2017
DOI: 10.1371/journal.pone.0176083
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Abstract: BackgroundChildren who were only exposed to a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) as humidifier disinfectant (HD) components were evaluated for humidifier disinfectant-associated lung injury (HDLI) from 2012. This study was to evaluate the pulmonary function using, impulse oscillometry (IOS) for children exposed to a mixture of CMIT/MIT from HD.MethodsTwenty-four children who were only exposed to a mixture of CMIT/MIT, with no previous underlying disease, were assessed… Show more

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Cited by 23 publications
(25 citation statements)
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References 48 publications
(52 reference statements)
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“…Their biocide activity also encourages their use in humidifier disinfectant and air conditioning systems. 1 Following the definite increase in isothiazolinone-associated contact allergy rates in Europe, 2 MCI/MI and MI are forbidden in leave-on cosmetics and allowed in rinse-off cosmetics up to max of 15 ppm. Concerning non-cosmetic products (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Their biocide activity also encourages their use in humidifier disinfectant and air conditioning systems. 1 Following the definite increase in isothiazolinone-associated contact allergy rates in Europe, 2 MCI/MI and MI are forbidden in leave-on cosmetics and allowed in rinse-off cosmetics up to max of 15 ppm. Concerning non-cosmetic products (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…The information on the toxicity of CMIT/MIT mixture and individual component is limited, although the toxicity and reactivity of CMIT has been reported to be more potent than MIT (Cho et al, 2017). The carcinogenicity of CMIT was ruled out by IARC (Kahrilas et al, 2014), but chronic and high exposure can cause a detrimental effect at DNA and cellular level.…”
Section: Resultsmentioning
confidence: 99%
“…Recently, significant peripheral airway dysfunction has been reported in children with high-level inhalation exposure to a mixture of CMIT/MIT (Cho et al, 2017). CMIT/MIT mixture has been registered as a secondary inhalation toxicant by US Environmental Protection Agency (EPA).…”
Section: Introductionmentioning
confidence: 99%
“…In real clinical situations in humans, HD-ILDs had been occurred after exposure to CMIT and MIT, which showed similar patterns of pulmonary inflammation and fibrosis as those associated with exposure to PHMG and PGH. [26][27][28] A possible degree of association means cases with incomplete clinical features and radiological and pathological findings of HD-ILDs and therefore needs additional considerations on other subtypes of ILDs.…”
Section: Health Effects Of Toxic Chemicals In Hdsmentioning
confidence: 99%