“…PA/exercise might be a way to improve the gut microbiome during ageing since it influences several organs, cells, and tissues, and involves several molecular pathways. Previous studies have shown that PA/exercise have several benefits during the ageing process such as improvements in cognitive function [ 55 , 56 ], promotion of cardiovascular health [ 57 ] and improvements in the musculoskeletal system [ 58 , 59 , 60 ], making it a precious tool to counteract the age-associated changes that occur in those systems. Besides the benefits mentioned previously, recent studies [ 61 , 62 , 63 , 64 ] on the effects of exercise on the gut microbiome of older people have suggested that exercise might beneficially affect its composition and even reverse some age-associated taxonomical changes, ultimately leading towards healthy ageing.…”