Effectiveness of selenium supplements in a low-selenium area of China

Xia, Yiming; Hill, Kristina E.; Byrne, Daniel W.; Xu, Jiayuan; Burk, Raymond F.

doi:10.1093/ajcn/81.4.829

Cited by 312 publications

(200 citation statements)

References 13 publications

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“…Since it has been recently shown that the two serum selenoproteins (Sel P and GPX 3) are maximally expressed at different levels of supplemental selenium [19], we wanted to determine if two selenoproteins were induced to the same extent at the same level of selenium supplementation in prostate cells. To that end, the samples used to examine GPX1 levels were also examined for GPX4 expression via Selenoproteins in prostate cells 944 npg mentation increased GPX2 levels only by about a factor of ~2.…”

Section: Gpx4 Induction Is Similar To That Of Gpx1mentioning

confidence: 99%

Selenoprotein expression is regulated at multiple levels in prostate cells

2006

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Selenium supplementation in a population with low basal blood selenium levels has been reported to decrease the incidence of several cancers including prostate cancer. Based on the clinical findings, it is likely that the antioxidant function of one or more selenoproteins is responsible for the chemopreventive effect, although low molecular weight seleno-compounds have also been posited to selectively induce apoptosis in transformed cells. To address the effects of selenium supplementation on selenoprotein expression in prostate cells, we have undertaken an analysis of antioxidant selenoprotein expression as well as selenium toxicity in non-tumorigenic prostate epithelial cells (RWPE-1) and prostate cancer cells (LNCaP and PC-3). Our results show that two of the glutathione peroxidase family members (GPX1 and GPX4) are highly induced by supplemental selenium in prostate cancer cells but only slightly induced in RWPE-1 cells. In addition, GPX1 levels are dramatically lower in PC-3 cells as compared to RWPE-1 or LNCaP cells. GPX2 protein and mRNA, however, are only detectable in RWPE-1 cells. Of the three selenium compounds tested (sodium selenite, sodium selenate and selenomethionine), only sodium selenite shows toxicity in a physiological range of selenium concentrations. Notably and in contrast to previous studies, RWPE-1 cells were significantly more sensitive to selenite than either of the prostate cancer cell lines. These results demonstrate that selenoproteins and selenium metabolism are regulated at multiple levels in prostate cells.Cell Research (2006) 16:940-948.

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Section: Gpx4 Induction Is Similar To That Of Gpx1mentioning

confidence: 99%

Selenoprotein expression is regulated at multiple levels in prostate cells

2006

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“…Se has been studied in relation to this neoplasia due to its possible preventive effects on DNA damage. The chemical form of Se and the dose are determinants of its biological activities as an essential nutrient, chemopreventive agent, or toxicant (33,(35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Plasma Selenium Measurements in Subjects from Areas with Contrasting Gastric Cancer Risks in Colombia

Camargo

Burk

Bravo

et al. 2008

Archives of Medical Research

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“…The normative individual and population requirements for Se are based on the results from the United States, and are 27 and 39 mg/day, respectively (WHO, 1996). It has also been suggested that selenoprotein P is a better indicator of selenium nutritional status than glutathione peroxidase, and thus the recommended dietary allowance of selenium may need to be greater than that of World Health Organization, because full expression of selenoprotein P requires a greater selenium intake than does full expression of plasma glutathione peroxidase (Xia et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Selenium levels of Estonians

et al. 2007

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Background: The objective of this study is to sum up the dietary selenium intake of the Estonian people according to the serum selenium concentrations. Subjects/methods: This research compiles the information published in the literature about the levels of selenium in the serum of the Estonian people. We compare these results with the findings obtained from the analyses of serum samples gathered by us in the 1990s in Estonia.Results: The selenium concentration in sera of 404 Estonians ranged from 26 to 116 mg/l; the mean was 75 mg/l. The selenium contents of Estonians were at a similar level as reported for Finns before the selenium supplementation of fertilizers carried out in Finland in 1984. Conclusion: In view of the selenium concentration in the sera, we suggest that the dietary selenium intake among the Estonian people might be scarce, and Estonian authorities should consider in their nutrition policies the possible low intake of selenium of Estonians.

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Effectiveness of selenium supplements in a low-selenium area of China

Cited by 312 publications

References 13 publications

Selenoprotein expression is regulated at multiple levels in prostate cells

Selenoprotein expression is regulated at multiple levels in prostate cells

Plasma Selenium Measurements in Subjects from Areas with Contrasting Gastric Cancer Risks in Colombia

Selenium levels of Estonians

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