Effectiveness of Probiotics, Metformin and Their Combination Therapy in Ameliorating Dyslipidemia Associated With PCOS

Zafar, Urooj; Hassan, Jahan Ara; Ismail, Kauser; Agha, Shanza; Memon, Zahida; Bhatty, Shaheen

doi:10.9734/jpri/2019/v30i430275

Cited by 4 publications

(2 citation statements)

References 32 publications

(32 reference statements)

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“…It is also well known that elevated androgen levels disrupt the menstrual cycle in women who do not have clinical hyperandrogenism. The dysregulation of hormone in the hypothalamic-pituitary-gonadal (HPG) axis, results in raised androgens and estrogens levels; hypersecretion of luteinizing hormone (LH); and decreased follicle stimulating hormone (FSH) synthesis in females eventually causing menstrual abnormalities [12,13].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Age-Related Association of Abnormal Endocrine Changes among Women with Menstrual Disorder

Mughal

Kumar

Maheshwari

et al. 2021

JPRI

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Background: The menstrual cycle describes the healthy reproductive system of the women which is controlled by different hormones. Aim: The goal of the study is to evaluate the prevalence of irregular menstruation in different endocrine changes and to identify their association with the age of women in reproductive life. Methodology: It was a cross-sectional study conducted on women attending the gynecological clinic of Karachi from March 2019 to June 2019. Of the 165 women with different hormonal changes 100 presented with menstrual cycle abnormality. Results: Among the women with menstrual irregularities 51% women presented with insulin resistance, 23% with hyperandrogenism, 19% with hypothyroidism and 7% hyperprolactinemia. Age-related association was observed in menstrual irregularities women with insulin resistant and hyperandrogenism. Conclusion: Menstrual cycle is a physiological process, any irregularities in cycle can be caused by even minimal hormonal imbalance. As a result, it is critical to address endocrine abnormalities in order to improve women's reproductive health.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Age-Related Association of Abnormal Endocrine Changes among Women with Menstrual Disorder

Mughal

Kumar

Maheshwari

et al. 2021

JPRI

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“…PCOS is not merely a reproductive disorder but an endocrinological disorder affecting women in their reproductive years. It is defined by the Rotterdam criteria as a combination of oligo / amenorrhea, clinical or endocrine signs of hyperandrogenism, and polycystic ovaries on ultrasonography [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Metformin and its Combination with Probiotic in Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial

Zafar¹,

Zaidi²,

Jafri³

et al. 2021

JPRI

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Background: Polycystic ovarian syndrome (PCOS) is an endocrine disorder that predominantly affects women of the reproductive age. Anovulation and abnormal uterine bleeding are caused by hyperprolactinemia, which affects the hypothalamic-pituitary-ovarian axis. Aim: In this study, the efficacy of combined Probiotic and Metformin therapy on hyperprolactinemia levels in PCOS patients was compared to Metformin therapy alone. Methodology: 102 participants having hyperprolactinemia were enrolled via convenient sampling technique between January 2019 to August 2019. Out of them women having Polycystic Ovarian Syndrome (PCOS) and high serum prolactin levels were randomly assigned to one of two groups: group one received oral Metformin tablet 500 mg T.D. for three months, and group two received oral Metformin tablet 500 mg T.D and Probiotic capsule 180 mg O.D for three months. Serum prolactin levels in both groups were compared before and after treatment. Results: 54 (53%) of the 102 hyperprolactinemia women had PCOS. The Combination group showed improvement in reduction in hyperprolactinemia levels after 12 weeks of intervention. Conclusion: The addition of Probiotic to Metformin improved prolactin levels in women with polycystic ovarian syndrome with hyperprolactinemia more than Metformin alone.

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Metformin Combined LMWH Intervention in 25 Pregnant Women with History of Hyperlipidemia Pancreatitis in Pregnancy

Peng

Deng

et al. 2021

Glob Clin Transl Res

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Objective: To explore the early preventive treatment of hypertriglyceridemia-induced acute pancreatitis (HTGP) in pregnancy. Methods: A retrospective cohort analysis was performed to examine the drug intervention on recurrent HTGP and related pregnancy outcomes among women who had HTGP in their past pregnancy and developed hyperlipidemia during the second pregnancy. Participants were identified through inpatient case records under a single physician at the clinic and divided into two groups. The intervention group was given metformin lipid-lowering combined with low-molecular-weight heparin to prevent thrombosis when hypertriglyceridemia was developed during the pregnancy. In contrast, the non-intervention group includes those who did not receive active drug treatment until they developed recurrent HTGP. Metabolic markers were also examined by comparing them with their respective past pregnancies. Results: All participants experienced elevated triglycerides during their two consecutive pregnancies. No pregnant women developed HTGP in the intervention group (n=12), while 10 of 13 (76.9%) women developed HTGP in the non-intervention group. Thus, the outcome seemed to be markedly different. In the intervention group, 11 women were gestated to term, and one was premature; one of 12 (8.3%) births was neonatal asphyxia; there was no low-weight birth, and the prognosis of mother and baby was favorable. Of 10 women who developed recurrent HTGP in the non-intervention group, four suffered from fetal loss, four had premature, and two had full-term delivery; among the three pregnant women without HTGP, one had a premature and two had full-term births; five of thirteen (38.5%) births were neonatal asphyxia. Conclusion: Pregnant women with HTGP history, if not treated, are likely to develop the condition recurrently during pregnancy, but timely intervention on hypertriglyceridemia with lipid-lowering and thrombosis-preventing seemed complete to reduce the recurrent HTGP and improve the pregnancy outcomes.

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Effectiveness of Probiotics, Metformin and Their Combination Therapy in Ameliorating Dyslipidemia Associated With PCOS

Cited by 4 publications

References 32 publications

Prevalence and Age-Related Association of Abnormal Endocrine Changes among Women with Menstrual Disorder

Prevalence and Age-Related Association of Abnormal Endocrine Changes among Women with Menstrual Disorder

Effectiveness of Metformin and its Combination with Probiotic in Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial

Metformin Combined LMWH Intervention in 25 Pregnant Women with History of Hyperlipidemia Pancreatitis in Pregnancy

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