Effectiveness of universal newborn hearing screening: A systematic review and meta-analysis

Edmond, Karen; Chadha, Shelly; Hunnicutt, Cynthia; Strobel, Natalie; Manchaiah, Vinaya; Yoshinga-Itano, Christine

doi:10.7189/jogh.12.12006

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…The middle-income countries represented included Bangladesh, China, Egypt, India, Iran, Pakistan, South Africa, Thailand, Tunisia and Turkey. The participant numbers varied across the included reviews, with sample sizes of the meta-analyses ranging from 58 participants with neuromotor delay [22] to 1,023,610 newborns evaluated for early screening for hearing loss [23].…”

Section: Resultsmentioning

confidence: 99%

“…The outcomes and impacts varied across the studies, ranging from reduction in core symptoms for ASD, improved cognitive function and adaptive behaviour, to neuroprotection and improved sitting balance. Table 2 provides a summary of studies focusing on various disabilities and their corresponding evidence for children under 5 years [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Data that were not disaggregated are presented in Additional file 3 .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review

Smythe,

Scherer,

Nanyunja

et al. 2024

BMC Med

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Background There are over 53million children worldwide under five with developmental disabilities who require effective interventions to support their health and well-being. However, challenges in delivering interventions persist due to various barriers, particularly in low-income and middle-income countries. Methods We conducted a global systematic umbrella review to assess the evidence on prevention, early detection and rehabilitation interventions for child functioning outcomes related to developmental disabilities in children under 5 years. We focused on prevalent disabilities worldwide and identified evidence-based interventions. We searched Medline, Embase, PsychINFO, and Cochrane Library for relevant literature from 1st January 2013 to 14th April 2023. A narrative synthesis approach was used to summarise the findings of the included meta-analyses. The results were presented descriptively, including study characteristics, interventions assessed, and outcomes reported. Further, as part of a secondary analysis, we presented the global prevalence of each disability in 2019 from the Global Burden of Disease study, identified the regions with the highest burden and the top ten affected countries. This study is registered with PROSPERO, number CRD42023420099. Results We included 18 reviews from 883 citations, which included 1,273,444 children under five with or at risk of developmental disabilities from 251 studies across 30 countries. The conditions with adequate data were cerebral palsy, hearing loss, cognitive impairment, autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder. ASD was the most prevalent target disability (n = 8 reviews, 44%). Most reviews (n = 12, 67%) evaluated early interventions to support behavioural functioning and motor impairment. Only 33% (n = 10/30) of studies in the reviews were from middle-income countries, with no studies from low-income countries. Regarding quality, half of reviews were scored as high confidence (n = 9/18, 50%), seven as moderate (39%) and two (11%) as low. Conclusions We identified geographical and disability-related inequities. There is a lack of evidence from outside high-income settings. The study underscores gaps in evidence concerning prevention, identification and intervention, revealing a stark mismatch between the available evidence base and the regions experiencing the highest prevalence rates of developmental disabilities.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review

Smythe,

Scherer,

Nanyunja

et al. 2024

BMC Med

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“…The participant numbers varied across the included reviews, with sample sizes of the meta-analyses ranging from 58 participants with neuromotor delay 23 to 1,023,610 newborns evaluated for early screening for hearing loss. 24 Regarding quality review, this umbrella review includes a majority of reviews (n = 16, 89%) with high and moderate con dence (nine reviews and seven reviews respectively) and two reviews (11%) of low con dence (Web appendix 2 show the results of the risk of bias assessment of each study with the AMSTAR tool, including the studies that were not disaggregated by age). The most common reasons for low con dence included a combination of the absence of an explicit statement regarding the establishment of review methods before conducting the review, the lack of a list detailing excluded studies and justifying these exclusions, and inadequate investigation of publication bias.…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis of reviews on prevention for CP highlights the e cacy of interventions such as antenatal corticosteroids, 27 magnesium sulfate, 27 prophylactic caffeine, 28 and neonatal therapeutic hypothermia 28 24 Regarding ADHD, neurocognitive and behavioural interventions may reduce ADHD symptoms and positively in uence working memory. 38 The ndings suggest that diagnostic tools for ASD can be useful in early detection, but each test may have varying levels of sensitivity and speci city.…”

