Effects and mechanisms of Clematis mandshurica Maxim. as a dual inhibitor of proinflammatory cytokines on adjuvant arthritis in rats

Suh, Suk-Jong; Kim, Kap‒Sung; Lee, Seung-Deuk; Lee, Chang Hwan; Choi, Hoon; Jin, Un‐Ho; Chang, Young‐Chae; Kim, Cheorl-Ho

doi:10.1016/j.etap.2006.03.010

Cited by 13 publications

(9 citation statements)

References 25 publications

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“…However, the significant decreased histamine release was inhibited by the extracts treated groups, this indicates this plant has mast cell membrane stabilizing property. The decreased level of TNF-α and IL-1β, indicates the suppression of macrophages and neutrophil, indicating the reduced infiltration of inflammatory mediator (Suk-Jong Suh et al, 2006). In the present study, the hematological parameters like WBC, RBC, Haemoglobin, MCH, MCHC, HCT, Lymphocytes and E.S.R were increased except the level of MCV and platelets are decreased in the arthritis control group.…”

Section: Discussionsupporting

confidence: 49%

Anti-arthritic activity of <i>Indigofera tinctoria</i> L on adjuvant induced arthritis

Katti¹,

Chandrasekhar²,

Ramkishan³

et al. 2016

Sci. Technol. Arts Res. J.

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Indigofera tinctoria L has long been traditionally employed for various diseases, including pain and inflammation. The present study is an attempt to evaluate the potential anti activity of Indigofera tinctoria L. The antiarthritic activity for petroleum ether and ethanol extracts (100, 200 and 300 mg/kg) of Indigofera tinctoria Freunds Complete Adjuvant (FCA) at the tibiotorsal joint. permeability, histamine, hematological parameters, ESR, evaluation of development of arthritis, biochemical parameters, and Interleukin (IL) Spleen cells (MTT assay), Radiographic analysis and histopathological assessments were carried out. The petroleum ether and ethanol extracts of anti-arthritic activity, by significant changes in the behavior permeability, histamine level, IL and TNF, proliferation of spleenocytes dose Similarly the significant increased SOD, GSH and reduced level of lipid peroxidation and decreased ESR, WBC's and lymphocytes were ob resorption were also reduced. The infiltration of leucocytes and loss of articular cartilage was significantly reduced in groups treated with the extracts. extracts of Indigofera tinctoria L showed the potent anti arthritis in rats.

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Section: Discussionsupporting

confidence: 49%

Anti-arthritic activity of <i>Indigofera tinctoria</i> L on adjuvant induced arthritis

Katti¹,

Chandrasekhar²,

Ramkishan³

et al. 2016

Sci. Technol. Arts Res. J.

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“…This assay nonetheless gave a clear indication of toxicity against HeLa cells through indications of cell shrinkage or cells floating following exposure to the extracts (carrier solvent controls did not show any of these indicators of toxicity). The active species from this set, for which previous studies exist, include Turkish (Yesilada et al, 1997;Yesilada and Kupeli, 2007), East Asian (Suh et al, 2006;Park et al, 2006a) and Australian species of Clematis ; species of Artemisia from China (Jin et al, 2004;Lee et al, 2007) and Tibet (Sun et al, 2006). As identified in Jin et al (2004) sesquiterpene lactones are the likely NF-B inhibitors found in extracts of Artemisia spp.…”

Section: Speciesmentioning

confidence: 97%

Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators

Bremner¹,

Rivera

Calzado

et al. 2009

Journal of Ethnopharmacology

100

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“…Treatment of TCDCA with different concentration resulted in marked augmentation of IκBα protein and reduction of phospho-IκBα protein level in the cytoplasmic fractions of peritoneal macrophages. RA is a chronic autoimmune disease associated with multiple inflammatory mediators that lead to joint damage, synovial inflammation and cartilage and bone damage [14,15]. Nowadays, there is dramatically growing interest in herbal medicines among persons with RA and in RA research community.…”

Section: Effects Of Tcdca On Expression Of Iκbα and Phospho-iκbαmentioning

confidence: 99%

Taurochenodeoxycholic Acid Suppresses NF-κB Activation and Related Cytokines Expression in Peritoneal Macrophages from Adjuvant Arthritis Rat

Mao¹,

Liu²,

Guan³

et al. 2018

Rec.Nat.Prod.

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Taurochenodeoxycholic acid (TCDCA) is one of main bioactive substances of animals' bile acid and confers good anti-inflammatory activity. This study aimed to investigate the mechanism of the anti-adjuvant arthritis activity of TCDCA, the actions were observed in vitro on the protein and mRNA expression of cytokines, the activity of nuclear factor-kappa B (NF-κB) and its inhibitory IκBα protein level of peritoneal macrophages (PMs) in adjuvant arthritis (AA) rats. In a definite concentration ranging from 150 μg/mL to 200 μg/mL, the over protein and mRNA expression of TNF-α, IL-1β and IL-6 were remarkably suppressed in the supernatant of PMs treatment with TCDCA. Positive correlations were found between changes of NF-κB activity and expression of TNF-α, IL-1β and IL-6 influenced by TCDCA. The activity of NF-κB was markedly inhibited and IκBα protein level was increased by TCDCA (150 μg/mL,180 μg/mL and 200 μg/mL). TCDCA suppresses the protein and mRNA expression of TNF-α, IL-1β, and IL-6 by inhibiting the NF-κB binding activity, which is mediated through up-regulating the IκBα expression of PMs in AA rats.

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Effects and mechanisms of Clematis mandshurica Maxim. as a dual inhibitor of proinflammatory cytokines on adjuvant arthritis in rats

Cited by 13 publications

References 25 publications

Anti-arthritic activity of <i>Indigofera tinctoria</i> L on adjuvant induced arthritis

Anti-arthritic activity of <i>Indigofera tinctoria</i> L on adjuvant induced arthritis

Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators

Taurochenodeoxycholic Acid Suppresses NF-κB Activation and Related Cytokines Expression in Peritoneal Macrophages from Adjuvant Arthritis Rat

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