Effects of additional exercise training on epicardial, intra-abdominal and subcutaneous adipose tissue in major depressive disorder: A randomized pilot study

Kahl, K.G.; Kerling, Arno; Tegtbur, Uwe; Gützlaff, E.; Herrmann, Julian B.; Borchert, Luise; Ateş, Zeynep; Westhoff-Bleck, Mechthild; Hueper, Katja; Hartung, Dagmar

doi:10.1016/j.jad.2015.12.015

Cited by 41 publications

(42 citation statements)

References 65 publications

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“…However, part of the effects of exercise may depend on improving feelings of energy and fatigue [ 107 ]. Moreover, evidence supporting the antidepressant effect of exercise is rapidly growing in populations with primary major depressive disorder [ 108 , 109 , 110 , 111 , 112 , 113 ]. Studies are providing methodologically robust evidence on the efficacy of exercise alone for mild and moderate depression, and together with other treatments for severe depression [ 13 , 114 , 115 ].…”

Section: Physical Activity May Narrow the Mortality Gap Of Depressmentioning

confidence: 99%

Physical Activity Promotes Health and Reduces Cardiovascular Mortality in Depressed Populations: A Literature Overview

Murri

Folesani

Zerbinati

et al. 2020

IJERPH

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Major depression is associated with premature mortality, largely explained by heightened cardiovascular burden. This narrative review summarizes secondary literature (i.e., reviews and meta-analyses) on this topic, considering physical exercise as a potential tool to counteract this alarming phenomenon. Compared to healthy controls, individuals with depression consistently present heightened cardiovascular risk, including “classical” risk factors and dysregulation of pertinent homeostatic systems (immune system, hypothalamic–pituitary–adrenal axis and autonomic nervous system). Ultimately, both genetic background and behavioral abnormalities contribute to explain the link between depression and cardiovascular mortality. Physical inactivity is particularly common in depressed populations and may represent an elective therapeutic target to address premature mortality. Exercise-based interventions, in fact, have proven effective reducing cardiovascular risk and mortality through different mechanisms, although evidence still needs to be replicated in depressed populations. Notably, exercise also directly improves depressive symptoms. Despite its potential, however, exercise remains under-prescribed to depressed individuals. Public health may be the ideal setting to develop and disseminate initiatives that promote the prescription and delivery of exercise-based interventions, with a particular focus on their cost-effectiveness.

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Section: Physical Activity May Narrow the Mortality Gap Of Depressmentioning

confidence: 99%

Physical Activity Promotes Health and Reduces Cardiovascular Mortality in Depressed Populations: A Literature Overview

Murri

Folesani

Zerbinati

et al. 2020

IJERPH

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show abstract

“…Physical activity programs improve several cardio-metabolic outcomes in metabolic syndrome patients (22). For depressive patients we observed benefits for abdominal-and cardiac adipose tissues, skeletal muscle mass, aerobic capacity, and brain derived neurotrophic factor following structured exercise interventions (23)(24)(25)(26). Recently, we also reported that self-perceived work ability and quality of life improved after a 6-month exercise-focused occupational health program in workers with metabolic syndrome which may be, at least partly, attributable to the effects of exercise on depression and anxiety severity (27).…”

Section: Introductionmentioning

confidence: 72%

Employers With Metabolic Syndrome and Increased Depression/Anxiety Severity Profit Most From Structured Exercise Intervention for Work Ability and Quality of Life.

et al. 2020

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Background: Major depressive disorder and anxiety disorders are associated with less productivity, earlier retirement, and more sick-days at the workplace. These associations also exist for patients with metabolic syndrome. For both, exercise is a generally recommended part of multimodal treatments. However, for individuals with metabolic syndrome, in which depression and anxiety is more prevalent and severe, evidence for the efficacy of exercise interventions is limited. Methods: Company employees with diagnosed metabolic syndrome (n=314, age: 48 ± 8 yrs) were randomized to a 6-month exercise intervention (150 min per week) or wait-list control. Participants received individual recommendations for exercise activities by personal meetings, telephone, or via a smartphone app. Physical activities were supervised and adapted using activity monitor data transferred to a central database. Work ability (work ability index), depression severity and anxiety severity [hospital anxiety and depression scale (HADS)], and health-related quality of live [short form 36 (SF-36)] were assessed.

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“… 21 As secondary outcomes, the amount of intra-abdominal adipose tissue, pericardial adipose tissue, and muscle mass was measured. 23 Of the original study group, complete data for body composition, including muscle mass, were obtained from 20 patients in the EXERCISE and from 10 in the TAU group. 23 …”

Section: Participants and Methodsmentioning

confidence: 99%

“… 23 Of the original study group, complete data for body composition, including muscle mass, were obtained from 20 patients in the EXERCISE and from 10 in the TAU group. 23 …”

Section: Participants and Methodsmentioning

confidence: 99%

Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial

Kerling¹,

Hartung²,

Stubbs³

et al. 2018

NDT

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ObjectiveSarcopenia leads to physical function impairment and at least to increasing all-cause mortality. There are notes on reduced muscle mass in patients with major depressive disorder (MDD). Whether an exercise intervention counteracts low muscle mass in patients with MDD has not been studied so far. Therefore, our study aimed at examining effects of regular aerobic exercise training on muscle mass in patients with MDD.Participants and methodsThirty inpatients with MDD were included in the study, of which 20 received an additional supervised exercise program. Ten patients obtained treatment as usual. Muscle mass was measured using MRI before and 6 weeks after the training period (3 times per week for 45 minutes).ResultsWe found a significant effect of the exercise intervention on the amount of muscle mass depending on age, body mass index, and the physical activity score (P=0.042).ConclusionAmong other positive effects, regular exercise increases muscle mass in patients with MDD and, therefore, should be recommended as an additional treatment tool.

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Effects of additional exercise training on epicardial, intra-abdominal and subcutaneous adipose tissue in major depressive disorder: A randomized pilot study

Cited by 41 publications

References 65 publications

Physical Activity Promotes Health and Reduces Cardiovascular Mortality in Depressed Populations: A Literature Overview

Physical Activity Promotes Health and Reduces Cardiovascular Mortality in Depressed Populations: A Literature Overview

Employers With Metabolic Syndrome and Increased Depression/Anxiety Severity Profit Most From Structured Exercise Intervention for Work Ability and Quality of Life.

Impact of aerobic exercise on muscle mass in patients with major depressive disorder: a randomized controlled trial

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