Effects of aflatoxin B₁and fumonisin B₁on body weight, antibody titres and histology of broiler chicks

Abstract

1. Our objective was to evaluate the toxic effects of aflatoxin B1 (AFB1) and fumonisin B1 (FB1), administered singly or in combination to broilers. 2. Feeds were prepared with concentrations equal to 0, 50 and 200 microg AFB1/kg, and/or 0, 50 and 200 mg FB1/kg, and offered to broiler chicks from 8 to 41 d of age. The experimental design was totally randomised, in a 3 x 3 factorial arrangement with 9 treatments and 12 birds per treatment. Animals were vaccinated against Newcastle disease on d 14 of life and killed at 41 d. 3. Compared with controls, all mycotoxin-treated groups at 41 d had lower body weight and weight gain, and higher relative heart weight. The relative weight of the liver increased only in birds fed diets containing 200 mg FB1, singly or in combination with AFB1. 4. At 35 d, all groups receiving mycotoxin-treated rations had reduced geometrical mean antibody titres, with birds from groups fed combinations of AFB1 and FB1/kg having even lower values, when compared to the other groups. 5. Histological changes were observed only in liver from birds fed mycotoxin-contaminated rations, and in kidneys of birds fed the diet containing 200 microg AFB1 and 200 mg FB1/kg. Main alterations included vacuolar degeneration and cell proliferation of bile ducts in the liver, and hydropic degeneration in renal tubules in the kidneys. 6. We concluded that AFB1 and FB1 in combination have primarily additive effects on body weight, liver structure and immunological response of broilers at the concentrations used.

Broyler Piliçlerde Rasyona Katılan Geyikotu Esansiyel Yağının Aflatoksin B1 Toksisitesinin Azaltılmasındaki Etkinliği

“…In consistent with our finding, in some of studies [25,26] chicks received aflatoxin treated ration had lower geometrical mean antibody titers against the Newcastle disease as compared to the control. Antibody titer against NDV significantly increased in group fed diet containing savory alone as compared with the control group.…”

Performance and Nutrient Metabolizability in Broilers Fed Diets Containing Corn Contaminated With Fumonisin B1 and Esterified Glucomannan

“…Xu et al (2011) reported that corn with low nutritional quality affected growth performance due to the presence of mycotoxins and FB1 significantly decreased body weight and feed intake and caused poor feed efficiency in broilers and turkeys. Tessari et al (2006) observed that the dietary contamination with AFB1 and FB1, individually or in combination (at 50 mg/kg and 200 mg/kg, respectively), may adversely affect the body weight, liver structure, and immune responses of broilers. …”

“…The isolation of Fusarium verticillioides and Fusarium proliferatum and the co-occurrence of fumonisins in the same substrate, especially in corn, which is the main feedstuff of poultry feeds, have frequently been reported in literature (Espada et al, 1994, Broomhead et al, 2002Tessari et al, 2006;Tessari et al, 2010). Therefore, the objective of the present study was to evaluate the performance and nutrient metabolizability in broilers fed diets containing corn contaminated with FB1 and with the addition of EGM.…”

Determination of the effects of aflatoxin B1givenin ovoon the proximal tibial growth plate of broiler chickens: histological, histometric and immunohistochemical findings

“…Among them, AFB 1 is the most toxic for most animal species (Leeson et al, 1995;Celik et al, 2000). The toxic effects of AFs in poultry have been widely investigated (Giambrone et al, 1978;Celik et al, 1996;Sur & Celik, 2003) and are a major concern in poultry production because of serious economic losses resulting from anorexia, poor feed utilization, decreased body weight gain, decreased egg production, increased susceptibility to microbial and unspecified diseases and increased mortality (Qureshi et al, 1998;Tessari et al, 2006;Oguz, 2011).…”