Effects of Amrinone in an Experimental Model of Hepatic Ischemia-Reperfusion Injury

Küçük, Can; Akçan, Alper; Akyýldýz, Hizi; Akgün, Hülya; Muhtaroğlu, Sebahattin; Sözüer, Erdoğan

doi:10.1016/j.jss.2008.02.008

Cited by 15 publications

(12 citation statements)

References 45 publications

(52 reference statements)

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“…The implicated factors include free oxygen radicals, leukocyte migration and activation, microcirculatory abnormalities, sinusoidal endothelial cell damage, activation of the coagulation cascade, Kupffer cell activation due to the release of inflammatory cytokines, and proteolytic enzymes (Kucuk et al 2009). Due to the large amount of oxygen influx during reperfusion, xanthine oxidase catalyzes the conversion of hypoxanthine to xanthine, and simultaneously generates superoxide (Iwamoto et al 2002).…”

Section: Discussionmentioning

confidence: 99%

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Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

et al. 2014

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There is little information about the hepatoprotective effects of gallic acid against ischemiareperfusion (I/R) damage. Animals were subjected to I/R. Gallic acid at doses of 50 and 100 mg/kg body weight (bw) were injected as a single dose prior to ischemia. Liver tissue homogenates were used for the measurement of malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GPx) levels. At the same time alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were assayed in serum samples and compared statistically. While the ALT, AST, LDH activities and MDA levels were significantly increased, CAT and GPx activities significantly decreased in only I/Rinduced control rats compared to normal control rats (P \ 0.05). Treatment with gallic acid at a dose of 100 mg/kg bw significantly decreased the ALT, AST, LDH activities and MDA levels, and markedly increased activities of CAT and GPx in tissue homogenates compared to I/R-induced rats with no treatment group (P \ 0.05). In oxidative stress generated by hepatic ischemia-reperfusion, gallic acid contributes partially an alteration in the delicate balance between the scavenging capacity of antioxidant defense systems and free radicals in favour of the antioxidant defense systems in the body.

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Section: Discussionmentioning

confidence: 99%

“…In various studies, it has been shown that the serum concentrations of these enzymes increase in proportion with the duration of ischemia (Kucuk et al 2009). In the present study, the serum AST, ALT and LDH levels in the I/R-100 group were significantly lower than in the I/R-C and I/R ?…”

Section: Discussionmentioning

confidence: 99%

Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

et al. 2014

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“…Pre-ischemic administration of phosphodiesterase III inhibitors in different species (dogs, rabbits, rats) and organs (heart, liver) protects against ischemiareperfusion injury (Kobayashi et al, 2002;Kucuk et al, 2009). Milrinone or olprinone, when administered before ischemia-reperfusion, was cardioprotective and reduced infarct size in dogs (Setoyama et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological preconditioning by milrinone: Memory preserving and neuroprotective effect in ischemia-reperfusion injury in mice

2010

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We tested the neuroprotective effect of milrinone, a phosphodiesterase III inhibitor, in pharmacological preconditioning. Bilateral carotid artery occlusion for 12 min followed by reperfusion for 24 h produced ischemia-reperfusion (I/R) cerebral injury in male Swiss albino mice. Cerebral infarct size was measured using triphenyltetrazolium chloride staining. Memory was assessed using the Morris water maze test, and motor coordination was evaluated using the inclined beam walking test, rota-rod test, and lateral push test. Milrinone (50 microg/kg & 100 microg/kg i.v.) was administered 24 h before surgery in a separate group of animals to induce pharmacological preconditioning. I/R increased cerebral infarct size and impaired memory and motor coordination. Milrinone treatment significantly decreased cerebral infarct size and reversed I/R-induced impairments in memory and motor coordination. This neuroprotective effect was blocked by ruthenium red (3 mg/kg, s.c.), an intracellular ryanodine receptor blocker. These findings indicate that milrinone preconditioning exerts a marked neuroprotective effect on the ischemic brain, putatively due to increased intracellular calcium levels activating calcium-sensitive signal transduction cascades.

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“…Free oxygen radicals, leukocyte migration and activation, microcirculatory abnormalities, sinusoidal endothelial cell damage, activation of the coagulation cascade, Kupffer cell activation due to release of infl ammatory cytokines and proteolytic enzymes are the related factors for the damages (2)(3)(4). Several agents targeting these factors have been studied recently (2)(3)(4)(5)(6)(7). Oxygen free radicals, produced on reperfusion play a triggering and critical role in the injury caused by ischemia-reperfusion (IR).…”

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confidence: 99%

The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats

Aydın¹,

Şakrak²,

Tu³

et al. 2014

BLL

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Abstract:Background: Ischemia-reperfusion injury (IR) is associated with a high morbidity and mortality. Several agents have been used to protect the liver after IR. We aimed to investigated the effects of the Hypericum perforatum on IR of the liver. Methods: A total of 62 wistar-albino male rats in 4 groups were used. Sham group (n: 8). Control group (IR, n: 18) was underwent partially liver ischemia and reperfusion (IR). Carboxymethyl cellulose group (CMC n: 18) was given 0.5 % carboxymethyl cellulose before IR for a week. Hypericum perforatum group (HP, n:18) was given 0.5 % carboxymethyl cellulose supplemental the extract of Hypericum perforatum before IR for a week. Blood and liver samples were obtained before ischemia, and 1, 2, 4 hours after the reperfusion. AST, ALT, LDH, TNF-α, IL-6, MDA and advanced oxidation protein products(AOPP) levels were determined in blood samples. Histological evaluation and tissue MDA, AOPP levels were determined. Results: Blood levels of ALT, TNF-α, IL-6 and MDA were signifi cantly low in HP group compared with IR and CMC groups (p < 0.05). There was no difference between the liver injury scrores of IR and CMC groups (p > 0.05). Conslusion: These results indicate that H. perforatum can protect the liver against IR. As antioxidative agent, Hypericum perforatum has both local and systemic protective effects in ischemia reperfusion injury (Tab. 1, Fig. 4, Ref. 31). Text in PDF www.elis.sk.

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Effects of Amrinone in an Experimental Model of Hepatic Ischemia-Reperfusion Injury

Cited by 15 publications

References 45 publications

Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats

Pharmacological preconditioning by milrinone: Memory preserving and neuroprotective effect in ischemia-reperfusion injury in mice

The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats

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