemble known receptors for known neuropeptide families based on phylogenetic comparisons with known vertebrate GPCRs (4). Of these GPCRs, based on sequence identity, C. elegans gene ZK455.3 expresses an nlp receptor, NPR-9, that is most similar to insect allatostatin/ mammalian galanin receptors (5-8). Allatostatins are a family of neuropeptides that share a conserved C-terminal sequence -Tyr/PheXaaPheGlyLeu-NH 2 and are widespread throughout the invertebrate lineage (9, 10). In insects, allatostatins regulate numerous physiological functions, including inhibition of juvenile hormone biosynthesis (11, 12), inhibition of muscle contraction (13), myoendocrine regulation (14, 15), neuromodulation (16), and regulation of enzymatic activities (17) and ecdysis (18). Similarly, mammalian galanin modulates a wide variety of processes that range from neurotransmission, nociception, feeding and metabolism, energy and osmotic homeostasis and learning and memory (19). We report that NPR-9 is uniquely localized in interneuron AIB to negatively regulate a variety of inputs th...

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“…There is a growing body of evidence indicating that endocrine peptides, such as AST, AKH, CCAP and FLRFamides, and biogenic amines are part of complex regulatory loops involved in coordinating key aspects in insect digestive processes, including enzyme secretion, muscle contraction, ion transport and foraging behavior [39,42,46,62,65,97]. However, we still need a better understanding of the processes involved.…”

Section: Future Directionsmentioning

confidence: 99%

“…SchistoFLRF-amide also influences the activity of digestive enzymes; a-amylase activity increased in both the lumen and tissue midguts extracts incubated with this peptide, as did a-glucosidase activity in the lumen contents [46]. Similarly, FaRPs appear to modulate the release of invertase, which catalyzes the breakdown of sucrose to fructose and glucose, in midguts of the Pacific beetle cockroach, Diploptera punctata [39]. Furthermore, myosuppressins, a sub-group of FLRF-amides, regulate food movement into the midgut the site of digestion and nutrient absorption [62,65] through inhibition of visceral muscle contractions in different parts of the gut [65].…”

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confidence: 94%

The role of neuropeptides in caterpillar nutritional ecology

2007

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Plant diet strongly impacts the fitness of insect herbivores. Immediately, we think of plant defensive compounds that may act as feeding deterrents or toxins. We are, probably, less aware that plants also influence insect growth and fecundity through their nutritional quality. However, most herbivores respond to their environment and select the diet which optimizes their growth and development. [...] Understanding the effects of diet on the insect herbivore is essential for the rational design and implementation of sustainable pest management practices

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Effects of an allatostatin and a myosuppressin on midgut carbohydrate enzyme activity in the cockroach Diploptera punctata

Cited by 114 publications

References 39 publications

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues

The role of neuropeptides in caterpillar nutritional ecology

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