Effectivity of Black Tea Polyphenol in Adipogenesis Related IGF-1 and Its Receptor Pathway Through In Silico Based Study

Susanto, Hendra; Kharisma, Viol Dhea; Listyorini, Dwi; Taufiq, Ahmad; Sunaryono, Sunaryono; Aulanni’am, Aulanni’am

doi:10.1088/1742-6596/1093/1/012037

Cited by 19 publications

(20 citation statements)

References 45 publications

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“…TRs are one of the main substances that contribute to the red color and taste intensity of tea infusion. Importantly, TRs play a role similar to insulin or insulin-like growth factor in human cells and can become a new alternative for the treatment of overweight and obesity; it functions by activating lipolysis via mitochondrial uncoupling capacity and inactivating phosphoenolpyruvate carboxykinase (PEPCK) promoter as the major enzyme of gluconeogenesis through Forkhead box protein O1a (FOXO1a) phosphorylation ( 52 ). With the increasing oxidation degree of tea polyphenols, TRs and TFs are further oxidized and polymerized to TBs under the synergistic action of polyphenol oxidase (PPO), peroxidase (POD), and laccase produced by microorganisms, such as the genera Aspergillus , Pseudomonas , Eurotium , Debaryomyces , Lichtheimia , Blastobotrys , Rosellinia , Geotrichum , Lichtheimia , and Rasamsonia ( 9 ).…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Fungal Community, Chemical Composition, Antioxidant Activity, and Taste Characteristics of Fu Brick Tea in Different Regions of China

Chen

et al. 2022

Front. Nutr.

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In this study, the fungal community structure, metabolites, antioxidant ability, and taste characteristics of five Fu brick tea (FBT) from different regions of China were determined and compared. A total of 69 operational taxonomic units (OTUs) were identified and assigned into 5 phyla and 27 genera, with Eurotium as the predominant genus in all samples. Hunan (HN) sample had the strongest fungal diversity and richness, followed by Guangxi (GX) sample, and Zhejiang (ZJ) sample had the lowest. GX sample had higher amounts of gallic acid (GA), total catechins, gallocatechin (GC), and epicatechin gallate (ECG) as well as antioxidant activity than the other samples. The levels of total phenolics, total flavonoids, epigallocatechin (EGC), catechin, epicatechin (EC), thearubigins (TRs), and theaflavins (TFs) were the highest in the ZJ sample. Guizhou (GZ) and Shaanxi (SX) samples contained the highest contents of epigallocatechin gallate (EGCG) and gallocatechin gallate (GCG), respectively. Total phenolics, GA, EC, CG, and TFs were positively associated with most of fungal genera. Total phenolic content (TPC), total flavonoid content (TFC), and most of catechins contributed to the antioxidant activities of FBT. HN sample had the strongest sourness and sweetness, ZJ sample had the strongest saltiness, SX sample had the strongest umami, and GZ sample had the strongest astringency, which was ascribed to the varied metabolites. This work reveals that FBT in different regions vary greatly in fungal community, metabolites, antioxidant activity, and taste characteristics, and provides new insight into the quality characteristics formation of FBT in different regions.

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Section: Resultsmentioning

confidence: 99%

Comparison of the Fungal Community, Chemical Composition, Antioxidant Activity, and Taste Characteristics of Fu Brick Tea in Different Regions of China

Chen

et al. 2022

Front. Nutr.

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“…Meanwhile, the molecular docking study is a research model used for drug discovery to determine the binding interaction between ligand-protein [27,28]. This study was specific because the functional domain of the target protein was known.…”

Section: Resultsmentioning

confidence: 99%

Molecular Docking and Interaction Analysis of Propolis Compounds Against SARS-CoV-2 Receptor

