Effects of a New Sulfonamide Combination on Experimental Pyelonephritis

Abstract

Preventive effect of a sulfamethizole-sulfaethidole combination on experimental hematogenous pyelonephritis was examined on 120 white rats weighing 200–250 g. Two strains of Staphylococcus aureus, one of which was resistant to the combination and the other sensitive, and a resistant enterococcus strain were used for experimental hematogenous pyelonephritis. As a result, we observed that this kind of sulfonamide combination improved the pathomorphological lesions only in the group in which experimental pyelonephritis was produced by sensitive S. aureus. In the other groups, practically no positive effect could be seen.

Preventive Effects of Trimethoprim, Sulphamethoxazole and the Combination Trimethoprim/Sulphamethoxazole on Experimental Staphylococcic Pyelonephritis in Rats

“…We do not claim that other sulfonamide combinations or anti biotics have no such favorable effect on experimental pyelonephritis caused by the same strain of Staphylococcus aureus, but we do claim that all other sulfonamide combinations or antibiotics used previously (i.e. Hamosal®; sulphaethidole + sulphamethiozole; TAD Pharmazeutisches Werk GmbH, Cuxhaven, FRG, and gentamicin) [13,14] have not shown such favorable effects.…”