Numerical simulations have been widely used to study the inelastic response of reinforced concrete structures
under earthquake loading. Yet, due to the complex nature of structural inelastic behavior, experimental results are often
required to verify the efficiency of applied numerical schemes. In this paper, experimental results of bare reinforced concrete
frame models are employed to validate numerical calculations using the code Seismostruct. Moreover, numerical
simulations investigate the influential parameters related to the physical experiment configuration and numerical analysis
options and determine their effect on the obtained structural response. The experimental setup concerns a well-defined
case study of a reinforced concrete frame under cyclic horizontal loading. The fixed base frame is subjected to increasing
horizontal forces, leading to the development of plastic hinges at the structural elements. The adopted numerical approach
describes successfully the inelastic behavior of the frame, as indicated by the obtained results of the overall structural response
as well as the plastic hinge formation at cross section level. Comparison of the plastic hinge formation mechanism
in particular, raises interesting remarks on the conditions and constraints of the physical experiments and highlights the
valuable contribution of numerical simulations in their design.