2008
DOI: 10.1161/hypertensionaha.107.108845
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Abstract: Abstract-The aim of this study was to explore the effects of the renin inhibitor aliskiren in streptozotocin-diabetic TG(mRen-2)27 rats. Furthermore, we investigated in vitro the effect of aliskiren on the interactions between renin and the (pro)renin receptor and between aliskiren and prorenin. Aliskiren distributed extensively to the kidneys of normotensive (non)diabetic rats, localizing in the glomeruli and vessel walls after 2 hours exposure. In diabetic TG(mRen-2)27 rats, aliskiren (10 or 30 mg/kg per day… Show more

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Cited by 267 publications
(303 citation statements)
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“…In another study with diabetic mRen-2 rats in which BP was monitored continuously by telemetry, aliskiren at 10, 30 and 60 mg kg -1 per day dose dependently reversed existing hypertension and prevented the development of albuminuria over the 10 weeks study. 87 At the end of this study, renal cortical gene expression of collagen I and the pro-fibrotic growth factor, transforming growth factor-b (TGF-b), in the mRen-2 rats were significantly reduced in the aliskiren vs. the vehicle group.…”
Section: Testing Aliskiren In Animal Modelsmentioning
confidence: 90%
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“…In another study with diabetic mRen-2 rats in which BP was monitored continuously by telemetry, aliskiren at 10, 30 and 60 mg kg -1 per day dose dependently reversed existing hypertension and prevented the development of albuminuria over the 10 weeks study. 87 At the end of this study, renal cortical gene expression of collagen I and the pro-fibrotic growth factor, transforming growth factor-b (TGF-b), in the mRen-2 rats were significantly reduced in the aliskiren vs. the vehicle group.…”
Section: Testing Aliskiren In Animal Modelsmentioning
confidence: 90%
“…65 and mouse. 87 The anti-inflammatory effect of aliskiren observed in the kidneys of dTGR 71 and eNOS À/À 75 mice is not a renal-specific effect. Recently, Ino and coworkers 76 reported that at a non-BP-lowering dose, aliskiren reduced leukocyte adhesion in a murine vascular injury model.…”
Section: Testing Aliskiren In Animal Modelsmentioning
confidence: 98%
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