Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats

Thomsen, Morgane; Fink-Jensen, Anders; Woldbye, David P. D.; Wörtwein, Gitta; Sager, Thomas N.; Holm, René; Pepe, Lauren M.; Caine, S. Barak

doi:10.1007/s00213-008-1245-1

Cited by 60 publications

(71 citation statements)

References 49 publications

(52 reference statements)

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“…Rate frequency functions were obtained by logarithmically decreasing the frequency of the stimulation pulses from a value that sustained maximal lever pressing to one that failed to sustain lever pressing. studies, showing that Ari counteracts the rewarding/ reinforcing effects of psychostimulants in experimental animals and the subjective and discriminative effects of Amph in humans (Feltenstein et al 2007 ;Lile et al 2005 ;Newton et al 2008 ;Sorensen et al 2008 ;Stoops et al 2006 ;Thomsen et al 2008 ;Wee et al 2007). Ari has been proposed as a potential therapy for psychostimulant dependence (Stoops, 2006) or for the treatment of schizophrenia with comorbid stimulant abuse (Beresford et al 2005).…”

Section: Discussionmentioning

confidence: 97%

Efficacy of the atypical antipsychotic aripiprazole in d-amphetamine-based preclinical models of mania

Mavrikaki

Nomikos

Panagis

2010

Int. J. Neuropsychopharm.

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The atypical antipsychotic aripiprazole has been demonstrated to reduce symptoms of bipolar mania. To further profile the antimanic-like properties of aripiprazole in relevant preclinical models, we examined its efficacy in d-amphetamine-based behavioural models of acute mania in rats. The effects of acute and repeated administration of aripiprazole were assessed in the facilitation of intracranial self-stimulation (ICSS) and hyperlocomotion after acute d-amphetamine, and in the sensitized facilitation of ICSS function and hyperlocomotion after repeated d-amphetamine. Acutely, aripiprazole (0.75, 1.5 and 2.5 mg/kg i.p.) increased ICSS thresholds, attenuated the reward-facilitating effects of d-amphetamine (0.5 mg/kg i.p.), decreased motor activity and prevented d-amphetamine-induced hyperlocomotion. Co-administration of aripiprazole and d-amphetamine for 7 d resulted in aripiprazole counteracting the d-amphetamine-induced sensitization in facilitation of brain reward function and hyperlocomotion. These results indicate the efficacy of aripiprazole in d-amphetamine-based preclinical models of acute mania that are characterized by increased motivational drive and/or hyperfunction of brain reward.

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Section: Discussionmentioning

confidence: 97%

Efficacy of the atypical antipsychotic aripiprazole in d-amphetamine-based preclinical models of mania

Mavrikaki

Nomikos

Panagis

2010

Int. J. Neuropsychopharm.

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“…Remarkably, a complete and long-term suppression of methamphetamine seeking by food choice was also demonstrated in rats after different histories of extended access to methamphetamine self-administration that are known to induce addiction-like behavior (Caprioli et al, 2015a, b). In contrast, in other choice studies, rats eventually shifted their choice from sweet reward to cocaine when the dose of cocaine was sufficiently high (ie, up to 0.5 mg per injection) (Thomsen et al, 2008(Thomsen et al, , 2013.…”

Section: Introductionmentioning

confidence: 87%

“…In studies employing a setting where choosing under the drug influence was not possible (eg, by imposing a sufficiently long interchoice interval for drug dissipation before the next choice), most rats preferred sweet reward over cocaine, even at the high doses . In contrast, in studies using a setting where choosing under the drug influence was possible (eg, by not imposing a minimum interchoice interval), virtually all rats preferred the high doses of cocaine (Thomsen et al, 2008(Thomsen et al, , 2013. Thus, it seems that rats choose cocaine when they are under the drug influence at the time of choice and otherwise choose the nondrug reward.…”

Section: Introductionmentioning

confidence: 94%

Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats

Vandaele

Cantin

Serre

et al. 2015

Neuropsychopharmacol

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Ample evidence shows that the setting can control drug choices in both humans and animals. Here we reveal in rats that a major mechanism of this control involves a regulation of the drug influence on other competing options at the time of choice. Briefly, rats were offered a choice between a drug dose (cocaine or heroin) and a brief access to water sweetened with saccharin in two different settings. In one setting, choosing under the influence was not possible and rats largely preferred saccharin over either cocaine or heroin. In contrast, when the same rats were shifted to a setting where choosing under the influence was possible, they chose the drug either nonexclusively or exclusively depending on whether the drug enhanced or suppressed sweet reward, respectively. Thus, when rats were under the orexigenic influence of heroin at the time of choice, they more frequently chose saccharin in alternation with heroin. In contrast, when rats were under the anorexic influence of cocaine, they stopped choosing saccharin and continued taking cocaine exclusively. These settingand drug-specific changes in preference were rapid and reversible, and could be induced by passively administering cocaine or heroin before choice. Finally, rats behaved as if they were oblivious to the drug influence on their choices. This behavior could explain why rats are vulnerable to harm themselves, sometimes to the point of death, in settings where choices are made under the drug influence, notably if this influence excludes other important options or, conversely, enhances harmful ones.

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“…In other studies, putative D 3 receptor antagonists that decreased cocaine or methamphetamine self-administration did so only at doses that also decreased responding maintained by food (see, eg, Claytor et al, 2006;Martelle et al, 2007;Thomsen et al, 2008;Higley et al, 2011). However, it remains possible that the lack of selective effects on cocaine self-administration in these studies is due to the relatively high D 2 receptor affinity and/or lack of sufficient selectivity for D 3 versus D 2 receptors of the pharmacological tools that were used.…”

Section: Introductionmentioning

confidence: 95%

Effects of Oral and Intravenous Administration of Buspirone on Food–Cocaine Choice in Socially Housed Male Cynomolgus Monkeys

Czoty

Nader

2014

Neuropsychopharmacol

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Drugs acting at D 3 dopamine receptors have been suggested as medications for cocaine dependence. These experiments examined the effects of intravenously and orally administered buspirone, a D2-like receptor antagonist with high affinity for D 3 and D 4 receptors, on the relative reinforcing strength of cocaine in group-housed male cynomolgus monkeys. Use of socially housed monkeys permitted the assessment of whether social status, known to influence D2-like receptor availability, modulates the behavioral effects of buspirone. Buspirone was administered acutely to monkeys self-administering cocaine under a food-drug choice procedure in which a cocaine self-administration dose-effect curve was determined daily. When administered by either route, buspirone significantly decreased cocaine choice in dominant-ranked monkeys. In subordinate monkeys, however, i.v. buspirone was ineffective on average, and oral buspirone increased choice of lower cocaine doses. The effects of buspirone only differed according to route of administration in subordinate monkeys. Moreover, it is noteworthy that the effects of buspirone were similar to those of the D 3 receptor-selective antagonist PG01037 and qualitatively different than those of less selective drugs that act at D2-like or serotonin (5-HT) 1A receptors, suggesting a D 3 and possibly D 4 receptor mechanism of action for buspirone. Taken together, the data support the utility of drugs targeting D 3 /D 4 receptors as potential treatments for cocaine addiction, particularly in combination with enriching environmental manipulations.

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Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats

Cited by 60 publications

References 49 publications

Efficacy of the atypical antipsychotic aripiprazole in d-amphetamine-based preclinical models of mania

Efficacy of the atypical antipsychotic aripiprazole in d-amphetamine-based preclinical models of mania

Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats

Effects of Oral and Intravenous Administration of Buspirone on Food–Cocaine Choice in Socially Housed Male Cynomolgus Monkeys

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