DOI: 10.1155/2013/903172
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Abbas Aghabiklooei, Hossein Hassanian-Moghaddam, Nasim Zamani, Shahin Shadnia, Mohammad Mashayekhian, Mitra Rahimi, Soheil Nasouhi, Ahmad Ghoochani

Abstract: Acute methadone toxicity is a major public health concern in Iran. Methadone-intoxicated patients are in a great risk of recurrent or delayed respiratory arrest despite the prescription of initial doses of naloxone. This study aimed to evaluate the effectiveness of oral naltrexone in the management of acute methadone overdose in opioid-naive patients and check if it could be a substitute of continuous infusion of naloxone in maintaining adequate ventilation. In a randomized, double-blind, placebo-controlled st…

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