Effectiveness of the anxiolytic Anvifen in the treatment of post-COVID brain fog

Esin, R. G.; Хайруллин, И. Х.; Esin, O R; Malova, L A; Alimbekova, L.R.

doi:10.17116/jnevro2022122081101

Cited by 3 publications

(15 citation statements)

References 19 publications

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“…Table 2 provides an overview of included studies. Of all included studies, one study was retained based on a relevant abstract in the absence of a full text despite multiple attempts to obtain it [ 50 ]. All studies were written in the English language except for three, written in Russian [ 50 – 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of all included studies, one study was retained based on a relevant abstract in the absence of a full text despite multiple attempts to obtain it [ 50 ]. All studies were written in the English language except for three, written in Russian [ 50 – 52 ]. The included studies were conducted in nine countries, with more than half conducted in Europe ( n = 11, 64.7%), five of which were from the UK.…”

Section: Resultsmentioning

confidence: 99%

“…Compagno et al, 2022 [ 57 ], Italy Single arm pre-post design Hospital out-patient care NR N = 30 Gender : 12 women, 18 men Age : mean 58 years Ethnicity : NR A mean of 3 (range 1–6) months since resolution of acute COVID-19 infection 8. Esin et al, 2022 [ 50 ], Russia Three arm clinical trial with pre-post assessment Home or hospital setting NR N = 92 Gender : NR Age : Group 1 ( n = 40) mean 43 years Group 2 ( n = 32) mean 45 years Group 3 (n = 20) mean 45 years Ethnicity : NR Had acute COVID-19 infection 12 weeks earlier 9. Brough et al, 2022 [ 58 ], UK Service evaluation with pre-post assessment Community setting Self-referral, advertised through social media, social prescribing network and word of mouth N = 25 Gender : 15 women, 7 men, 3 gender not disclosed Age : range 15–92 years Ethnicity : white British ( n = 18), white Asian ( n = 1), other white background ( n = 2), Chinese ( n = 1), undisclosed ( n = 3) NR 10.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 17 included studies, six were case studies [ 53 , 56 , 59 , 62 – 64 ] and five were clinical trials [ 50 – 52 , 60 , 61 ], two of the latter were randomised controlled trials (RCTs) [ 60 , 61 ]. Other designs encompassed four single arm pre-post studies [ 55 , 57 , 65 , 66 ], one qualitative study [ 54 ] and a single service evaluation study [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies did not report the method used in recruiting participants [ 50 – 52 , 56 , 57 , 59 , 63 , 64 ]. Described recruitment approaches included social media, referral from LC clinics, medical doctors, or a local community network.…”

Section: Resultsmentioning

confidence: 99%

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Interventions to support mental health in people with long COVID: a scoping review

et al. 2023

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Introduction Long COVID (LC) is a multisystem disease with symptoms lasting weeks or months beyond the acute COVID-19 infection. Several manifestations are reported by people with LC, including effects on mental health, with varying degrees of psychological distress and disturbances to daily activities. Research conducted to identify effective interventions to support mental health among people with LC has been limited by the breadth and scope of studies. Aim This review aims to identify interventions being tested to support mental health of people with LC. Methods A scoping review was conducted by searching five databases for articles published between January 2020 and early October 2022 to identify research evaluating interventions focused on improving mental health symptoms associated with LC. Results from all sources were checked for eligibility by two reviewers, and agreements were resolved by discussion. Gray literature and reference list of included studies and relevant reviews were scrutinised to identify any additional studies. Data extraction was conducted by one reviewer and checked by another reviewer for accuracy. Results Of the 940 studies identified, 17 were included, the design of which varied but included mainly case studies (n = 6) and clinical trials (n = 5). Several interventions were described, ranging from single interventions (e.g., pharmacologic) to more holistic, comprehensive suites of services (pharmacologic and non-pharmacologic). Several mental health outcomes were measured, mostly anxiety and depression. All included studies were reported to be associated with improvements in participants’ mental health outcomes. Conclusion This scoping review identified studies reporting on a variety of interventions to support mental health among people with LC. Although positive changes were reported by all studies, some were case studies and thus their findings must be interpreted with caution. There is a need for more research to be conducted to identify the impact of interventions on mental health of people with LC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Interventions to support mental health in people with long COVID: a scoping review

et al. 2023

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The effectiveness of short and prolonged course treatment of anxiety with Anvifen

Esin¹,

Хайруллин²,

Esin³

et al. 2022

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Insomnia and anxiety in older adults

Пизова

Пизов

2023

Medicinskij sovet

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A share of older persons among the general population has been increasing. Mental health is the most important determinant of health status of older people. Anxiety in later life is the most common mental disease. Various diseases and symptoms often occur at the advanced age. In older adults, anxiety disorders are associated with an increased risk of comorbidities. Although insomnia is not a normal part of the ageing process, its prevalence increases with age. Many older people experience dissatisfaction with the quantity and quality of sleep, even if they get enough sleep. Ageing is associated with some changes in parameters of sleep architecture and continuity. There are several demographic, psychosocial, biological, and behavioural factors that may contribute to insomnia later in life. Older people are subject to greater risk for the physical and mental consequences of insomnia. Patients with long-term insomnia usually experience anxiety and depression. Evidence suggests that there is a complex bidirectional relationship between insomnia and anxiety in the elderly. Sleep disturbances are part of the anxiety disorder pattern. Therefore, healthcare workers must obtain comprehensive information about the health and sleep status of older people to correctly diagnose insomnia, anxiety, and identify potential correlates of these disorders. Taking a careful and complete medical history and performing a thorough physical examination is the most important aspect of their evaluation. If insomnia and anxiety are diagnosed in later life, therapy should include non-drug and drug treatments, taking into account possible side effects.

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Effectiveness of the anxiolytic Anvifen in the treatment of post-COVID brain fog

Cited by 3 publications

References 19 publications

Interventions to support mental health in people with long COVID: a scoping review

Interventions to support mental health in people with long COVID: a scoping review

The effectiveness of short and prolonged course treatment of anxiety with Anvifen

Insomnia and anxiety in older adults

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