Effects of a calcium phosphate coating on the osseointegration of endosseous implants in a rabbit model

Fontana, Filippo; Rocchietta, Isabella; Addis, Alessandro; Schüpbach, Peter; Zanotti, Gianfranco; Simion, Massimo

doi:10.1111/j.1600-0501.2010.02056.x

Cited by 29 publications

(28 citation statements)

References 27 publications

(32 reference statements)

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“…After 12 weeks of healing, the HA-coated implants still possessed higher BIC than the controls, but without significant difference. This trend has been confirmed in several previous studies evaluating thin coating layers [24,25,26]. Our finding with regard to a stronger bone reaction to test implants is supported by our previous biomechanical study on similar test and control implants [27].…”

Section: Discussionsupporting

confidence: 91%

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

et al. 2015

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Polyether ether ketone (PEEK) has been frequently used in spinal surgery with good clinical results. The material has a low elastic modulus and is radiolucent. However, in oral implantology PEEK has displayed inferior ability to osseointegrate compared to titanium materials. One idea to reinforce PEEK would be to coat it with hydroxyapatite (HA), a ceramic material of good biocompatibility. In the present study we analyzed HA-coated PEEK tibial implants via histology and radiography when following up at 3 and 12 weeks. Of the 48 implants, 24 were HA-coated PEEK screws (test) and another 24 implants served as uncoated PEEK controls. HA-coated PEEK implants were always osseointegrated. The total bone area (BA) was higher for test compared to control implants at 3 (p < 0.05) and 12 weeks (p < 0.05). Mean bone implant contact (BIC) percentage was significantly higher (p = 0.024) for the test compared to control implants at 3 weeks and higher without statistical significance at 12 weeks. The effect of HA-coating was concluded to be significant with respect to early bone formation, and HA-coated PEEK implants may represent a good material to serve as bone anchored clinical devices.

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Section: Discussionsupporting

confidence: 91%

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

et al. 2015

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“…25,28,29 The rabbit tibia is an accepted animal model for biomaterial research and technically favorable. 33 The biocompatibility of the SMBM material was proved in an earlier study and was reproducible in this experiment. The Alfa Gate dental implants are advantageous for bony healing due to their calcium phosphate coating.…”

Section: Discussionsupporting

confidence: 68%

Vertical Bone Augmentation with Simultaneous Dental Implantation Using Crestal Biomaterial Rings: A Rabbit Animal Study

Draenert

Kämmerer

Palarie

et al. 2011

Clin Implant Dent Rel Res

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“…The effects of surface modification with calcium phosphate have received mixed reviews in the literature. Some research groups show positive effects of these coatings on bone regeneration and the mechanical properties of the coated biomaterials , whereas others show no beneficial effects of the coating with respect to bone regeneration (Ekholm et al 2005;Fontana et al 2011). It should be noted, however, that most of the defects treated in the aforementioned studies were small bone defects (not critical-sized, thereby able to heal unassisted) or were studies to demonstrate the effects of surface modification on implant ingrowth (Fontana et al 2011;Mihalko et al 2010).…”

Section: Discussionmentioning

confidence: 91%

Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration

et al. 2012

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There is a growing need for successful bone tissue engineering strategies and advanced biomaterials that mimic the structure and function of native tissues carry great promise. Successful bone repair approaches may include an osteoconductive scaffold, osteoinductive growth factors, cells with an osteogenic potential and capacity for graft vascularisation. To increase osteoinductivity of biomaterials, the local combination and delivery of growth factors has been developed. In the present study we investigated the osteogenic effects of calcium phosphate (CaP)-coated nanofiber mesh tube-mediated delivery of BMP-7 from a PRP matrix for the regeneration of critical sized segmental bone defects in a small animal model. Bilateral full-thickness diaphyseal segmental defects were created in twelve male Lewis rats and nanofiber mesh tubes were placed around the defect. Defects received either treatment with a CaP-coated nanofiber mesh tube (n = 6), an un-coated nanofiber mesh tube (n=6) a CaP-coated nanofiber mesh tube with PRP (n=6) or a CaP-coated nanofiber mesh tube in combination with 5 μg BMP-7 and PRP (n = 6). After 12 weeks, bone volume and biomechanical properties were evaluated using radiography, microCT, biomechanical testing and histology. The results demonstrated significantly higher biomechanical properties and bone volume for the BMP group compared to the control groups. These results were supported by the histological evaluations, where BMP group showed the highest rate of bone regeneration within the defect. In conclusion, BMP-7 delivery via PRP enhanced functional bone defect regeneration, and together these data support the use of BMP-7 in the treatment of critical sized defects.

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Effects of a calcium phosphate coating on the osseointegration of endosseous implants in a rabbit model

Abstract: In conclusion, findings from the present study suggested that the Ca-P coating had no beneficial effect in improving bonding strength at the bone-implant interface either at 2, 4 and 9 weeks.

Cited by 29 publications

References 27 publications

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone

Vertical Bone Augmentation with Simultaneous Dental Implantation Using Crestal Biomaterial Rings: A Rabbit Animal Study

Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration

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