volume 93, issue 0, P2-O-056 2020
DOI: 10.1254/jpssuppl.93.0_2-o-056
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Abstract: Type 1 ryanodine receptor (RyR1) is a Ca 2+ release channel in the sarcoplasmic reticulum and plays an important role in excitation-contraction coupling. Genetic mutations in RyR1 cause various skeletal muscle diseases including malignant hyperthermia (MH). Since the main underlying mechanism of MH is hyperactive Ca 2+ release by gain-offunction of the RyR1 channel, inhibition of RyR1 is a promising treatment for the disease. We have recently developed an efficient high-throughput screening platform for the Ry…

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