Section: Discussionmentioning

confidence: 99%

Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review

Smythe,

Scherer,

Nanyunja

et al. 2023

Preprint

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Background: There are over 53million children worldwide under five with developmental disabilities, necessitating effective interventions to alleviate the impact of these conditions. However, challenges in delivering interventions persist due to various barriers, particularly in low-income and middle-income countries. Methods: We conducted a global systematic umbrella review to assess the evidence on early detection, prevention, and rehabilitation interventions for child functioning outcomes related to developmental disabilities in children under five years. We focused on prevalent disabilities worldwide and identified evidence-based interventions at the primary, secondary, and tertiary levels. We searched Medline, Embase, PsychINFO, and Cochrane Library for relevant literature from 1st January 2013 to 14th April 2023. A narrative synthesis approach was used to summarise the findings of the included meta-analyses. The results were presented descriptively, including study characteristics, interventions assessed, and outcomes reported. Further, we presented the global prevalence of each disability in 2019 from the Global Burden of Disease study, identified the regions with the highest burden and the top ten affected countries. This study is registered with PROSPERO, number CRD42023420099. Results: We included 18 reviews from 883 citations, which included 1,273,444 children under five with or at risk of developmental disabilities from 251 studies across 30 countries. The conditions with adequate data were cerebral palsy, hearing loss, cognitive impairment, autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder. ASD was the most prevalent target disability (n=8 reviews, 44%). Most reviews (n=12, 67%) evaluated early interventions to support behavioural functioning and motor impairment. Only 33% (n=10/30) of studies in the reviews were from middle-income countries, with no studies from low-income countries. Regarding quality, half of reviews were scored as high confidence (n=9/18, 50%), seven as moderate (39%), and two (11%) as low. Conclusion: We identified geographical and disability-related inequities. There is a lack of evidence from outside high income settings. The study underscores gaps in evidence concerning prevention, identification, and intervention, revealing a stark mismatch between the available evidence base and the regions experiencing the highest prevalence rates.

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“…Hearing assessment should also form part of follow-up, 125 as prompt identification of hearing impairment and intervention (assistive devices, speech therapy) may improve outcomes. 126 Hearing impairment may also result from ototoxic antibiotic use, particularly where routine monitoring may not be possible. 127 …”

Section: Follow-upmentioning

confidence: 99%

Improving the Treatment of Neonatal Sepsis in Resource-Limited Settings: Gaps and Recommendations

Sturrock,

Sadoo,

Nanyunja

et al. 2023

RRTM

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Neonatal sepsis causes significant global morbidity and mortality, with the highest burden in resource-limited settings where 99% of neonatal deaths occur. There are multiple challenges to achieving successful treatment of neonates in this setting. Firstly, reliable and low-cost strategies for risk identification are urgently needed to facilitate treatment as early as possible. Improved laboratory capacity to allow identification of causative organisms would support antimicrobial stewardship. Antibiotic treatment is still hampered by availability, but also increasingly by antimicrobial resistance – making surveillance of organisms and judicious antibiotic use a priority. Finally, supportive care is key in the management of the neonate with sepsis and has been underrecognized as a priority in resource-limited settings. This includes fluid balance and nutritional support in the acute phase, and follow-up care in order to mitigate complications and optimise long-term outcomes. There is much more work to be done in identifying the holistic needs of neonates and their families to provide effective family-integrated interventions and complete the package of neonatal sepsis management in resource-limited settings.

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Effectiveness of universal newborn hearing screening: A systematic review and meta-analysis

Cited by 13 publications

References 35 publications

Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review

Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review

Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review

Improving the Treatment of Neonatal Sepsis in Resource-Limited Settings: Gaps and Recommendations

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