Syaban

Faratisha²,

Yunita³

et al. 2022

J.Trop.Life.Science

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Background: For many people, especially in developing countries, herbal medicine is the most traditional drug choice to treat all diseases including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Propolis is one of the popular herbal medicine which has various health benefits, particularly antiviral activity. In this molecular docking study, this investigation examined twenty-five kinds of propolis to bind SARS-CoV-2 protein with the main targets of ACE-2 and M-Pro receptors. Method: Propolis ligands were downloaded from PubChem, meanwhile ACE-2 and M-Pro receptors were downloaded from Protein Data Bank. Both ligands and targets were optimized by Pymol. The pharmacokinetic analysis was conducted using SwissADME. Molecular docking was done using PyRx 0.9 and its binding interaction was visualized by Discovery Studio. To predict the potential inhibition, this study compared the ligand-protein complex of propolis to ligands from the previous study. Result: Through the Lipinski rule, only five of twenty-five types of propolis were not qualified for the criterion. The ability to bind protein targets were various between ligands, the highest affinity to ACE-2 receptors were abietic acid, galangin, chrysin, kaempferol and acacetin, respectively. The binding affinity between ligand and M-Pro were seen weaker than ACE-2 receptor, while the strongest were kaempferol, abietic acid, acacetin, galangin and chrysin, respectively. Conclusion: Â Kaempferol is the most potent form of propolis to bind to ACE-2 and M-Pro receptors by assessing the binding affinity and the amount of amino acid residue formation when compared to control ligands. Keywords: ACE-2 receptor, COVID-19, Main protease, Molecular docking, Propolis, SARS-CoV-2

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“…This research uses PyMol software for 3D visualization of molecular docking results. The 3D structure of the ligand-protein molecular complex is shown in the form of cartoons, surfaces, sticks, and spheres (Susanto et al, 2018).…”

Section: Molecular Visualizationmentioning

confidence: 99%

“…These interactions are played by hydrogen bonds, hydrophobicity, Van der Waals, and pi. Weak bonds are also possible to trigger the stability of the ligand-protein binding complex so that specific responses can run (Susanto et al, 2018;.…”

Section: Anthocyanin-foxp3mentioning

confidence: 99%

Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach

Ramadhani¹,

Nugraha²,

Rahmadhani³

et al. 2022

J Pharm Pharmacogn Res

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Context: Oral manifestations that arose from COVID-19 infection often causes morbidity and systemic drug administration is less effective. Roselle flower (Hibiscus sabdariffa) is one of the plants that is often used in infusion as it gives health benefits. Hence, H. sabdariffa may benefit from adjuvant therapy to treat oral manifestation due to COVID-19. Aims: To investigate the potential of H. sabdariffa anthocyanins, tartaric acid, and ascorbic acid chemical compounds as antiviral, anti-inflammatory, antioxidant, and increasing tissue regeneration in oral manifestation due to COVID-19 infection in silico. Methods: Chemical compounds consisted of anthocyanins, (+)-tartaric acid, and ascorbic acid beside target proteins consisted of ACE2-spike, Foxp3, IL-10, IL6, IL1β, VEGF, FGF-2, HSP70, TNFR and MDA-ovalbumin were obtained from the database, ligand samples were selected through absorption, distribution, metabolism, excretion and toxicology analysis, then molecular docking simulations, identification of protein-ligand interactions, and 3D visualization were performed. Results: Anthocyanins, tartaric acid, and ascorbic acid are the active compounds in H. sabdariffa, which act as antioxidants. The activity of anthocyanin compounds is higher than other compounds through value binding affinity, which is more negative and binds to specific domains of target proteins by forming weak binding interactions that play a role in biological responses. Anthocyanins have the most negative binding energy compared to tartaric-acid and ascorbic acid. Conclusions: Anthocyanins act as antioxidants; this mechanism increases heat shock protein-70 (HSP70), which may play an important role in increasing wound regeneration of oral manifestation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as documented in silico.

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Effectivity of Black Tea Polyphenol in Adipogenesis Related IGF-1 and Its Receptor Pathway Through In Silico Based Study

Cited by 19 publications

References 45 publications

Comparison of the Fungal Community, Chemical Composition, Antioxidant Activity, and Taste Characteristics of Fu Brick Tea in Different Regions of China

Comparison of the Fungal Community, Chemical Composition, Antioxidant Activity, and Taste Characteristics of Fu Brick Tea in Different Regions of China

Molecular Docking and Interaction Analysis of Propolis Compounds Against SARS-CoV-2 Receptor

Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach

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