Effects of amiloride on renal lithium handling in ascitic cirrhotics with avid sodium retention

Angeli, Paolo; Bei, E. De; Pria, M. Dalla; Caregaro, L.; Ceolotto, Giulio; Albino, G.; Gatta, Angelo

doi:10.1016/0168-8278(91)91332-b

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Mechanisms Of Water Retention and Dilutional Hyponatremia In1

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1998

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“…Lithium clearance, which estimates distal fluid delivery, is reduced in patients with cirrhosis and ascites. 97 It has been proposed that decreased distal sodium delivery is responsible for the impaired escape from aldosterone and atrial natriuretic peptide (ANP) resistance in decompensated cirrhosis. 98 Recently, a group of 12 cirrhotic patients with ascites, resistant to the natriuretic effect of ANP, was studied during the infusion of ANP plus mannitol to increase distal fluid and sodium delivery.…”

Section: Mechanisms Of Water Retention and Dilutional Hyponatremia Inmentioning

confidence: 99%