Effects of a microbial muramidase on the growth performance, intestinal permeability, nutrient digestibility, and welfare of broiler chickens

New Insights into the Effects of Microbial Muramidase Addition in the Diets of Broiler Chickens

“…Gong et al [ 10 ] observed that adding lysozyme to broiler diets did not influence growth performance. Goes et al [ 25 ] reported improved FCR in broiler chickens fed a diet included with MUR throughout the whole experimental period and improved BWG and FCR of intestinally challenged chickens fed on MUR (35,000 LSU (F)/kg). They also established that MUR supplementation reduced intestinal permeability, enhanced intestinal barrier function, increased nutrient digestibility, and raised the total carotenoids in blood.…”

“…Weaned pigs fed diets including a water-soluble HEW lysozyme exhibited taller villi in the ileum [ 54 ]. The improved membrane integrity, nutrient digestion, and absorption by MUR are likely due to its effect on bacterial PGN hydrolysis [ 25 ].…”

“…Several studies have also been performed, with varying degrees of success, on how dietary enzymes impact poultry productivity [ 10 , 20 , 21 , 22 , 23 , 24 ]. However, several factors, such as composition, administrative levels, durations, and methodologies, as well as the age of the birds, affected how the poultry reacted to the enzymes [ 19 , 25 ]. The amount of study on the effects of microbial MUR on productivity and meat quality in broilers is still limited.…”

Dietary muramidase increases ileal amino acid digestibility of wheat and corn-based broiler diets without affecting endogenous amino acid losses

“…Previous work has shown that MUR supplementation in broilers diets improves FCR, increases digestibility of protein ( Goodarzi Boroojeni et al, 2019 ) and crude fat ( Sais et al, 2020 ; Pirgozliev et al, 2021 ; Goes et al, 2022 ) and absorption of fat-soluble vitamins and carotenoids ( Sais et al, 2020 ; Goes et al, 2022 ) but the contribution of changes in endogenous nutrient flow to these effects is not known.…”

“…Recently muramidase derived from the fungus Acremonium alcalophilum has become available as a new category of feed enzymes which the substrate is not present in the feed but already present in the GIT. Several studies have demonstrated that MUR improves broiler performance by enhancing nutrient digestibility and absorption ( Goodarzi Boroojeni et al, 2019 ; Sais et al, 2020 ; Goes et al, 2022 ) and energy availability ( Pirgozliev et al, 2021 ; Goes et al, 2022 ). However, those previous studies did not show a consistent positive effect on the same nutrients digestibility, as for example CP.…”