Effects of 3 Topical Plant Extracts on Wound Healing in Beef Cattle

Lipinski, Leandro Cavalcante; Wouk, Antônio Felipe Paulino de Figueiredo; Silva, Nilceu Lemos da; Perotto, Daniel; Ollhoff, Rüdiger Daniel

doi:10.4314/ajtcam.v9i4.11

Cited by 15 publications

(19 citation statements)

References 20 publications

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“…In another study, rats with cutaneous lesions were treated with ointment containing 5% leaf oil, resulting in improved wound healing 10 . Similar findings of improved healing of cutaneous wounds in beef cattle have also been observed following treatment with bark extract for 17 days 11 . Improved clotting and establishment of a fibrin net in the wounds was also observed 11 .…”

supporting

confidence: 79%

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Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models

Muhs

Lyles

Parlet

et al. 2017

Sci Rep

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Widespread antibiotic resistance is on the rise and current therapies are becoming increasingly limited in both scope and efficacy. Methicillin-resistant Staphylococcus aureus (MRSA) represents a major contributor to this trend. Quorum sensing controlled virulence factors include secreted toxins responsible for extensive damage to host tissues and evasion of the immune system response; they are major contributors to morbidity and mortality. Investigation of botanical folk medicines for wounds and infections led us to study Schinus terebinthifolia (Brazilian Peppertree) as a potential source of virulence inhibitors. Here, we report the inhibitory activity of a flavone rich extract “430D-F5” against all S. aureus accessory gene regulator (agr) alleles in the absence of growth inhibition. Evidence for this activity is supported by its agr-quenching activity (IC50 2–32 μg mL−1) in transcriptional reporters, direct protein outputs (α-hemolysin and δ-toxin), and an in vivo skin challenge model. Importantly, 430D-F5 was well tolerated by human keratinocytes in cell culture and mouse skin in vivo; it also demonstrated significant reduction in dermonecrosis following skin challenge with a virulent strain of MRSA. This study provides an explanation for the anti-infective activity of peppertree remedies and yields insight into the potential utility of non-biocide virulence inhibitors in treating skin infections.

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supporting

confidence: 79%

“…Similar findings of improved healing of cutaneous wounds in beef cattle have also been observed following treatment with bark extract for 17 days 11 . Improved clotting and establishment of a fibrin net in the wounds was also observed 11 . A summary of reported antimicrobial bioactivity of this species is provided in Suppl.…”

supporting

confidence: 79%

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models

Muhs

Lyles

Parlet

et al. 2017

Sci Rep

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“…The macroscopic analysis of the lesions suggests that C. sylvestris extract Sw. showed a positive result in skin lesions. Similar results were observed in cattle, only during the first 2 days of treatment with the C. sylvestris Sw. [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Healing activity of Casearia sylvestris Sw. in second-degree scald burns in rodents

et al. 2015

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BackgroundEvery year thousands of people are victims of burns, mainly scald burns. Many of these victims have small size wounds and superficial partial thickness and do not seek specialized medical care. As in Brazil Casearia sylvestris Sw., popularly known as guaçatonga is widely used for its analgesic, antiseptic and anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries.MethodsThe obtained extract was validated applying a thin layer chromatography and sophisticated validation method using Bothrops jararacussu snake venom that is necrotic and inflammatory, and by which guaçatonga extract was able to neutralize the irreversible neuromuscular blockade induced by the venom. After induction of the scald injury, the animals were treated daily with saline solution spray; spray containing extract; biofilm; or biofilm impregnated with extract.ResultsSignificant differences were observed between the four groups studied considering: extension of the healing area, neovascularization, fibroblast proliferation, and epithelialization.ConclusionThe anti-inflammatory and bactericidal effects of C. sylvestris Sw. suggests a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B. jararacussu venom.

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“…However Estevão et al 17 and Lipinski et al 18 show the aroeira oil had a beneficial effect on wound healing by second intention.…”

Section: Introductionmentioning

confidence: 98%

Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)

et al. 2015

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PURPOSE:To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in rats. METHODS:Twenty rats, male, of adult age, were submitted to skin surgery on the right (RA) and left antimeres (LA) of the thoracic region. They were divided into two groups: control (RA -wounds receiving daily topical application of vaseline and lanolin) and treated (LA -wounds treated daily with the topical ointment). The skin region with wounds were collected at days 4, 7, 14 and 21 after surgery.Those were fixed in 10% formaldehyde and later processed for paraffin embedding. Sections were obtained and stained by H.E for histopathology analysis. The degree of epithelial contraction was measured and mast cell concentration were also evaluated. RESULTS:The treated group showed higher mast cell concentrations (p<0.05) associated with increased contraction at day 7 and 14 respectively. CONCLUSION:Ointment containing 5% Brazilian pepper tree oil increases mast cell concentration and promotes skin wound contraction in rats.

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Effects of 3 Topical Plant Extracts on Wound Healing in Beef Cattle

Cited by 15 publications

References 20 publications

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models

Healing activity of Casearia sylvestris Sw. in second-degree scald burns in rodents

Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)

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