Effects of a Corneal Anesthetic on Extinction of the Classically Conditioned Nictitating Membrane Response in the Rabbit (Oryctolagus cuniculus).

Robleto, Karla; Poulos, Andrew M.; Thompson, Richard F.

doi:10.1037/0735-7044.118.6.1433

Cited by 4 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taken together, these findings suggest that continued expression of a CR may be required for extinction learning and its transfer. This conclusion regarding the importance of response expression to extinction is consistent with most of the Pavlovian conditioning research using exteroceptive stimuli (e.g., Rescorla, 1993, 2001; Robleto et al, 2004). …”

Section: Discussionsupporting

confidence: 88%

Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine

et al. 2010

View full text Add to dashboard Cite

The interoceptive stimulus effects of nicotine acquire control over behavior. This observation, among others, suggests that the stimulus effects of nicotine are important in the development and tenacity of tobacco dependence. Despite this importance, there has been little research examining whether non-reinforced presentations (extinction) of a ligand that share stimulus effects of nicotine will weaken responding controlled by nicotine. Rats were trained to discriminate nicotine (0.4 mg/kg) from saline using a discriminated goal-tracking task in which nicotine signaled intermittent access to sucrose; sucrose was withheld on saline sessions. Experiment 1 examined substitution for nicotine by ABT-418, nornicotine, epibatidine, varenicline, or cytisine in 4-min extinction tests. Experiments 2 to 5 [low dose nicotine (0.05 mg/kg), ABT-418, nornicotine, or varenicline, respectively] examined whether substitution for nicotine would persist if extinction tests were increased to 20 min and repeated daily for 6 days. Finally, generalization of this extinction back to the nicotine training stimulus was assessed. Full substitution in brief 4-min extinction tests was seen for ABT-418, nornicotine, epibatidine, varenicline, and cytisine. Low-dose nicotine, ABT-418, nornicotine, and varenicline, evoked only a partial 'nicotine-like' response in the first 20-min extinction test. With repeated extinction, only low-dose nicotine, nornicotine, and varenicline continued to substitute. Extinction with nornicotine and varenicline transferred back to nicotine as indicated by a partial conditioned response to the training stimulus. Interpretations regarding 'nicotine-like' effects of a ligand depend on the nature of the test. Understanding the processes mediating transfer of extinction learning with potential pharmacotherapies may reveal new treatment targets.

show abstract

Section: Discussionsupporting

confidence: 88%

Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine

et al. 2010

View full text Add to dashboard Cite

show abstract

“…We have replicated this result using very low doses of muscimol (1 µg in 0.1 µL) infused in the interpositus (Robleto and Thompson 2003). On the basis of earlier studies (Krupa et al 1993) actions of these very doses do not appear to spread beyond the interpositus.…”

Section: Neuronal Substrates Of Extinctionsupporting

confidence: 70%

Brain Mechanisms of Extinction of the Classically Conditioned Eyeblink Response

Robleto¹,

Poulos²,

Thompson³

2004

Learn. Mem.

Self Cite

View full text Add to dashboard Cite

It is well established that the cerebellum and its associated circuitry are essential for classical conditioning of the eyeblink response and other discrete motor responses (e.g., limb flexion, head turn, etc.) learned with an aversive unconditioned stimulus (US). However, brain mechanisms underlying extinction of these responses are still relatively unclear. Behavioral studies have demonstrated extinction as an active learning process distinct from acquisition. Experimental data in eyeblink conditioning suggest that plastic changes specific to extinction may play an important role in this process. Both cerebellar and hippocampal systems may be involved in extinction of these memories. The nature of this phenomenon and identification of the neural substrates necessary for extinction of originally learned responses is the topic of this review.

show abstract

Extinction of conditioned eyeblink responses in patients with cerebellar disorders

Gerwig

Hajjar

Frings

et al. 2006

Neuroscience Letters

View full text Add to dashboard Cite

Effects of a Corneal Anesthetic on Extinction of the Classically Conditioned Nictitating Membrane Response in the Rabbit (Oryctolagus cuniculus).

Cited by 4 publications

References 16 publications

Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine

Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine

Brain Mechanisms of Extinction of the Classically Conditioned Eyeblink Response

Extinction of conditioned eyeblink responses in patients with cerebellar disorders

Contact Info

Product

Resources

About