Effects of Aging in Dry Eye

Paiva, Cintia S. de

doi:10.1097/iio.0000000000000170

Cited by 88 publications

(65 citation statements)

References 181 publications

(147 reference statements)

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“…Given that tear and protein secretion are energy-requiring active procedures, the LGs appear to be highly susceptible to pathological aging. Emerging evidence suggests that the LGs undergo inflammation, atrophy, fibrosis, or ductal cell proliferation with aging in humans, as well as rodents [6,[9][10][11]. Aging impairs the LGs by altering multiple mechanisms, such as neuroendocrine, immunological, apoptotic, protein secretion, and oxidative stress pathways [11].…”

Section: Discussionmentioning

confidence: 99%

“…Data are presented as means ± standard error. 6, and 3 for 8W-, 1Y-, and 2Y-old mice, respectively). Ns, not significant; *p < 0.05 and ****p < 0.0001.…”

Section: Ded Was Established In Aged C57bl/6 Male Micementioning

confidence: 96%

“…The aging-dependent changes in the ocular surface with DED are related to biological changes in the lacrimal glands (LGs) and meibomian glands (MGs). Although the pathogenesis of aging-associated DED has not yet been fully understood, recent studies have shown that autoimmune changes or oxidative stress in the LGs and acinar cell atrophies in the MGs occur with aging [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model

Yoon

Ryu

Hwang

et al. 2020

IJMS

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It is not known how biological changes in the lacrimal (LGs) and meibomian (MGs) glands contribute to dry eye disease (DED) in a time-dependent manner. In this study, we investigated time-sequenced changes in the inflammation, oxidative stress, and senescence of stem cells in both glands of an aging-related DED mouse model. Eight-week (8W)-, one-year (1Y)-, and two-year (2Y)-old C57BL/6 male mice were used. MG areas of the upper and lower eyelids were analyzed by transillumination meibography imaging. The number of CD45+, 8-OHdG+, Ki-67+, and BrdU+ cells was compared in both glands. Increased corneal staining and decreased tear secretion were observed in aged mice. The MG dropout area increased with aging, and the age-adjusted MG area in lower lids was negatively correlated with the National Eye Institute (NEI) score. Increased CD4+ interferon (IFN)-γ+ cells in LGs were found in both aged mice. An increase in 8-OHdG+ cells in both glands was evident in 2Y-old mice. Reduced Ki-67+ cells, but no change in CD45+ cells, was observed in the MGs of 1Y-old mice. Increased BrdU+ cells were observed in the LGs of aged mice. This suggests that age-dependent DED in C57BL/6 mice is related to inflammation of the LGs, the development of MG atrophy, and oxidative stress in both glands.

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Section: Discussionmentioning

confidence: 99%

“…Data are presented as means ± standard error. 6, and 3 for 8W-, 1Y-, and 2Y-old mice, respectively). Ns, not significant; *p < 0.05 and ****p < 0.0001.…”

Section: Ded Was Established In Aged C57bl/6 Male Micementioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model

Yoon

Ryu

Hwang

et al. 2020

IJMS

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“…[47][48][49] While there are large scale studies that failed to show a significant difference in success rates between presbyopic and non-presbyopic contact lens wearers, 16 setting realistic expectations with "real world" testing of multifocal contact lenses and using the latest multifocal designs and materials may prove to be uniquely successful when fitting presbyopic patients. Unfortunately, conditions such as dry eye are more common in this group of patients, 50 which is an additional hurdle that may promote contact lens dropout in presbyopic patients. 51 Again, as described above, early treatment may promote additional years of comfortable contact lens use.…”

Section: Combatting Contact Lens Dropoutmentioning

confidence: 99%

<p>A Review of Contact Lens Dropout</p>

Pucker¹,

Tichenor

2020

OPTO

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Purpose: Contact lens (CL) dropout is likely a major factor contributing to the near stagnant growth in the CL market. The purpose of this review is to summarize the current state of knowledge related to the frequency of CL dropout and the factors associated with it. Methods: PubMed.gov was searched on or before March 22, 2020, with the terms "contact lens" with "dropout" or "cessation" or "disruption" or "discomfort". Pertinent articles were collected. The references from these articles were likewise searched to identify additional relevant articles. Only manuscripts written in English were included. No study design or date exclusions were imposed on this review. Results: This literature review found that CL dropout was frequent across developed countries, with a CL dropout frequency that ranged between 12.0% and 27.4% (pooled mean = 21.7%). The top cited reason for CL dropout in established CL wearers was discomfort, while vision was the top reason in neophyte CL wearers. If given the chance, CL dropouts are often able to successfully resume CL wear up to 74% of the time. While the literature is mixed with regard to factors promoting CL dropout, meibomian gland dysfunction appears to promote CL dropout. Conclusion: CL dropout is a frequently encountered condition that may be curtailed by early detection, patient education, alterative CL options, or early treatment of underlying ocular surface diseases such as meibomian gland dysfunction.

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“…However, it is suggested that DES is related to biochemical, molecular and immune system disturbances. 16 Dry eyes are an unfortunate side effect of radiotherapy. Radiotheraphy causes damage to the cells that leads to necrosis and apoptosis, resulting in the release of inflammatory mediators that are responsible for dry eye syndrome.…”

Section: Dry Eyes In Common Clinical Conditionsmentioning

confidence: 99%