Effects of 4 major brain protection strategies during aortic arch surgery

Fan, Shulei; Wang, Daoxing; Wu, Chun; Pan, Zhengxia; Li, Yonggang; An, Youzhong; Li, Hongbo; Wang, Gang; Dai, Jiangtao; Wang, Quan

doi:10.1097/md.0000000000011448

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…[ 18 ] The network geometry will indicate the interactions among all the included studies, and the contributions of direct comparisons will be shown in the contribution plot for the network. [ 19 ] The effects of every intervention on both the incidence of HE and the functional outcome in sICH patients will be assessed using mean ranks and the surface under the cumulative ranking curve. [ 20 ]…”

Section: Methodsmentioning

confidence: 99%

Comparison of hemostatic agents in patients with spontaneous intracerebral hemorrhage

Zheng

Zhou

et al. 2020

Medicine

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Background: Spontaneous intracerebral hemorrhage (sICH) is a serious stroke subtype. The effective therapies for patients with sICH are still unclear, and the role of hemostatic agents in sICH is still unclear. Although some studies have shown that hemostatic agents could benefit patients with sICH, different hemostatic drugs have different effects on patients with sICH, and which hemostatic drug has the best effect on the prevention of hematoma expansion and neurological deterioration in sICH patients remains unclear. To better understand the effects of hemostatic agents in patients with sICH, it is necessary to carry out a network meta-analysis to comprehensively compare the effects of different hemostatic agents. Methods: This protocol has been designed following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. Related studies in the following databases will be searched until September 2020: PubMed, Embase, Scopus, Web of Science, the Cochrane Library, China National Knowledge Infrastructure, VIP and Wanfang. Randomized controlled trials and nonrandomized controlled studies comparing at least 2 different hemostatic agents in sICH patients will be included. A quality assessment will be conducted with the Cochrane Collaboration tool or the Newcastle-Ottawa Scale based on the study design. The primary outcome will be the incidence of hematoma expansion, and the secondary outcome will be the functional outcome. Pairwise and network meta-analyses will be conducted using STATA V.14 (StataCorp, College Station, Texas, USA). Mean ranks and the surface under the cumulative ranking curve will be used to evaluate every agent. Statistical inconsistency assessment, subgroup analysis, sensitivity analysis and publication bias assessment will be performed. Results: According to disseminate through academic conferences, the results of this network meta-analysis are expected to publish in a peer-reviewed journal. Conclusion: This study will provide high quality evidence about effects of different hemostatic agents in patients with sICH. Registration number: CRD42020196039.

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Section: Methodsmentioning

confidence: 99%

Comparison of hemostatic agents in patients with spontaneous intracerebral hemorrhage

Zheng

Zhou

et al. 2020

Medicine

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“…Network meta-analysis will be performed with a random effects model reported in the previous study 16. Interactions among all included studies will be shown in the network geometry, and the contribution plot for the network will show the contributions of direct comparisons 17. Mean ranks and the surface under the cumulative ranking curve will be used to evaluate every intervention for both functional outcome and mortality in patients with sICH 18…”

Section: Methods and Analysismentioning

confidence: 99%

Comparison of surgical strategies in patients with spontaneous intracerebral haemorrhage: a protocol for a network meta-analysis

Zheng

et al. 2019

BMJ Open

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IntroductionSpontaneous intracerebral haemorrhage (sICH) is a severe stroke subtype. The effective therapies for patients with sICH are still unclear, and the role of surgical treatment in sICH management is still controversial. Although some large trials did not show that surgery could benefit patients with sICH, some other studies suggested that some specific surgical strategies can have potential benefits to these patients. For a better understanding of the surgical treatment in patients with sICH, it is necessary to conduct a network meta-analysis to compare the effects of medical treatment and different surgical methods comprehensively.Methods and analysisThis protocol has been reported following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. Related studies until August 2018 will be searched in the following databases: PubMed, Embase, Scopus, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP and Wanfang. Randomised controlled trials and non-randomised prospective studies comparing at least two different interventions in patients with sICH will be included. Quality assessment will be conducted using Cochrane Collaboration’s tool or Newcastle-Ottawa Scale based on their study designs. The primary outcome will be functional outcome and the secondary outcome will be mortality. Pairwise and network meta-analysis will be conducted using STATA V.14 (StataCorp, College Station, Texas, USA). Mean ranks and the surface under the cumulative ranking curve will be used to evaluate every intervention. Statistical inconsistency assessment, subgroup analysis, sensitivity analysis and publication bias assessment will be performed.Ethics and disseminationEthics approval is not necessary because this study will be based on publications. The results of this study will be published in a peer-reviewed journal.PROSPERO registration numberCRD42018112239

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“…Network meta-analysis (NMA) is a new method that employs Bayesian statistical theory. [ 19 ] Although aerobic exercise, such as Taijiquan, jogging, and swimming, is generally believed to be beneficial to patients with type 2 diabetes, the above interventions are hardly measurable. To address this question, Bayesian NMA enables a comprehensive analysis through integrating all direct and indirect evidence to compare various interventions.…”

Section: Introductionmentioning

confidence: 99%

“…However, there are many types of aerobic exercise styles in T2DM, and little attention has been paid to the ranking of aerobic exercise effectiveness. Network meta-analysis (NMA) is a new method that employs Bayesian statistical theory [19] . Although aerobic exercise, such as Taijiquan, jogging, and swimming, is generally believed to be beneficial to patients with type 2 diabetes, the above interventions are hardly measurable.…”

Section: Introductionmentioning

confidence: 99%

Effects of different aerobic exercise training on glycemia in patients with type 2 diabetes

Liu

et al. 2021

Medicine

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Background: Type 2 diabetes is an emergent worldwide health crisis, and rates are growing globally. Aerobic exercise is an essential measure for patients with diabetes, which has the advantages of flexible time and low cost. Aerobic exercise is a popular method to reduce blood glucose. Due to the lack of randomized trials to compare the effects of various aerobic exercises, it is difficult to judge the relative efficacy. Therefore, we intend to conduct a network meta-analysis to evaluate these aerobic exercises. Methods: According to the retrieval strategies, randomized controlled trials on different aerobic exercise training will be obtained from China National Knowledge Infrastructure, WanFang, SinoMed, PubMed, Web of Science, EMBASE, and Cochrane Library, regardless of publication date or language. Studies were screened based on inclusion and exclusion criteria, and the Cochrane risk bias assessment tool will be used to evaluate the quality of the literature. The network meta-analysis will be performed in Markov Chain Monte Carlo method and carried out with Stata14 and OpenBUGS software. Ultimately, the evidentiary grade for the results will be evaluated. Results: Eighteen literatures with a total of 1134 patients were included for the meta-analysis. In glycemia assessment, Tennis (standard mean difference = 3.59, credible interval 1.52, 5.65), had significantly better effects than the named control group. Tennis (standard mean difference = 3.50, credible interval 1.05, 5.59), had significantly better effects than the named Taiji group. Conclusion: All together, these results suggest that tennis may be the best way to improve blood glucose in patients with type 2 diabetes. This study may provide an excellent resource for future control glycemia and may also serve as a springboard for creative undertakings as yet unknown.

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Effects of 4 major brain protection strategies during aortic arch surgery

Cited by 6 publications

References 20 publications

Comparison of hemostatic agents in patients with spontaneous intracerebral hemorrhage

Comparison of hemostatic agents in patients with spontaneous intracerebral hemorrhage

Comparison of surgical strategies in patients with spontaneous intracerebral haemorrhage: a protocol for a network meta-analysis

Effects of different aerobic exercise training on glycemia in patients with type 2 diabetes

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