1998
DOI: 10.1080/095530098142761
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Abstract: These results support the proposed tumour-promoting effect of MF, but do not suggest an important role for increased ODC activity in this process.

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Cited by 39 publications
(16 citation statements)
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“…However, several studies with combined exposures have suggested that MF might enhance the effects of known DNA damaging agents [1], [2], [3]. Similarly, carcinogenicity studies in animals have not generally reported effects from MF alone, but studies with combined exposures have provided some evidence for cocarcinogenicity of MF [4], [5].…”
Section: Introductionmentioning
confidence: 99%
“…However, several studies with combined exposures have suggested that MF might enhance the effects of known DNA damaging agents [1], [2], [3]. Similarly, carcinogenicity studies in animals have not generally reported effects from MF alone, but studies with combined exposures have provided some evidence for cocarcinogenicity of MF [4], [5].…”
Section: Introductionmentioning
confidence: 99%
“…A second positive result used the same model system but involved a different neoplastic end point (49), which precluded direct comparison. The third positive result was obtained in an unvalidated assay system employing UV light as inducer (56). None of these studies were comparable to the others.…”
Section: Discussionmentioning
confidence: 63%
“…Third, a positive control was not included; this would have been helpful to assist in validating the new assay. Finally, a puzzling feature of the study, as discussed by investigators, is the apparent lack of any increase over UVexposed controls in the terminal incidence of histologically verified papillomas or squamous cell carcinomas in MF-+ UV-exposed transgenic or nontransgenic animals compared to the 2-to 3-fold increase in epidermal cysts in the MF-+ UV-exposed transgenics (56).…”
Section: Resultsmentioning
confidence: 95%
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“…Since humans are exposed to various combinations of an array of different carcinogens at changeable levels, exposure to ELF-MF could potentially act in a promotor, co-promotor or enhancer through either simultaneous or sequential exposure, ultimately contributing towards tumour progression (Juutilainen et al, 2000). Indeed a study had previously reported that mice experienced enhanced skin tumorigenesis when exposed to UV radiation in conjunction with magnetic fields (Kumlin et al, 1998). Additionally, evidence was presented that 50/60 Hz magnetic field exposure at flux densities of 50 and 400 mT potentiated a small but significant increase in the X-ray induced DNA strand breaks in human glioma cells .…”
Section: Combined Elf and Carcinogen Exposurementioning
confidence: 99%