Effectiveness of misoprostol for office hysteroscopy without anesthesia in infertile patients

Sordia-Hernández, Luis H.; Rosales-Tristan, Elizabeth; Vazquez-Mendez, Juanita; Merino, M.; Iglesias, J.; Garza-Leal, J.; Morales, Arturo

doi:10.1016/j.fertnstert.2010.07.1066

Cited by 37 publications

(30 citation statements)

References 23 publications

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“…In agreement with our results, Sordia-Hern andez et al (17) reported that vaginal misoprostol at a dose of 200 mg inserted 12 hours apart, starting 24 hours before OH without anesthesia for investigation of infertility, considerably reduces pain and the time needed for hysteroscopy compared with oral misoprostol administration and placebo. They reported only one patient with nausea and two patients with referred abdominal pain in the vaginal misoprostol group (n ¼ 20).…”

Section: Discussionsupporting

confidence: 93%

A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy

El-Mazny

Abou-Salem

2011

Fertility and Sterility

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Section: Discussionsupporting

confidence: 93%

A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy

El-Mazny

Abou-Salem

2011

Fertility and Sterility

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“…Other randomized controlled studies which included nulliparous patients or patients of reproductive age in their study population have contradictory results [21][22][23][24]. A randomized controlled trial evaluating the efficacy of vaginal misoprostol and oral misoprostol in minimizing the pain perceived by nulliparous women during office hysteroscopy revealed that vaginal misoprostol significantly reduced the procedure related pain and oral misoprostol was not effective in reducing the procedure related pain [21].…”

Section: Misoprostol Prior To Office Hysteroscopymentioning

confidence: 99%

“…A randomized controlled trial evaluating the efficacy of vaginal misoprostol and oral misoprostol in minimizing the pain perceived by nulliparous women during office hysteroscopy revealed that vaginal misoprostol significantly reduced the procedure related pain and oral misoprostol was not effective in reducing the procedure related pain [21]. On the contrary, Hassa et al [22] found that vaginal misoprostol (200 µg given 6 h before office hysteroscopy) and diclofenac sodium (100 mg administered rectally 1 h before office hysteroscopy) were not effective in minimizing the pain perceived by nulliparous women during office hysteroscopy.…”

Section: Misoprostol Prior To Office Hysteroscopymentioning

confidence: 99%

Misoprostol Prior to Diagnostic Office Hysteroscopy in the Subgroup of Patients with No Risk Factors for Cervical Stenosis: A Randomized Double Blind Placebo-Controlled Trial

Fouda

Elsetohy

Elshaer

et al. 2017

Gynecol Obstet Invest

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Aims: To assess the effectiveness of vaginal misoprostol in minimizing the pain perceived by patients with no risk factors for cervical stenosis (i.e., parous women of reproductive age who have no history of cesarean section or cervical surgery) during diagnostic office hysteroscopy. Methods: A total of 100 patients with no risk factors for cervical stenosis were randomized to the misoprostol group (n = 50) or the placebo group (n = 50). In the misoprostol group, 2 misoprostol tablets (400 µg) were administered vaginally 12 h before office hysteroscopy. In the placebo group, 2 placebo tablets were administered. The patients rated the intensity of pain perceived during the procedure and at 30 min after the procedure with the use of a 100 mm visual analog scale (VAS). The hysteroscopists also scored the difficulty of hysteroscope insertion into the uterine cavity with the use of a 100 mm VAS. Results: There were no significant differences between both groups in the VAS pain scores during or at 30 min after the procedure (28.3 ± 13.58 vs. 30.42 ± 15.13 and 11.1 ± 10.23 vs. 13.32 ± 11.12, respectively). The difficulty of hysteroscope insertion into the uterine cavity was comparable between both groups. Conclusion: Misoprostol administration prior to diagnostic office hysteroscopy appears to have no beneficial role in the subgroup of patients with no risk factors for cervical stenosis.

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“…The cervical ripening effect of misoprostol by different routes of administration has been demonstrated in labor, abortion induction and hysteroscopy [12,13,14]. Only a few studies have evaluated the use of misoprostol administered via different routes for women undergoing dilation and curettage.…”

Section: Introductionmentioning

confidence: 99%

Vaginal Misoprostol versus a Rectal Nonsteroidal Anti-Inflammatory Drug to Reduce Pain during Pipelle Endometrial Biopsies: A Prospective, Randomized, Placebo-Controlled Trial

Telli

Aydın²,

Öge

et al. 2014

Gynecol Obstet Invest

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Background: To evaluate and compare the efficacy of vaginal misoprostol and a rectal nonsteroidal anti-inflammatory drug (NSAID) on pain relief during Pipelle endometrial biopsies in a placebo-controlled randomized study. Methods: One hundred and fifty-one women who had an indication for a Pipelle endometrial biopsy were randomized into three groups as follows: group 1, vaginal misoprostol; group 2, rectal NSAID, and group 3, control. After the procedure, the women were asked to record their pain severity on a visual analog scale. The secondary outcome of the study was patient acceptability, and vasovagal symptoms and analgesic requirements after the procedure were also recorded. Results: There were no statistically significant differences in the demographic characteristics of the patients. The primary study outcome was the comparison of the median visual analog scale pain scores of groups 1 and 2 versus group 3 (controls); no statistically significant differences were found (p = 0.502). In addition, the patient acceptability (Likert scale), vasovagal symptoms and analgesic requirements after the procedure were similar among the groups (p = 0.204, 1 and 0.546, respectively). Conclusion: Our study did not demonstrate a reduction in pain relief during Pipelle endometrial biopsies for patients receiving vaginal misoprostol or a rectal NSAID when compared to patients receiving placebo treatment.

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Effectiveness of misoprostol for office hysteroscopy without anesthesia in infertile patients

Cited by 37 publications

References 23 publications

A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy

A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy

Misoprostol Prior to Diagnostic Office Hysteroscopy in the Subgroup of Patients with No Risk Factors for Cervical Stenosis: A Randomized Double Blind Placebo-Controlled Trial

Vaginal Misoprostol versus a Rectal Nonsteroidal Anti-Inflammatory Drug to Reduce Pain during Pipelle Endometrial Biopsies: A Prospective, Randomized, Placebo-Controlled Trial

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