Effects of adrenalectomy on energy balance, diet-induced thermogenesis and brown adipose tissue in adult cafeteria-fed rats

Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency

“…Subsequently, the animals were only able to regain their initial weight and did not experience further weight gain. These findings align with previous studies that have demonstrated a substantial influence of adrenalectomy on body weight gain in animals 33 …”

Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency

“…Subsequently, the animals were only able to regain their initial weight and did not experience further weight gain. These findings align with previous studies that have demonstrated a substantial influence of adrenalectomy on body weight gain in animals 33 …”

Diet and the role of 11β-hydroxysteroid dehydrogenase-1 on obesity

“…Solomon and Mayer [2] and Yukimura and Bray [3] were first to implicate glucocorticoids as a necessary factor in genetic obesity, observing that obesity was prevented following bilateral adrenalectomy (ADX) and fully restored by glucocorticoid replacement. Analogous findings were reported for rats fed a cafeteria diet [4] and rats with electrolytic lesions of the ventromedial hypothalamic nuclei [5]. In lean rats, ADX causes an attenuation of the rate of weight gain and a shift in body composition to lessen carcass fat [6].…”

Adrenalectomy Reduces Adiposity by Decreasing Feed Efficiency, Not Direct Effects on White Adipose Tissue

“…We also calculated that ADX reduced feed efficiency by 35%. Similarly, others have found that the gross efficiency of cafeteria-fed, ADX rats was one-fifth that of SHAM-operated controls (30). This decrease in feed efficiency provides strong support for the idea that withdrawal of endogenous glucocorticoids by ADX decreases fat storage by increasing energy expenditure (30, 3 1), probably by increasing GDP binding in brown adipose tissue mitochondria (32).…”

Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency

“…Subsequently, the animals were only able to regain their initial weight and did not experience further weight gain. These findings align with previous studies that have demonstrated a substantial influence of adrenalectomy on body weight gain in animals 33 …”

Diet and the role of 11β-hydroxysteroid dehydrogenase-1 on obesity

“…Solomon and Mayer [2] and Yukimura and Bray [3] were first to implicate glucocorticoids as a necessary factor in genetic obesity, observing that obesity was prevented following bilateral adrenalectomy (ADX) and fully restored by glucocorticoid replacement. Analogous findings were reported for rats fed a cafeteria diet [4] and rats with electrolytic lesions of the ventromedial hypothalamic nuclei [5]. In lean rats, ADX causes an attenuation of the rate of weight gain and a shift in body composition to lessen carcass fat [6].…”

Adrenalectomy Reduces Adiposity by Decreasing Feed Efficiency, Not Direct Effects on White Adipose Tissue

“…We also calculated that ADX reduced feed efficiency by 35%. Similarly, others have found that the gross efficiency of cafeteria-fed, ADX rats was one-fifth that of SHAM-operated controls (30). This decrease in feed efficiency provides strong support for the idea that withdrawal of endogenous glucocorticoids by ADX decreases fat storage by increasing energy expenditure (30, 3 1), probably by increasing GDP binding in brown adipose tissue mitochondria (32).…”

Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency

“…Subsequently, the animals were only able to regain their initial weight and did not experience further weight gain. These findings align with previous studies that have demonstrated a substantial influence of adrenalectomy on body weight gain in animals 33 …”

Diet and the role of 11β-hydroxysteroid dehydrogenase-1 on obesity

“…Solomon and Mayer [2] and Yukimura and Bray [3] were first to implicate glucocorticoids as a necessary factor in genetic obesity, observing that obesity was prevented following bilateral adrenalectomy (ADX) and fully restored by glucocorticoid replacement. Analogous findings were reported for rats fed a cafeteria diet [4] and rats with electrolytic lesions of the ventromedial hypothalamic nuclei [5]. In lean rats, ADX causes an attenuation of the rate of weight gain and a shift in body composition to lessen carcass fat [6].…”

Adrenalectomy Reduces Adiposity by Decreasing Feed Efficiency, Not Direct Effects on White Adipose Tissue

“…We also calculated that ADX reduced feed efficiency by 35%. Similarly, others have found that the gross efficiency of cafeteria-fed, ADX rats was one-fifth that of SHAM-operated controls (30). This decrease in feed efficiency provides strong support for the idea that withdrawal of endogenous glucocorticoids by ADX decreases fat storage by increasing energy expenditure (30, 3 1), probably by increasing GDP binding in brown adipose tissue mitochondria (32).…”